Results 51 to 60 of about 1,505,434 (263)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
A traffic light control method based on multi-agent deep reinforcement learning algorithm
Scientific Reports, 2023 Intelligent traffic light control (ITLC) algorithms are very efficient for relieving traffic congestion. Recently, many decentralized multi-agent traffic light control algorithms are proposed.
Dongjiang Liu, Leixiao Li
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Aplikasi Piranti Lunak Penganalisis Sintaksis Kalimat Bahasa Indonesia
ComTech, 2011 Indonesian has a vast variety in structures and sentence types that brings about difficulty in using the language correctly and accurately. This research aims for producing a software application for syntax analysis and error checking for Indonesian ...
Sablin Yusuf
doaj +1 more source
Significant wave height forecasting using WRF-CLSF model in Taiwan strait
Engineering Applications of Computational Fluid Mechanics, 2021 Short-term hourly reliable prediction of significant wave height is an important research topic in coastal engineering. Many researchers have carried out in-depth studies in many ocean regions.
Jinshan Ma +4 more
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Статистика и экономика, 2016 The article presents a systematic analysis of the problems solved by different classes of modern application software for implementation of the principles of a total quality management.
Nikolai D. Koryagin
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
A Community Detection Algorithm for Heterogeneous Information Networks
IEEE Access, 2020 With the fast development of Internet, many fields have accumulated great amount of data. And plenty of them are organized in heterogeneous information network (HIN), so analyzing HIN efficiently is very necessary.
Dongjiang Liu, Leixiao Li, Zhiqiang Ma
doaj +1 more source