Results 51 to 60 of about 267,120 (219)

Rocket‐Inspired Sequentially Targeted Nanotherapeutics for Mitochondrial Regulation and Inflammatory Reprogramming in Ischemic Stroke

Advanced Science, EarlyView.
A novel neutrophil‐hitchhiking, rocket‐inspired nanoplatform is developed to cross the blood‐brain barrier for sequential, spatiotemporal drug delivery. By responsive surface transformation in the ischemic penumbra, it precisely targets mitochondria to suppress Drp1‐mediated fission.
He Bai, Zihao Yong, Yang Li, Qingmin Chen, Yong Liu, Xiaomeng Guo, Fukai Li, Shicheng Tang, Zhuo Yang, Yufei Zhang, Ruwei Jie, Xiaohong Lv, Huacheng Wang, Chunming Huang, Liwei Xie, Jianqi Xiao, Qingchun Mu, Longguang Tang   +17 more
wiley   +1 more source

A magnetic resonance imaging and gut flora-based study of intake desire in overweight/obese type 2 diabetes mellitus patients

Frontiers in Neuroscience
BackgroundAbnormal regulation of food intake in overweight/obese type 2 diabetes mellitus (T2DM) patients is an important cause of energy intake imbalance, and studies have demonstrated that the “gut-brain axis” is involved in a wide range of metabolic ...
Mingxuan Gao, Liya Gong, Yanmei Zeng, Dongling Li, Junyan Wen, Ying Guo, Zhujia Li, Jingwen Luo, Chunling Chen, Ge Wen   +9 more
doaj   +1 more source

Dual‐Organelle Secretome Conjugation and Organ‐Uptake Tracking (DuO‐SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins

Advanced Science, EarlyView.
A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang, Rui Qian, Jiaxing Song, Xingqi Meng, Jin Young Kim, Kwok On Lai, Li Wang, Liang Zhang   +7 more
wiley   +1 more source

Effectiveness of an innovative oral hygiene product in patients with obesity and type 2 diabetes mellitus in regulating appetite and food preferences

Consilium Medicum
Background. Diabetes mellitus (DM) and obesity are diseases that lead to systemic complications that shorten life expectancy and reduce quality of life. Treatment and control of these diseases can reduce the risk of complications.
Fatima K. Dzgoeva, Elena A. Karton, Irina G. Ostrovskaya, Ekaterina A. Shestakova, Anastasiia V. Anokhina, Marina V. Shestakova   +5 more
doaj   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

Appetite and dietary intake endpoints in cancer cachexia clinical trials: Systematic Review 2 of the cachexia endpoints series

Journal of Cachexia, Sarcopenia and Muscle
There is no consensus on the optimal endpoint(s) in cancer cachexia trials. Endpoint variation is an obstacle when comparing interventions and their clinical value.
Ola Magne Vagnildhaug, Trude R. Balstad, Inger Ottestad, Asta Bye, Christine Greil, Jann Arends, Vickie Baracos, Leo R. Brown, Olav F. Dajani, Ross D. Dolan, Marie Fallon, Eilidh Fraser, Aleksandra Grzyb, Marianne J. Hjermstad, Gunnhild Jakobsen, Stein Kaasa, James McDonald, Iain Philips, Judith Sayers, Melanie R. Simpson, Mariana S. Sousa, Richard J.E. Skipworth, Barry J.A. Laird, Tora S. Solheim, the Cancer Cachexia Endpoints Working Group   +24 more
doaj   +1 more source

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang   +21 more
wiley   +1 more source

Estimation of Import Demand Functions of Two Key Food and Feed Commodities (Corn and Soybean) for India

Agribusiness, EarlyView.
ABSTRACT The derived demand for the increased demand for meat and dairy products is clearly observed in the fast‐paced growth of the Indian feed industry and its increased demand for agricultural commodities (e.g., corn, soybean, rice, wheat, broken rice, millet, etc.) as feed ingredients.
Dwiti Baruah Thapa, Sanjib Bhuyan, Kishor Goswami   +2 more
wiley   +1 more source

Return‐To‐Work and Working Status After Surgery for Gastric and Esophageal Cancer: A Prospective Observational Study

Annals of Gastroenterological Surgery, EarlyView.
In this multicenter prospective study of 158 working‐age patients undergoing curative‐intent surgery for gastric or esophageal cancer, 78.5% were working at 18 months. Postoperative appetite loss, financial difficulties, and ≥ 10% weight loss at 6 months were associated with non‐working status.
Kentaro Goto, Shigeo Hisamori, Kohei Ueno, Hiroyasu Abe, Ryosuke Okamura, Hisahiro Hosogi, Yoshito Yamashita, Dai Manaka, Hiroaki Hata, Tatsuto Nishigori, Sanae Nakajima, Michihiro Yamamoto, Koichi Kinoshita, Shintaro Okumura, Masazumi Sakaguchi, Shigeru Tsunoda, Yu Sakagami, Koya Hida, Kazutaka Obama   +18 more
wiley   +1 more source

AI Dependence as a Longitudinal Governance Problem

AI &Innovation, EarlyView.
ABSTRACT Artificial intelligence governance typically focuses on whether people rely on AI appropriately during individual decisions. This Perspective addresses a different question: whether repeated AI use changes the capabilities and alternatives available to users and organisations over time.
Yiran Du
wiley   +1 more source