Results 41 to 50 of about 991,351 (253)
Redefining organizational digitality: a relational-ontological approach inspired by new materialism
Frontiers in SociologyOrganizations, as central actors in societal structure, undergo significant transformations due to the impact of digitalization, often resulting in disruptive changes.
Linda Maack
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Application of improving swimming to the correction of joint and ligament students
Physical Education of Students, 2013 The results of research on the state-articular ligaments students engaged in physical education in primary and specialized medical group. In the experiment involved 172 students from three high schools.
V.V. Drogomeretsky +2 more
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Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Automatic system of mutually invariant vector control of mixer technology state variables
Advanced Engineering Research, 2016 The work objective is to improve the automation efficiency of the technological processes of the chemical industry and the related industries. A typical for the industry solution preparation process is considered; and the task of developing a vector ...
Rudolf A. Neydorf +1 more
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Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
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Numerical analysis of the influence of a change in the vertebral arteries joint angle on the blood flow [PDF]
Computer Methods in Materials Science, 2009 Cerebral circulation can be regarded as the most important element of blood circulation. Total ischaemia of neurotic cells, lasting longer than a few minutes, is irreversible in its consequences and results in their death. Due to that fact, blood must be
Krzysztof Jozwik +2 more
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