Results 31 to 40 of about 446,328 (302)

Caenorhabditis elegans protein arginine methyltransferase PRMT-5 negatively regulates DNA damage-induced apoptosis. [PDF]

PLoS Genetics, 2009
Arginine methylation of histone and non-histone proteins is involved in transcription regulation and many other cellular processes. Nevertheless, whether such protein modification plays a regulatory role during apoptosis remains largely unknown.
Mei Yang, Jianwei Sun, Xiaojuan Sun, Qinfang Shen, Zhiyang Gao, Chonglin Yang   +5 more
doaj   +1 more source

IAPs on the move : role of inhibitors of apoptosis proteins in cell migration

, 2013
Inhibitors of Apoptosis Proteins (IAPs) are a class of highly conserved proteins predominantly known for the regulation of caspases and immune signaling. However, recent evidence suggests a crucial role for these molecules in the regulation of tumor cell
Oberoi-Khanuja, Tripat Kaur, Murali, Arun, Rajalingam, Krishnaraj   +2 more
core   +1 more source

Ubiquitination of Nonhistone Proteins in Cancer Development and Treatment

Frontiers in Oncology, 2021
Ubiquitination, a crucial post-translation modification, regulates the localization and stability of the substrate proteins including nonhistone proteins. The ubiquitin-proteasome system (UPS) on nonhistone proteins plays a critical role in many cellular
Xiuzhen Zhang, Tong Meng, Shuaishuai Cui, Ling Feng, Dongwu Liu, Dongwu Liu, Qiuxiang Pang, Ping Wang   +7 more
doaj   +1 more source

Dual inhibition of BET and HAT/p300 suppresses colorectal cancer via DR5- and p53/PUMA-mediated cell death

Frontiers in Oncology, 2022
BackgroundColorectal cancer (CRC) frequently has a dysregulated epigenome causing aberrant up-regulation of oncogenes such as c-MYC. Bromodomain and extra-terminal domain (BET) proteins and histone acetyltransferases (HAT) are epigenetic regulatory ...
Chaoyuan Kuang, Chaoyuan Kuang, Jingshan Tong, Jingshan Tong, Kaylee Ermine, Kaylee Ermine, Manbo Cai, Manbo Cai, Fujun Dai, Fujun Dai, Suisui Hao, Suisui Hao, Francis Giles, Yi Huang, Yi Huang, Jian Yu, Jian Yu, Lin Zhang, Lin Zhang   +18 more
doaj   +1 more source

3p21.3 tumor suppressor gene RBM5 inhibits growth of human prostate cancer PC-3 cells through apoptosis

World Journal of Surgical Oncology, 2012
Background Recent studies have indicated that the nuclear RNA-binding protein RBM5 has the ability to modulate apoptosis and suppress tumor growth. The aim of this study is to investigate the expression of RBM5 in human prostate cancer and its mechanism ...
Zhao Lijing, Li Ranwei, Shao Chen, Li Ping, Liu Jian, Wang Ke   +5 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

GAS5 Long Noncoding RNA Regulates CD20 Expression and Rituximab Response [PDF]

Advanced Pharmaceutical Bulletin
Purpose: Rituximab is the primary treatment for non-Hodgkin lymphoma (NHL), one of the most common cancers globally. One of the main challenges associated with rituximab therapy is the decline in its effectiveness over time.
Mahbubeh Rojhannezhad, Zahra Abedi Kichi, Abbas Nikravesh, Mehrdad Behmanesh   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

LIFEGUARD proteins support plant colonization by biotrophic powdery mildew fungi [PDF]

, 2013
Pathogenic microbes manipulate eukaryotic cells during invasion and target plant proteins to achieve host susceptibility. BAX INHIBITOR-1 (BI-1) is an endoplasmic reticulum-resident cell death suppressor in plants and animals and is required for full ...
Huckelhoven, Ralph, Eichmann, Ruth, Weis, Corina   +2 more
core   +1 more source

Integrating protein interaction and pathway crosstalk network reveals a promising therapeutic approach for psoriasis through apoptosis induction

Scientific Reports
Psoriasis is a complex inflammatory skin disease manifested by altered proliferation and differentiation of keratinocytes with dysfunctional apoptosis.
Masoumeh Farahani, Reza M. Robati, Mostafa Rezaei-Tavirani, Fatemeh Fateminasab, Sergey Shityakov, Mohammad Rahmati Roodsari, Zahra Razzaghi, Mona Zamanian Azodi, Saviz Saghari   +8 more
doaj   +1 more source