Results 81 to 90 of about 2,123,628 (287)

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Linking Cellular and Mechanical Processes in Articular Cartilage Lesion Formation: A Mathematical Model [PDF]

, 2016
A severe application of stress on articular cartilage can initiate a cascade of biochemical reactions that can lead to the development of osteoarthritis.
Ayati, Bruce P., Brouillette, Marc J., Kapitanov, Georgi I., Martin, James A., Wang, Xiayi   +4 more
core   +3 more sources

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Sample Size Requirements of a Pharmaceutical Material Library: A Case in Predicting Direct Compression Tablet Tensile Strength by Latent Variable Modeling

Pharmaceutics
The material library is an emerging, new data-driven approach for developing pharmaceutical process models. How many materials or samples should be involved in a particular application scenario is unclear, and the impact of sample size on process ...
Junjie Cao, Haoran Shen, Shuying Zhao, Xiao Ma, Liping Chen, Shengyun Dai, Bing Xu, Yanjiang Qiao   +7 more
doaj   +1 more source

Waveguide physical modeling of vocal tract acoustics: flexible formant bandwidth control from increased model dimensionality [PDF]

, 2006
Digital waveguide physical modeling is often used as an efficient representation of acoustical resonators such as the human vocal tract. Building on the basic one-dimensional (1-D) Kelly-Lochbaum tract model, various speech synthesis techniques ...
Howard, D M, Mullen, J, Murphy, D T
core   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Coastal Tropical Convection in a Stochastic Modeling Framework

, 2017
Recent research has suggested that the overall dependence of convection near coasts on large-scale atmospheric conditions is weaker than over the open ocean or inland areas. This is due to the fact that in coastal regions convection is often supported by
Ajayamohan, Arakawa, Arakawa, Arritt, Bergemann, Bergemann, Birch, Borne, Boualem Khouider, Bretherton, Christian Jakob, Davies, Deng, Deng, Geotis, Gianotti, Goswami, Gregory, Haklander, Haurwitz, Hill, Hohenegger, Holland, Hottovy, Ichikawa, Jiang, Johnson, Joyce, Keenan, Khouider, Khouider, Kondo, Kousky, La Chevrotière, La Chevrotière, Mapes, Mapes, Martin Bergemann, Matsumoto, McPherson, Mori, Neale, Nguyen, Ohsawa, Oliphant, Peatman, Peters, Peters, Pollett, Pope, Qian, Qian, Randall, Rauniyar, Rotunno, Saltelli, Saltelli, Simpson, Simpson, Skinner, Slingo, Sobol, Suhas, Tan, Tiedtke, Tiedtke, Williams, Wolfram, Yang, Zhuo   +69 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Upper Limb Orthoses: Integrating Topology Optimization and 3D Printing for Custom Fit and Function

Applied Sciences
Customized wrist splints, particularly for upper extremity orthoses like wrist support braces, are commonly used across numerous clinical scenarios. However, the traditional process for producing personalized wrist splints is largely manual and highly ...
Stefanos Voulgaris, Charoula Kousiatza, George Kazakis, Konstantinos-Iason Ypsilantis, Dimitrios Galanis, Chara Ch. Mitropoulou, Maria Gkara, Stelios K. Georgantzinos, Konstantinos Soultanis, Nikos D. Lagaros   +9 more
doaj   +1 more source

Ablative Laser Structuring for Stretchable Multilayer and Multi-Material Electronics and Sensor Systems

Proceedings, 2020
Conventional machining and shaping processes for polymers and elastomers such as injection molding exhibit significant disadvantages, as specific tools have to be manufactured, the method of machining is highly dependent on the material properties, and ...
Simon P. Stier, Holger Böse
doaj   +1 more source