Results 51 to 60 of about 446,328 (302)

TGFbeta induces apoptosis and EMT in primary mouse hepatocytes independently of p53, p21(Cip1) or Rb status [PDF]

, 2008
Melville Trust for the Care and Cure of Cancer to SP and SS.Background: TGF beta has pleiotropic effects that range from regulation of proliferation and apoptosis to morphological changes and epithelial-mesenchymal transition (EMT).
Sharon Sheahan, Harrison David J, Harland, Stephen N., David J Harrison, Prost Sandrine, Sandrine Prost, Stephen N Hartland, Bellamy, Christopher O., Harland Stephen N, Christopher O Bellamy, Sheahan Sharon, Sheahan, Sharon, Bellamy Christopher O, Prost, Sandrine, Harrison, David J.   +14 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death [PDF]

, 2005
In large models of neuronal cell death, there is a tight correlation between Cdk5 deregulation and cell-cycle dysfunction. However, pathways that link Cdk5 to the cell cycle during neuronal death are still unclear.
Sambo, Anne-Véronique, Philippe Bertrand, Bégard, Séverine, Luc Buée, André Delacourte, Séverine Bégard, Bertrand, Philippe, Hamdane, Malika, Katharina Schindowski, Bretteville, Alexis, Anne-Véronique Sambo, Schindowski, Katharina, Delacourte, André, Buée, Luc, Malika Hamdane, Alexis Bretteville   +15 more
core   +1 more source

Apoptosis-induced release of mature sterol regulatory element-binding proteins activates sterol-responsive genes

Journal of Lipid Research, 2001
It is well established that during the execution of the apoptotic cascade, activated caspase 3 releases sterol regulatory element-binding proteins (SREBP) from the membrane of the endoplasmic reticulum in a proteolytic reaction that is distinct from ...
Maureen E. Higgins, Yiannis A. Ioannou
doaj   +1 more source

Diverse maturity-dependent and complementary anti-apoptotic brakes safeguard human iPSC-derived neurons from cell death

Cell Death and Disease, 2022
In humans, most neurons are born during embryonic development and have to persist throughout the entire lifespan of an individual. Thus, human neurons have to develop elaborate survival strategies to protect against accidental cell death.
Ruven Wilkens, Anne Hoffrichter, Karolina Kleinsimlinghaus, Bettina Bohl, Carolin Haag, Nadja Lehmann, Malin Schmidt, Elena Muñoz Perez-Vico, Julia Wangemann, Klara Franziska Rehder, Sandra Horschitz, Georg Köhr, Julia Ladewig, Philipp Koch   +13 more
doaj   +1 more source

Cell Cycle and Apoptosis Regulatory Protein (CARP)-1 is Expressed inOsteoblasts and Regulated by PTH [PDF]

Biochemical and Biophysical Research Communications, 2013
Bone mass is dependent on osteoblast proliferation, differentiation and life-span of osteoblasts. Parathyroid hormone (PTH) controls osteoblast cell cycle regulatory proteins and suppresses mature osteoblasts apoptosis. Intermittent administration of PTH increases bone mass but the mechanism of action are complex and incompletely understood. Cell Cycle
Sonali, Sharma, Chandrika D, Mahalingam, Varsha, Das, Shazia, Jamal, Edi, Levi, Arun K, Rishi, Nabanita S, Datta   +6 more
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Effects of antipsychotics, haloperidol and olanzapine, on the expression of apoptosis-related genes in mouse mHippoE-2 cells and rat hippocampus

Endocrine Regulations, 2023
Objective. Modified levels of pro- (caspase3, Bax) and anti-apoptotic (Bcl-2) regulatory proteins have been detected in certain brain areas of schizophrenic patients indicating a possible dysregulation of apoptosis.
Osacka Jana, Kiss Alexander, Bacova Zuzana, Tillinger Andrej   +3 more
doaj   +1 more source

ASPP2 Coordinates ERS-Mediated Autophagy and Apoptosis Through mTORC1 Pathway in Hepatocyte Injury Induced by TNF-α

Frontiers in Pharmacology, 2022
Background: Though ASPP2 plays an important role in regulating cell apoptosis and autophagy in case of liver injury, there remains a lack of clarity on the molecular mechanism of ASPP2 regulating autophagy and apoptosis.Methods: A hepatocyte injury model
Jia Yao, Hui Yang, Hui Yang, Han Wang, Honglin Shi, Honglin Shi, Yan Jiao, Yan Jiao, Ying Zhang, Ying Zhang, Dexi Chen, Dexi Chen, Hongbo Shi, Hongbo Shi   +13 more
doaj   +1 more source

BTat, a trans-acting regulatory protein, contributes to bovine immunodeficiency virus-induced apoptosis [PDF]

Cellular Microbiology, 2007
Bovine immunodeficiency virus (BIV) is a member of the lentivirus subfamily of retroviruses highly related to human immunodeficiency virus in morphologic, antigenic and genomic features. BIV is known to induce chronic pathological changes in infected hosts, which are often associated with the development of immune-mediated lesions.
Chenghao, Xuan, Wentao, Qiao, Jian, Li, Guoyuan, Peng, Min, Liu, Qimin, Chen, Jun, Zhou, Yunqi, Geng   +7 more
openaire   +2 more sources