Results 71 to 80 of about 446,328 (302)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Immunotherapeutic targeting of membrane Hsp70-expressing tumors using recombinant human granzyme B [PDF]

, 2012
Background: We have previously reported that human recombinant granzyme B (grB) mediates apoptosis in membrane heat shock protein 70 (Hsp70)-positive tumor cells in a perforin-independent ...
Axel Walch, Alan G Pockley, Foulds, GA, Pockley, A. G., Foulds, G. A., Doss, B. T., Pockley, AG, Stangl Stefan, Kirschner, A., Foulds, G.A., Gehrmann, M., Multhoff, G., Walch Axel, Doß Brigitte T., Walch, A.K., Kirschner, A, Gehrmann Mathias, Gemma A Foulds, Stangl, S., Walch, A., Doß, B.T., Pockley, A.G., Multhoff, G, Sievert Wolfgang, Stefan Stangl, Stangl, S, Pockley Alan G., Mathias Gehrmann, Multhoff Gabriele, Sievert, W, Sievert, W., Foulds Gemma A., Andreas Kirschner, Kirschner Andreas, Wolfgang Sievert, Gehrmann, M, Gabriele Multhoff, Doß, BT, Brigitte T Doss, Walch, A   +39 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

MIRTFnet: analysis of miRNA regulated transcription factors. [PDF]

, 2011
Several expression datasets of miRNA transfection experiments are available to analyze the regulatory mechanisms downstream of miRNA effects. The miRNA induced regulatory effects can be propagated via transcription factors (TFs).
Küffner, Robert, Ralf Zimmer, Naeem, Haroon, Robert Küffner, Küffner Robert, Zimmer, R, Naeem Haroon, Naeem, H, Küffner, R, Zimmer, Ralf, Zimmer Ralf, Haroon Naeem   +11 more
core   +1 more source

Regulation of apoptosis, ferroptosis, and pyroptosis mediated by acetylation

Cell Death Discovery
Acetylation is an important post-translational modification (PTM) of proteins and plays critical roles in multiple biological processes. The modes of cell death represent different pathways leading to the final outcome of “death” for the cell, with ...
Weijie Lu, Yaoting Deng, Mengyang Liu, Yujie Hu, Kang Yang, Bowen Wang, Yanling Li, Gang Wang, Li Ma, Jiajia Liu, Yaohui Xie, Qianrong Li, Ai Liu, Xiubin Zhang, Ping Xie   +14 more
doaj   +1 more source

Apoptosis Inhibitor 5: A Multifaceted Regulator of Cell Fate

Biomolecules
Apoptosis, or programmed cell death, is a fundamental process that maintains tissue homeostasis, eliminates damaged or infected cells, and plays a crucial role in various biological phenomena.
Hafsia Abbas, Dalia Kheira Derkaoui, Louise Jeammet, Emilie Adicéam, Jérôme Tiollier, Hélène Sicard, Thorsten Braun, Jean-Luc Poyet   +7 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Identification of Novel Genes and Pathways Regulating SREBP Transcriptional Activity.

, 2009
BACKGROUND: Lipid metabolism in mammals is orchestrated by a family of transcription factors called sterol regulatory element-binding proteins (SREBPs) that control the expression of genes required for the uptake and synthesis of cholesterol, fatty acids,
Craig Mickanin, Dev Kumlesh K., Nanguneri, NR, Joseph D Szustakowski, Szustakowski Joseph D., Sivasankaran Rajeev, Sivasankaran, R, Mickanin Craig, Labow, MA, Nanguneri Nirmala R., Rajeev Sivasankaran, Mickanin, C, Nohturfft, A, Mark A Labow, Nohturfft Axel, Nirmala R Nanguneri, Kumlesh K Dev, Labow Mark A., Szustakowski, JD, Chatterjee Sandipan, Sandipan Chatterjee, Chatterjee, S, Dev, KK, Axel Nohturfft   +23 more
core   +1 more source

Helicobacter pylori Membrane Vesicles Stimulate Innate Pro- and Anti-Inflammatory Responses and Induce Apoptosis in Jurkat T Cells [PDF]

, 2014
Persistent Helicobacter pylori infection induces chronic inflammation in the human gastric mucosa, which is associated with development of peptic ulceration, gastric atrophy, and gastric adenocarcinoma.
Winter, J, Rhead, J, Atherton, J, Winter, Jody, Atherton, John, Letley, D, Rhead, Joanne, Letley, Darren, Robinson, Karen, Robinson, K   +9 more
core   +1 more source

The differential roles of Giardia duodenalis-secreted tenascins in inducing intestinal epithelial cell apoptosis and the attributed EGFR-STAT3 axis regulation.

PLoS Neglected Tropical Diseases
Giardia duodenalis is an important extracellular protozoan parasite of the gut responsible for waterborne diarrhea in human and nonhuman animals worldwide. Giardia trophozoites express and secrete excretory-secretory proteins (ESPs) affecting structural,
Shui Yu, Zhepeng Sun, Yiqi Wang, Peipei Zhang, Hongxing Sun, Ziqi Meng, Chufan Yang, Yu Shen, Zhanhao Guo, Wei Li   +9 more
doaj   +1 more source