Results 31 to 40 of about 3,365,976 (292)

Sinomenine Hydrochloride Can Ameliorate Benign Prostatic Hyperplasia by Lowering the 5α-Reductase 2 Level and Regulating the Balance between the Proliferation and Apoptosis of Cells

Molecules, 2023
Benign prostatic hyperplasia (BPH) is a chronic disease that affects the quality of life of older males. Sinomenine hydrochloride (SIN) is the major bioactive alkaloid isolated from the roots of the traditional Chinese medicinal plant Sinomenium acutum ...
Mao-Si Fan, Yue-Fei Xia, Rui-Han Ye, Ze-Rui Sun, Ming-Yue Wang, Meng-Fei An, Shao-Shi Zhang, Li-Juan Zhang, Yun-Li Zhao, Ze-Min Xiang, Jun Sheng   +10 more
doaj   +1 more source

Glycosylation of Candida albicans cell wall proteins is critical for induction of innate immune responses and apoptosis of epithelial cells. [PDF]

, 2012
C. albicans is one of the most common fungal pathogen of humans, causing local and superficial mucosal infections in immunocompromised individuals. Given that the key structure mediating host-C.
Tilo Biedermann (116048), Jeanette Wagener (116035), Weig, Michael S., Susanne Kaesler (116042), Jeanette Wagener, Bader, Oliver, Schaller, Martin, Albert D. de Boer (116041), Naglik, Julian R., Naglik, Julian R, Piet W. J. de Groot (116040), Daniela Mailänder-Sanchez (116045), Weindl, Günther, Julian R Naglik, Hans Christian Korting (116050), Günther Weindl, Martin Schaller, Julian R. Naglik (116049), Selvam Thavaraj (116043), Albert D de Boer, Oliver Bader, Hans Christian Korting, de Boer, Albert D, Albert D. De Boer, Oliver Bader (116044), Claudia Borelli (116046), Selvam Thavaraj, Borelli, Claudia, Daniela Mailänder-Sanchez, Susanne Kaesler, Günther Weindl (116038), Biedermann, Tilo, Michael Weig, Michael Weig (116047), Claudia Borelli, de Boer, Albert D., Weindl, Guenther, Mailaender-Sanchez, Daniela, Julian R. Naglik, Kaesler, Susanne, de Groot, Piet W. J., Thavaraj, Selvam, Korting, Hans Christian, Mailänder-Sanchez, Daniela, Apoptosis Of Epithelial Cells, Piet W. J. De Groot, Martin Schaller (116051), Wagener, Jeanette, Weig, Michael, Tilo Biedermann, Piet W J de Groot, Naglik, Julian R; id_orcid, de Groot, Piet W J, Bader Oliver, Biedermann Tilo, Naglik Julian R., Weig Michael, Korting Hans Christian, Schaller Martin, de Groot Piet W. J., Kaesler Susanne, Mailänder-Sanchez Daniela, Borelli Claudia, Mailänder-Sánchez, Daniela Isabel, Thavaraj Selvam, Weindl Günther, Wagener Jeanette, de Boer Albert D.   +67 more
core   +1 more source

Shifting the balance of mitochondrial apoptosis: therapeutic perspectives [PDF]

, 2012
Signaling via the intrinsic (mitochondrial) pathway of apoptosis represents one of the critical signal transduction cascades that control the regulation of cell death.
Simone Fulda, Simone eFulda, Fulda, Simone   +2 more
core   +1 more source

Apoptosis regulatory protein–protein interaction demonstrates hierarchical scale-free fractal network [PDF]

Briefings in Bioinformatics, 2014
Dysregulation or inhibition of apoptosis favors cancer and many other diseases. Understanding of the network interaction of the genes involved in apoptotic pathway, therefore, is essential, to look for targets of therapeutic intervention. Here we used the network theory methods, using experimentally validated 25 apoptosis regulatory proteins and ...
Shazia Nafis, Ponnusamy Kalaiarasan, R. K. Brojen Singh, Mohammad Husain, Rameshwar N. K. Bamezai   +4 more
openaire   +3 more sources

Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-β-dependent induction of pro-apoptotic Noxa. [PDF]

