Role of Cell Cycle Regulatory Proteins in Cerebellar Granule Neuron Apoptosis [PDF]
The Journal of Neuroscience, 1999 Cerebellar granule neurons (CGNs) undergo apoptosis when deprived of depolarizing concentrations of KCl, but the underlying molecular mechanisms are not yet clear. Although caspases have been postulated to be involved in CGN cell death, inhibitors of caspases failed to prevent apoptosis under our culture conditions, suggesting an involvement of other ...
J, Padmanabhan +3 more
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RNA virus modulation of IFN, PI3K and apoptosis [PDF]
, 2009 Interferon (IFN) and phosphatidylinositol 3-kinase (PI3K) are apoptosis regulators that are targeted by viruses to promote survival of infected cells.
Killip, Marian J.
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Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis. [PDF]
, 2015 The loss of photoreceptors is the defining characteristic of many retinal degenerative diseases, but the mechanisms that regulate photoreceptor cell death are not fully understood.
Dimitrios Stampoulis +11 more
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Expression proteomics predicts loss of RXR-γ during progression of epithelial ovarian cancer. [PDF]
PLoS ONE, 2013 The process of cellular transformation involves cascades of molecular changes that are modulated through altered epigenetic, transcription, post-translational and protein regulatory networks.
Rajkumar S Kalra, Sharmila A Bapat
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Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin [PDF]
Nature Cell Biology, 2009 Physiological oxidants that are generated by activated phagocytes comprise the main source of oxidative stress during inflammation. Oxidants such as taurine chloramine (TnCl) and hydrogen peroxide (H(2)O(2)) can damage proteins and induce apoptosis, but the role of specific protein oxidation in this process has not been defined. We found that the actin-
Fábio, Klamt +8 more
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IAPs on the move : role of inhibitors of apoptosis proteins in cell migration [PDF]
, 2013 Inhibitors of Apoptosis Proteins (IAPs) are a class of highly conserved proteins predominantly known for the regulation of caspases and immune signaling. However, recent evidence suggests a crucial role for these molecules in the regulation of tumor cell
Oberoi-Khanuja, Tripat Kaur +2 more
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Cell Cycle- and Apoptosis-regulatory Protein-1 Is Involved in Apoptosis Signaling by Epidermal Growth Factor Receptor [PDF]
Journal of Biological Chemistry, 2006 CARP-1, a novel apoptosis inducer, regulates apoptosis signaling by diverse agents, including adriamycin and growth factors. Epidermal growth factor receptor (EGFR)-related protein (ERRP), a pan-ErbB inhibitor, inhibits EGFR and stimulates apoptosis. Treatments of cells with ERRP or Iressa (an EGFR tyrosine kinase inhibitor) results in elevated CARP-1 ...
Arun K, Rishi +8 more
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Bim and Bmf synergize to induce apoptosis in Neisseria gonorrhoeae infection [PDF]
, 2009 : Bcl-2 family proteins including the pro-apoptotic BH3-only proteins are central regulators of apoptotic cell death. Here we show by a focused siRNA miniscreen that the synergistic action of the BH3-only proteins Bim and Bmf is required for apoptosis ...
Kepp, Oliver +23 more
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Viral control of mitochondrial apoptosis. [PDF]
PLoS Pathogens, 2008 Throughout the process of pathogen-host co-evolution, viruses have developed a battery of distinct strategies to overcome biochemical and immunological defenses of the host. Thus, viruses have acquired the capacity to subvert host cell apoptosis, control
Lorenzo Galluzzi +4 more
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Inhibitor of Apoptosis Proteins as Novel Targets in Inflammatory Processes [PDF]
, 2013 Objective: Inhibitor of apoptosis proteins (IAPs), such as X-linked or cellular IAP 1/2 (XIAP, cIAP1/2), are important regulators of apoptosis. IAP antagonists are currently under clinical investigation as anticancer agents.
Mayer, Bettina A. +10 more
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