Results 51 to 60 of about 3,365,976 (292)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

GAS5 Long Noncoding RNA Regulates CD20 Expression and Rituximab Response [PDF]

Advanced Pharmaceutical Bulletin
Purpose: Rituximab is the primary treatment for non-Hodgkin lymphoma (NHL), one of the most common cancers globally. One of the main challenges associated with rituximab therapy is the decline in its effectiveness over time.
Mahbubeh Rojhannezhad, Zahra Abedi Kichi, Abbas Nikravesh, Mehrdad Behmanesh   +3 more
doaj   +1 more source

Cell Cycle and Apoptosis Regulatory Protein (CARP)-1 is Expressed inOsteoblasts and Regulated by PTH [PDF]

Biochemical and Biophysical Research Communications, 2013
Bone mass is dependent on osteoblast proliferation, differentiation and life-span of osteoblasts. Parathyroid hormone (PTH) controls osteoblast cell cycle regulatory proteins and suppresses mature osteoblasts apoptosis. Intermittent administration of PTH increases bone mass but the mechanism of action are complex and incompletely understood. Cell Cycle
Sonali, Sharma, Chandrika D, Mahalingam, Varsha, Das, Shazia, Jamal, Edi, Levi, Arun K, Rishi, Nabanita S, Datta   +6 more
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Mcl-1 is a key regulator of apoptosis resistance in Chlamydia trachomatis-infected cells [PDF]

, 2008
Chlamydia are obligate intracellular bacteria that cause variety of human diseases. Host cells infected with Chlamydia are protected against many different apoptotic stimuli.
Manu Sharma, Christopher J Froelich, Oswald Monique, Sharma Manu, Lohmann, C., Oswald, M., Christine Lohmann, Sharma, Manu, Thomas Rudel, Froelich, C., Sharma, M., Monique Oswald, Froelich, Christopher J., Oliver Thieck, Rajalingam, Krishnaraj, Rudel Thomas, Thieck Oliver, Thieck, Oliver, Oswald, Monique, Froelich Christopher J., Rajalingam, K., Lohmann Christine, Rudel, T., Thieck, O., Rudel, Thomas, Krishnaraj Rajalingam, Rajalingam Krishnaraj, Lohmann, Christine   +27 more
core   +2 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

SPINK13 acts as a tumor suppressor in hepatocellular carcinoma by inhibiting Akt phosphorylation

Cell Death and Disease
The PI3K/Akt pathway is overexpressed in nearly 50% of hepatocellular carcinomas and inhibits apoptosis by promoting the expression of antiapoptotic genes. Serine protease inhibitors have been shown to induce apoptosis in hepatoma cells by downregulating
Yongzhi Lun, Jie Sun, Ling Wei, Ben Liu, Zhixue Li, Wen Dong, Wenqi Zhao   +6 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Resveratrol-induced cell death in leukaemia cells: The effect of Hsp72 expression and combination treatments with TRAIL and ethanol [PDF]

, 2009
Resveratrol, a natural phytoalexin found in grapes and red wine, displays anti-cancer activities through a variety of mechanisms that include the induction of cancer cell apoptosis.
Weaver, Annette S.
core   +2 more sources

IAP-IAP complexes required for apoptosis resistance of C. trachomatis-infected cells [PDF]

, 2006
Host cells infected with obligate intracellular bacteria Chlamydia trachomatis are profoundly resistant to diverse apoptotic stimuli. The molecular mechanisms underlying the block in apoptotic signaling of infected cells is not well understood.
Manu Sharma, Nicole Paland, Nikolaus Machuy, Thieck, Oliver, Oswald, Monique, Robert Hurwitz, Oswald, M., Machuy, Nikolaus, Sharma, Manu, Thomas Rudel, Rajalingam, K., Sharma, M., Monique Oswald, Rudel, T., Paland, Nicole, Thieck, O., Rudel, Thomas, Oliver Thieck, Hurwitz, Robert, Krishnaraj Rajalingam, Paland, N., Machuy, N., Rajalingam, Krishnaraj, Hurwitz, R.   +23 more
core   +2 more sources