Results 111 to 120 of about 2,123,628 (287)

Supermodular comparison of dependence models and multivariate processes, with applications

, 2015
The supermodular order is a well-known tool to compare the intrinsic degree of dependence between random vectors or multivariate processes. In this note we describe a general framework for the supermodular comparisons of models incorporating individual and common factors.
Frostig, E., PELLEREY, FRANCO
openaire   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Generative active learning across polymer architectures and solvophobicities for targeted rheological behavior

npj Computational Materials
Modifying solution viscosity is a key functional application of polymers, yet the interplay of molecular chemistry, polymer architecture, and intermolecular interactions makes tailoring precise rheological responses challenging.
Shengli Jiang, Michael A. Webb
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Prediction of Silicon Content in Blast Furnace Hot Metal Using Partial Least Squares (PLS)

, 2005
Multivariate modeling has gained popularity in several process industries, especially in the petrochemical sector. The Partial Least Square (PLS) is one of the various multivariate techniques where the relationship between multiple Y (responses) and ...
T. Bhattacharya
semanticscholar   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A multiscale model for collagen alignment in wound healing [PDF]

, 2005
It is thought that collagen alignment plays a significant part in scar tissue formation during dermal wound healing. We present a multiscale model for collagen deposition and alignment during this process. We consider fibroblasts as discrete units moving
Dallon, J. C., Maini, P. K., Sherratt, J. A.   +2 more
core   +1 more source

Physical Pictures of Transport in Heterogeneous Media: Advection-Dispersion, Random Walk and Fractional Derivative Formulations

, 2002
The basic conceptual picture and theoretical basis for development of transport equations in porous media are examined. The general form of the governing equations is derived for conservative chemical transport in heterogeneous geological formations, for
Anderson, Bear, Berkowitz, Berkowitz, Berkowitz, Berkowitz, Berkowitz, Berkowitz, Bouchaud, Brian Berkowitz, Chandrasekhar, Compte, Compte, Compte, Compte, Cushman, Dagan, Deng, Eggleston, Feehley, Garabedian, Gelhar, Glimm, Gnedenko, Haggerty, Harvey, Harvey Scher, Hatano, Hilfer, Jespersen, Joseph Klafter, Kenkre, Kinzelbach, Klafter, Klafter, Klafter, Koltermann, Kosakowski, Labolle, Labolle, Li, Lévy, Lévy, Mantegna, Mantegna, Margolin, Margolin, Matheron, Metzler, Metzler, Metzler, Metzler, Neuman, Oldham, Oppenheim, Ralf Metzler, Rubin, Samko, Scheidegger, Scheidegger, Scher, Scher, Scher, Shlesinger, Shlesinger, Silliman, Sposito, Zhang, Zumofen   +68 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source