Results 1 to 10 of about 84 (75)

Nöroblastoma Hücre Hattında Uzun Süreli Darbeli Elektromanyetik Alan Maruziyetinin Apoptoz Üzerine Etkileri

open access: yesSüleyman Demirel Üniversitesi Fen-Edebiyat Fakültesi Fen Dergisi, 2023
Darbeli Elektromanyetik Alan (PEMF) düşük frekanslı elektromanyetik alan olup son yıllarda klinik araştırmalarda tedavi amaçlı uygulanmasına yönelik çalışmalar hız kazanmıştır.
Serdar Karakurt   +2 more
doaj   +1 more source

Combined effect of midostaurin and sphingosine kinase-1 inhibitor on FMS-like tyrosine kinase 3 (FLT3) wild type acute myeloid leukemia cells

open access: yesTürk Biyokimya Dergisi, 2022
Therapeutic potential of clinically approved FLT3 inhibitor midostaurin has been neglected in wild-type FLT3 positive acute myeloid leukemia (AML). Sphingosine kinase-1 (SK-1) having anti-proliferative functions is studied in various cancers, but not in ...
Şahin Hande Nur, Adan Aysun
doaj   +1 more source

HÜCRE KÜLTÜRÜ ORTAMINDA KARVAKROLÜN KOBALT KLORÜR İLE İNDÜKLENEN KİMYASAL HİPOKSİDEKİ KORUYUCU ROLÜ

open access: yesSüleyman Demirel Üniversitesi Tıp Fakültesi Dergisi, 2023
AmaçHipoksi nöronal hasar açısından en önemli faktörlerdenbiridir. Nöronlarda eksprese edilen TRPM7 katyonkanallarının hipoksi ve hücresel pH değişimleridahil birçok faktörle aktive olduğu bilinmektedir.
Ahmi Öz
doaj   +1 more source

Apoptotik Yolaklar ve Hedefe Yönelik Tedaviler

open access: yesSüleyman Demirel Üniversitesi Tıp Fakültesi Dergisi, 2020
Fizyolojik ve patolojik durumlarda, işleyişleri farklı, nekroz ve apoptoz olarak adlandırılan iki ana hücre ölümü meydana gelir. Apoptoz basamaklarındaki disregülasyonun kanser veya otoimmüniteyi tetiklediği bildirilmiş olup, aşırı apoptoz ise ...
Aylin Gökhan   +4 more
doaj   +1 more source

Is Enoxaparin Sodium Exactly Safe For Subcutaneous Fibroblast?: A Cell Culture Study

open access: yesActa Medica Alanya, 2021
Aim: Despite relatively low amount in the subcutaneous tissue, fibroblasts play a critical role in the continuity of intercellular connections, maintenance of tissue integrity, and forming a balanced fascial network.
Mehmet Ali Onur   +5 more
doaj   +1 more source

The musculoprotective effects of thymoquinone on ameliorating soleus muscle damage induced by valproic acid in rats

open access: yesAdıyaman Üniversitesi Sağlık Bilimleri Dergisi, 2022
Aim: To determine the potential musculoprotective effects of thymoquinone (TQ) on valproic acid (VPA)-induced muscle damage.Materials and Methods: Twenty-one male Spraque-Dawley rats were randomly separated into 3 groups (n = 7): Control, VPA, VPA + TQ ...
Deniz Taştemir Korkmaz   +4 more
doaj   +1 more source

The evaluation of PIK3CA gene variation and serum PI3K level in breast cancer risk and prognosis in Turkish population

open access: yesTürk Biyokimya Dergisi, 2021
The PI3K (Phosphatidylinositol 3-kinase) is the member of lipid kinase family that plays important roles in tumorigenesis, cancer development and cell proliferation.
Ulu Elif   +3 more
doaj   +1 more source

Is Acteoside Effects on Colon Cancer Stem Cells Via Inflamation or Apoptosis?

open access: yesGenel Tıp Dergisi, 2022
AIM: Colon cancer is one of the main health problems worldwide. Cancer stem cells (CSCs) are referred to as tumor-initiating cells involved in tumor heterogeneity and dormancy.
Hafize Seda Vatansever   +3 more
doaj   +1 more source

Oxidative stress, DNA damage and apoptosis levels in those who use borderline high level fluoride content drinking water

open access: yesJournal of Contemporary Medicine, 2020
Aim: Fluoride is necessary for tooth and bone development, but when exposed to excessive levels can cause oxidative stress, DNA damage, apoptosis, fluorosis and cancer.
Adnan Kirmit   +4 more
doaj   +1 more source

Therapeutic Efficacy of Malachite Green-Based Photodynamic Therapy in Acute Myeloid Leukemia

open access: yesJournal of Contemporary Medicine, 2023
Aim: Acute myeloid leukemia (AML) is a disease characterized by relapse and treatment resistance in most patients. Therefore, there is a need for targeted therapies in AML.
Hüsne Özen   +5 more
doaj   +1 more source

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