Results 71 to 80 of about 127,331 (261)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

When is habitat recovered? Understanding the mechanisms of population decline to evaluate habitat recovery for boreal caribou

Conservation Science and Practice
Recovering habitat is a central objective for conserving species imperiled by habitat alteration. Yet, determining when habitat is recovered is challenging.
Craig A. DeMars, Melanie Dickie, Doug W. Lewis, Thomas J. Habib, Mark M. Wong, Robert Serrouya   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Wildlife following people: A multidisciplinary assessment of the ancient colonization of the Mediterranean Basin by a long‐lived raptor

People and Nature
Modern humans widely shaped present ecosystems through intentional and unintentional geographical redistribution of wildlife, both in historical and pre‐historical times.
Marcos Moleón, Eva Graciá, Nuria García, José M. Gil‐Sánchez, Raquel Godinho, Pedro Beja, Luís Palma, Joan Real, Antonio Hernández‐Matías, A. Román Muñoz, Eneko Arrondo, José A. Sánchez‐Zapata   +11 more
doaj   +1 more source

Dynamic capabilities in strategic choice processes within organisations

Management, 2017
Dynamic capabilities are an essential theoretical construct that is useful for understanding the phenomenon of competition. Still, in spite of the apparent popularity of this subject, the existing management literature could do with more studies into ...
Krzakiewicz Kazimierz, Cyfert Szymon
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Plant diversity alters the representation of motifs in food webs

Nature Communications, 2019
Plant diversity affects ecosystem function in myriad ways, but the effect on food webs has received less investigation. Here, the authors use high-resolution food web data from a grassland diversity experiment to show that apparent and exploitative ...
Darren P. Giling, Anne Ebeling, Nico Eisenhauer, Sebastian T. Meyer, Christiane Roscher, Michael Rzanny, Winfried Voigt, Wolfgang W. Weisser, Jes Hines   +8 more
doaj   +1 more source

Effect of Substrate Moisture Content and Invasive Grass Competition on Native Fig (Ficus fistulosa) Seedling Recruitment in Limestone Quarries

Biotropia: The Southeast Asian Journal of Tropical Biology, 2016
Challenges for restoration of degraded habitats on quarried limestone present in many countries including Indonesia. Ficus fistulosa as native species was chosen as a study species in the study of quarry restoration, as this species was shown in the ...
Annisa Satyanti
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source