Results 61 to 70 of about 991,351 (253)

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Compact multi-anvil wedge-type high pressure apparatus

, 1959
Apparatus for generating high pressures by application of force by an anvil against each face of a solid polyhedron is described. The equipment constructed utilizes a tetrahedron of pyrophyllite and four tungsten carbide anvils as described earlier by H.
Lloyd, E.C. ; Hutton, U.O. ; Johnson, D.P., Lloyd, E. C.; Hutton, U.O; Johnson, D.P.   +1 more
core   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Effects of cables tension on characteristics of a gymnastics horizontal bar apparatus

Nihon Kikai Gakkai ronbunshu
In gymnastics, there is a problem in which Japanese athletes who perform well in Japan are unable to perform as well as they would like in practice or competitions overseas.
Kenya OHTSUKA, Yasushi NIGORIKAWA, Naoki ARAKAWA, Yoshio AOKI   +3 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Dispositifs à variables inconnues

Ateliers d'Anthropologie
Roleplay, speculative interaction scenarios, quirky machines, experimental platforms or experiment apparatuses can produce effects that reset a problem or question, even if (especially if) one does not control all of the variables.
Emmanuel Grimaud
doaj   +1 more source

Can a Building Be an Apparatus?

Spool, 2019
When Michel Foucault introduces the term, dispositif, commonly translated as ‘apparatus’, he uses the architectural example of the Panopticon to illustrate how power is exercised. A building, according to this line of thinking, seemingly has the capacity
Neil Leach
doaj   +1 more source

[Letter from Alex Bradford to the Oren Fire Apparatus Company - January 3, 1944]

, 1944
Letter from Alex Bradford to the Oren Fire Apparatus Company discussing Mr.
Bradford, Alex
core