Results 21 to 30 of about 446,328 (302)

Viral control of mitochondrial apoptosis. [PDF]

PLoS Pathogens, 2008
Throughout the process of pathogen-host co-evolution, viruses have developed a battery of distinct strategies to overcome biochemical and immunological defenses of the host. Thus, viruses have acquired the capacity to subvert host cell apoptosis, control
Lorenzo Galluzzi, Catherine Brenner, Eugenia Morselli, Zahia Touat, Guido Kroemer   +4 more
doaj   +1 more source

Sinomenine Hydrochloride Can Ameliorate Benign Prostatic Hyperplasia by Lowering the 5α-Reductase 2 Level and Regulating the Balance between the Proliferation and Apoptosis of Cells

Molecules, 2023
Benign prostatic hyperplasia (BPH) is a chronic disease that affects the quality of life of older males. Sinomenine hydrochloride (SIN) is the major bioactive alkaloid isolated from the roots of the traditional Chinese medicinal plant Sinomenium acutum ...
Mao-Si Fan, Yue-Fei Xia, Rui-Han Ye, Ze-Rui Sun, Ming-Yue Wang, Meng-Fei An, Shao-Shi Zhang, Li-Juan Zhang, Yun-Li Zhao, Ze-Min Xiang, Jun Sheng   +10 more
doaj   +1 more source

Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin [PDF]

Nature Cell Biology, 2009
Physiological oxidants that are generated by activated phagocytes comprise the main source of oxidative stress during inflammation. Oxidants such as taurine chloramine (TnCl) and hydrogen peroxide (H(2)O(2)) can damage proteins and induce apoptosis, but the role of specific protein oxidation in this process has not been defined. We found that the actin-
Fábio, Klamt, Stéphanie, Zdanov, Rodney L, Levine, Ashley, Pariser, Yaqin, Zhang, Baolin, Zhang, Li-Rong, Yu, Timothy D, Veenstra, Emily, Shacter   +8 more
openaire   +2 more sources

Functional characterization of human NDR kinases : novel regulatory mechanisms and a path towards direct substrates [PDF]

, 2012
Protein kinases are important regulators of signal transduction pathways in both unicellular and multicellular organisms. They play critical roles in biological processes such as cell growth, division, differentiation, adhesion, motility and cell death ...
Kohler, Reto
core   +1 more source

Cell Cycle- and Apoptosis-regulatory Protein-1 Is Involved in Apoptosis Signaling by Epidermal Growth Factor Receptor [PDF]

Journal of Biological Chemistry, 2006
CARP-1, a novel apoptosis inducer, regulates apoptosis signaling by diverse agents, including adriamycin and growth factors. Epidermal growth factor receptor (EGFR)-related protein (ERRP), a pan-ErbB inhibitor, inhibits EGFR and stimulates apoptosis. Treatments of cells with ERRP or Iressa (an EGFR tyrosine kinase inhibitor) results in elevated CARP-1 ...
Arun K, Rishi, Liyue, Zhang, Yingjie, Yu, Yan, Jiang, Jyoti, Nautiyal, Anil, Wali, Joseph A, Fontana, Edi, Levi, Adhip P N, Majumdar   +8 more
openaire   +2 more sources

Main Pro-Apoptotic Member of BCL-2 Family Proteins-BAX [PDF]

, 2010
Programmed cell death (apoptosis) plays a vital role in the regulation of cellular homeostasis. Because of apoptosis fundamental importance, this process is highly regulated.
Kiliańska, Zofia, Zofia Maria Kiliańska, Kiliańska, Zofia Maria, Jolanta Dominika Żołnierczyk, Żołnierczyk, Jolanta Dominika, Żolnierczyk, Jolanta   +5 more
core   +1 more source

MicroRNA-494-3p prevents liver fibrosis and attenuates hepatic stellate cell activation by inhibiting proliferation and inducing apoptosis through targeting TRAF3

Annals of Hepatology, 2021
Introduction and objectives: Alcoholic hepatitis (AH) is characterized by high morbidity and mortality. MicroRNA-494-3p is possibly involved in the regulation of cancers, but its role in AH has been rarely studied.
Hualong Li, Lei Zhang, Nan Cai, Bing Zhang, Shaomei Sun   +4 more
doaj   +1 more source

System in biology leading to cell pathology: stable protein-protein interactions after covalent modifications by small molecules or in transgenic cells

Journal of Biomedical Science, 2011
Background The physiological processes in the cell are regulated by reversible, electrostatic protein-protein interactions. Apoptosis is such a regulated process, which is critically important in tissue homeostasis and development and leads to complete ...
Malina Halina Z
doaj   +1 more source

Apoptosis regulatory protein–protein interaction demonstrates hierarchical scale-free fractal network [PDF]

Briefings in Bioinformatics, 2014
Dysregulation or inhibition of apoptosis favors cancer and many other diseases. Understanding of the network interaction of the genes involved in apoptotic pathway, therefore, is essential, to look for targets of therapeutic intervention. Here we used the network theory methods, using experimentally validated 25 apoptosis regulatory proteins and ...
Shazia Nafis, Ponnusamy Kalaiarasan, R. K. Brojen Singh, Mohammad Husain, Rameshwar N. K. Bamezai   +4 more
openaire   +2 more sources

Identification and Characterization of a Cell Cycle and Apoptosis Regulatory Protein-1 as a Novel Mediator of Apoptosis Signaling by Retinoid CD437 [PDF]

Journal of Biological Chemistry, 2003
CD437, a novel retinoid, causes cell cycle arrest and apoptosis in a number of cancer cells including human breast carcinoma (HBC) by utilizing an undefined retinoic acid receptor/retinoid X receptor-independent mechanism. To delineate mediators of CD437 signaling, we utilized a random antisense-dependent functional knockout genetic approach.
Arun K, Rishi, Liyue, Zhang, Madanamohan, Boyanapalli, Anil, Wali, Ramzi M, Mohammad, Yingjie, Yu, Joseph A, Fontana, James S, Hatfield, Marcia I, Dawson, Adhip P N, Majumdar, Uwe, Reichert   +10 more
openaire   +2 more sources