Results 71 to 80 of about 3,365,976 (292)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A new inhibitor of apoptosis from vaccinia virus and eukaryotes. [PDF]

, 2007
A new apoptosis inhibitor is described from vaccinia virus, camelpox virus, and eukaryotic cells. The inhibitor is a hydrophobic, multiple transmembrane protein that is resident in the Golgi and is named GAAP (Golgi anti-apoptotic protein).
Hollinshead, M, Smith, GL, van Kuppeveld, FJM, van Kuppeveld Frank J. M, Lu, X., Smith, G.L., Xin Lu, Gubser, C, Smith Geoffrey L, Bergamaschi, D., Bergamaschi Daniele, Hollinshead Michael, Caroline Gubser, Hollinshead, M., van Kuppeveld, FJ, Bergamaschi, D, Kuppeveld, F.J.M. van, Gubser Caroline, Geoffrey L Smith, Gubser, C., Frank J M van Kuppeveld, Michael Hollinshead, Lu Xin, Daniele Bergamaschi, Lu, Xin, Lu, X   +25 more
core   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Regulation of Mitochondria-dependent Apoptosis in Non-Small Cell Lung Cancer: Implications for Cancer Therapy [PDF]

, 2007
Summary The work described in this thesis focuses on the characterization of the mechanism(s) underlying the deregulated activation of the intrinsic or mitochondrial apoptotic pathway in non-small cell lung cancer (NSCLC) cells.
Checinska, A.
core  

Trim17, novel E3 ubiquitin-ligase, initiates neuronal apoptosis [PDF]

, 2010
Accumulating data indicate that the ubiquitin-proteasome system controls apoptosis by regulating the level and the function of key regulatory proteins. In this study, we identified Trim17, a member of the TRIM/RBCC protein family, as one of the critical ...
Rahmeh, R, Magiera, M, Ham, Jonathan, M Kristiansen, Kristiansen, Mark, Ham, J, Desagher, Solange, Lipkin, A, Desagher, S., Rahmeh, Rita, Mora, Stéphan, M M Magiera, Vanhille, Laurent, Pettmann, B, Lipkin, Alexey, Mora, S, Lipkin, A., Kristiansen, M, Robbins, Ian, S Mora, Ham, J., R Rahmeh, Rahmeh, R., A Lipkin, Pettmann, Brigitte, Robbins, I., Mora, S., Lassot, I., Desagher, S, Lassot, I, Magiera, Maria Magdalena, Magiera, M. M., L Vanhille, Jaudon, F, I Lassot, Vanhille, L., Jaudon, F., S Desagher, Jaudon, Fanny, Lassot, Irina, Kristiansen, M., F Jaudon, Pettmann, B., Vanhille, L, Robbins, I, J Ham, I Robbins, B Pettmann   +47 more
core   +1 more source

Effects of antipsychotics, haloperidol and olanzapine, on the expression of apoptosis-related genes in mouse mHippoE-2 cells and rat hippocampus

Endocrine Regulations, 2023
Objective. Modified levels of pro- (caspase3, Bax) and anti-apoptotic (Bcl-2) regulatory proteins have been detected in certain brain areas of schizophrenic patients indicating a possible dysregulation of apoptosis.
Osacka Jana, Kiss Alexander, Bacova Zuzana, Tillinger Andrej   +3 more
doaj   +1 more source

Expression of regulatory and executor proteins of apoptosis in odontogenic keratocyst: a systematic review

Medicina Oral Patología Oral y Cirugia Bucal
The odontogenic keratocyst (OKC) corresponds to the third most common odontogenic cyst of the maxillary bones, originating from the dental lamina or its remnants. Apoptosis dysregulation, due to an imbalance between anti-apoptotic and proapoptotic proteins, has been proposed as a promoter for the development and progression of OKC.
Martínez-Flores, René, Muñoz-Orrego, Matías, Marín-Márquez, Constanza, Schuch, Lauren F., Silveira, Felipe Martins, Bologna Molina, Ronell, Niklander, Sven   +6 more
openaire   +3 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A Chromatin-Focused siRNA Screen for Regulators of p53-Dependent Transcription

G3: Genes, Genomes, Genetics, 2016
The protein product of the Homo sapiens TP53 gene is a transcription factor (p53) that regulates the expression of genes critical for the response to DNA damage and tumor suppression, including genes involved in cell cycle arrest, apoptosis, DNA repair ...
Morgan A. Sammons, Jiajun Zhu, Shelley L. Berger   +2 more
doaj   +1 more source

Diverse maturity-dependent and complementary anti-apoptotic brakes safeguard human iPSC-derived neurons from cell death

Cell Death and Disease, 2022
In humans, most neurons are born during embryonic development and have to persist throughout the entire lifespan of an individual. Thus, human neurons have to develop elaborate survival strategies to protect against accidental cell death.
Ruven Wilkens, Anne Hoffrichter, Karolina Kleinsimlinghaus, Bettina Bohl, Carolin Haag, Nadja Lehmann, Malin Schmidt, Elena Muñoz Perez-Vico, Julia Wangemann, Klara Franziska Rehder, Sandra Horschitz, Georg Köhr, Julia Ladewig, Philipp Koch   +13 more
doaj   +1 more source