Results 101 to 110 of about 364,617 (346)

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Limitations of apparent diffusion coefficient‐based models in characterizing non‐gaussian diffusion [PDF]

Magnetic Resonance in Medicine, 2005
AbstractDiffusion in complex heterogeneous structures, for example, the neural fiber system, is non‐gaussian. Recently, several methods have been introduced to address the issue of non‐gaussian diffusion in multifiber systems. Some are based on apparent diffusion coefficient (ADC) analysis; and some are based onq‐space analysis.
Chunlei, Liu, Roland, Bammer, Michael E, Moseley   +2 more
openaire   +2 more sources

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Intercentre reproducibility of cardiac apparent diffusion coefficient and fractional anisotropy in healthy volunteers

, 2014
BACKGROUND: Diffusion tensor cardiac magnetic resonance (DT-CMR) enables probing of the microarchitecture of the myocardium, but the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) reported in healthy volunteers have been inconsistent.
Ariga, R, Ferreira, P, Firmin, DN, McGill, L-A, Neubauer, S, Nielles-Vallespin, S, Pennell, DJ, Robson, MD, Scott, AD, Tunnicliffe, EM   +9 more
core   +1 more source

Multi‐system repeatability and reproducibility of apparent diffusion coefficient measurement using an ice‐water phantom [PDF]

, 2013
Purpose: To determine quantitative quality control procedures to evaluate technical variability in multi‐center measurements of the diffusion coefficient of water as a prerequisite to use of the biomarker apparent diffusion coefficient (ADC) in multi ...
Bammer, Chenevert, Chenevert, Colagrande, Collins, Delakis, Galban, Hamstra, Holz, Krynicki, Matsuya, Meier, Mulkern, Ogura, Padhani, Riches, Saritas, Sasaki, Simpson, Spees, Tiepel, Tofts, Zhu   +22 more
core   +2 more sources

Is Apparent Diffusion Coefficient Established as an Imaging Biomarker for Stereotactic Body Radiation Therapy Assessment in Hepatocellular Carcinoma? [PDF]

, 2023
Yue Cao, Kyle C. Cuneo, Joseph Evans, Randall K. Ten Haken, Daniel T. Chang, Theodore S. Lawrence   +5 more
openalex   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Variations in apparent diffusion coefficient values following chemotherapy in pediatric neuroblastoma

Diagnostic and Interventional Radiology, 2015
PURPOSEIn children the assessment of solid tumors’ response to chemotherapy is based primarily on size reduction, which can be unreliable and a late marker, in the presence of necrosis.
Senay Demir, Naime Altinkaya, Nazim Emrah Kocer, Ayse Erbay, Pelin Oguzkurt   +4 more
doaj   +1 more source

Dust settling in local simulations of turbulent protoplanetary disks

, 2006
In this paper, we study the effect of MHD turbulence on the dynamics of dust particles in protoplanetary disks. We vary the size of the particles and relate the dust evolution to the turbulent velocity fluctuations.
Fromang, S., Papaloizou, J.
core   +1 more source

Reducing variability in along-tract analysis with diffusion profile realignment [PDF]

, 2018
Diffusion weighted MRI (dMRI) provides a non invasive virtual reconstruction of the brain's white matter structures through tractography. Analyzing dMRI measures along the trajectory of white matter bundles can provide a more specific investigation than ...
Chamberland, Maxime, Leemans, Alexander, St-Jean, Samuel, Viergever, Max A.   +3 more
core   +5 more sources