Results 101 to 110 of about 361,059 (278)

Properties of small molecular drug loading and diffusion in a fluorinated PEG hydrogel studied by ^1H molecular diffusion NMR and ^(19)F spin diffusion NMR [PDF]

, 2010
R_f-PEG (fluoroalkyl double-ended poly(ethylene glycol)) hydrogel is potentially useful as a drug delivery depot due to its advanced properties of sol–gel two-phase coexistence and low surface erosion.
A Abragam, A Prabhutendolkar, AM Weljie, B Balinov, B Jeong, B Xu, BC Joondeph, CH Klein-Douwel, CS Johnson Jr, CS Johnson Jr, DG Regan, EO Stejskal, EO Stejskal, Errol V. Mathias, EV Mathias, H Yu, HC Torrey, J Jenner, J Kríž, JE Tanner, JE Tanner, Julia A. Kornfield, Julia Aponte, KI Momot, MA Voda, ML Johns, MP Krafft, MS Blumenkranz, NG Kundu, O Söderman, O Söderman, P Cornillon, PS Belton, RJ Phillips, RK Gupta, RM Cotts, S Matsukawa, S Viel, T Garasanin, T Giyoong, T Giyoong, WS Price, X Liu, Y Liao, Y Yamane, Yong Ba   +45 more
core   +3 more sources

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Variations in apparent diffusion coefficient values following chemotherapy in pediatric neuroblastoma

Diagnostic and Interventional Radiology, 2015
PURPOSEIn children the assessment of solid tumors’ response to chemotherapy is based primarily on size reduction, which can be unreliable and a late marker, in the presence of necrosis.
Senay Demir, Naime Altinkaya, Nazim Emrah Kocer, Ayse Erbay, Pelin Oguzkurt   +4 more
doaj   +1 more source

Dust settling in local simulations of turbulent protoplanetary disks

, 2006
In this paper, we study the effect of MHD turbulence on the dynamics of dust particles in protoplanetary disks. We vary the size of the particles and relate the dust evolution to the turbulent velocity fluctuations.
Fromang, S., Papaloizou, J.
core   +1 more source

In Vitro Assessment of Factors Affecting the Apparent Diffusion Coefficient of Ramos Cells Using Bio-phantoms [PDF]

, 2012
The roles of cell density, extracellular space, intracellular factors, and apoptosis induced by the molecularly targeted drug rituximab on the apparent diffusion coefficient (ADC) values were investigated using bio-phantoms.
Asaumi, Junichi, Ashida, Masakazu, Kanazawa, Susumu, Katashima, Kazunori, Kato, Hirokazu, Kuroda, Masahiro, Matsuzaki, Hidenobu, Murakami, Jun, Ohno, Seiichiro, Sasaki, Takanori   +9 more
core   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Differentiation of Orbital Lesions with Diffusion Magnetic Resonance Imaging

Ankara Üniversitesi Tıp Fakültesi Mecmuası, 2019
Objectives:The aim of this study was to determinate the ADC values of different orbital masses and to calculate the threshold ADC value for differentiation of benign and malignant masses.Materials and Methods:For this study, ADC values of 43 lesions ...
Halis Harun Öztürk, Elif Peker, Başak Gülpınar, İlhan Memet Erden   +3 more
doaj   +1 more source

Apparent diffusion coefficient by diffusion-weighted magnetic resonance imaging as a sole biomarker for staging and prognosis of gastric cancer [PDF]

, 2017
Objective: To investigate the role of apparent diffusion coefficient (ADC) from diffusion-weighted magnetic resonance imaging (DW-MRI) when applied to the 7th TNM classification in the staging and prognosis of gastric cancer (GC).
Albarello, L, Ambrosi, A, Chiari, D, De Cobelli, F, Del Maschio, A, Esposito, A, Giganti, F, Mazza, E, Orsenigo, E, Staudacher, C   +9 more
core   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

POSSIBILITIES OF DIFFUSION-WEIGHTED MAGNETIC RESONANCE IMAGING IN THE DIAGNOSIS OF SPINAL CORD TUMORS

Вестник рентгенологии и радиологии, 2018
The review analyzes the data of modern literature on main methods for the diagnosis of spinal cord tumors. It reflects the possibilities of using diffusion-weighted MRI (DW-MRI), by constructing the maps of measured diffusion coefficients (ICD) and ...
V. A. Byval’tsev, I. A. Stepanov, A. I. Kichigin   +2 more
doaj   +1 more source