, 2011
Viral infection is a stimulus for apoptosis, and in order to sustain viral replication many viruses are known to carry genes encoding apoptosis inhibitors. F1L, encoded by the orthopoxvirus modified vaccinia virus Ankara (MVA) has a Bcl-2-like structure.
Potthoff, Stephanie, Häcker Georg, Sutter Gerd, Kastenmüller, Wolfgang, Drexler, I., Eitz Ferrer Pedro, Ludwig, H., Gasteiger Georg, Sutter, G., Gasteiger, Georg, Holger Ludwig, Stefan A Paschen, Stefan A. Paschen, Stephanie Potthoff, Potthoff, S., Susanne Kirschnek, Kirschnek, Susanne, Kastenmüller Wolfgang, Pedro Eitz Ferrer, Kirschnek, S., Häcker, Georg, Potthoff Stephanie, Villunger Andreas, Georg Gasteiger, Villunger, A., Ludwig, Holger, Georg Häcker, Drexler Ingo, Wolfgang Kastenmüller, Villunger, Andreas, Ingo Drexler, Gasteiger, G., Paschen, Stefan A., Sutter, Gerd, Häcker, G., Eitz Ferrer, Pedro, Kastenmüller, W., Kirschnek Susanne, Paschen Stefan A., Gerd Sutter, Ludwig Holger, Paschen, S.A., Andreas Villunger, Eitz Ferrer, P., Drexler, Ingo, Eitz Ferrer, P;Potthoff, S;Kirschnek, S;Gasteiger, G;Kastenmuller, W;Ludwig, H;Paschen, SA;Villunger, A;Sutter, G;Drexler, I;Häcker, G   +45 more
core   +2 more sources

Identification and Characterization of a Cell Cycle and Apoptosis Regulatory Protein-1 as a Novel Mediator of Apoptosis Signaling by Retinoid CD437 [PDF]

Journal of Biological Chemistry, 2003
CD437, a novel retinoid, causes cell cycle arrest and apoptosis in a number of cancer cells including human breast carcinoma (HBC) by utilizing an undefined retinoic acid receptor/retinoid X receptor-independent mechanism. To delineate mediators of CD437 signaling, we utilized a random antisense-dependent functional knockout genetic approach.
Arun K, Rishi, Liyue, Zhang, Madanamohan, Boyanapalli, Anil, Wali, Ramzi M, Mohammad, Yingjie, Yu, Joseph A, Fontana, James S, Hatfield, Marcia I, Dawson, Adhip P N, Majumdar, Uwe, Reichert   +10 more
openaire   +2 more sources

MicroRNA-494-3p prevents liver fibrosis and attenuates hepatic stellate cell activation by inhibiting proliferation and inducing apoptosis through targeting TRAF3

Annals of Hepatology, 2021
Introduction and objectives: Alcoholic hepatitis (AH) is characterized by high morbidity and mortality. MicroRNA-494-3p is possibly involved in the regulation of cancers, but its role in AH has been rarely studied.
Hualong Li, Lei Zhang, Nan Cai, Bing Zhang, Shaomei Sun   +4 more
doaj   +1 more source

Bacterial porin disrupts mitochondrial membrane potential and sensitizes host cells to apoptosis [PDF]

, 2009
The bacterial PorB porin, an ATP-binding beta-barrel protein of pathogenic Neisseria gonorrhoeae, triggers host cell apoptosis by an unknown mechanism. PorB is targeted to and imported by host cell mitochondria, causing the breakdown of the mitochondrial
Kepp, Oliver, Meinecke, M., Harsman, Anke, Meinecke, Michael, Joachim Rassow, Hauf, Eva, Kepp, O., Günther, Dirk, Oliver Kepp, Richard Wagner, Dirk Günther, Thomas Rudel, Hauf, E., Wagner, R., Katharina Ross, Rassow, Joachim, Volker Brinkmann, Brinkmann, Volker, Rajalingam, Krishnaraj, Ines Herrmann, Elke A. Dian-Lothrop, Brinkmann, V., Kozjak-Pavlovic, V., Günther, D., Kozjak-Pavlovic, Vera, Ross, Katharina, Eva Hauf, Vera Kozjak-Pavlovic, Michael Meinecke, Robert Hurwitz, Dian-Lothrop, E., Wagner, Richard, Ross, K., Rajalingam, K., Rudel, T., Dian-Lothrop, Elke A., Rudel, Thomas, Hurwitz, Robert, Krishnaraj Rajalingam, Harsman, A., Elke A Dian-Lothrop, Herrmann, I., Hurwitz, R., Herrmann, Ines, Rassow, J., Anke Harsman   +45 more
core   +2 more sources

System in biology leading to cell pathology: stable protein-protein interactions after covalent modifications by small molecules or in transgenic cells

Journal of Biomedical Science, 2011
Background The physiological processes in the cell are regulated by reversible, electrostatic protein-protein interactions. Apoptosis is such a regulated process, which is critically important in tissue homeostasis and development and leads to complete ...
Malina Halina Z
doaj   +1 more source

Targeting apoptosis signaling in pancreatic cancer [PDF]

, 2011
The ability to escape apoptosis or programmed cell death is a hallmark of human cancers, for example pancreatic cancer. This can promote tumorigenesis, since too little cell death by apoptosis disturbs tissue homeostasis.
Simone Fulda, Fulda, Simone
core   +1 more source