Results 61 to 70 of about 4,740,911 (292)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Significant wave height forecasting using WRF-CLSF model in Taiwan strait
Engineering Applications of Computational Fluid Mechanics, 2021 Short-term hourly reliable prediction of significant wave height is an important research topic in coastal engineering. Many researchers have carried out in-depth studies in many ocean regions.
Jinshan Ma +4 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Aplikasi Piranti Lunak Penganalisis Sintaksis Kalimat Bahasa Indonesia
ComTech, 2011 Indonesian has a vast variety in structures and sentence types that brings about difficulty in using the language correctly and accurately. This research aims for producing a software application for syntax analysis and error checking for Indonesian ...
Sablin Yusuf
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Статистика и экономика, 2016 The article presents a systematic analysis of the problems solved by different classes of modern application software for implementation of the principles of a total quality management.
Nikolai D. Koryagin
doaj +1 more source
Ontology-based domain modelling for consistent content change management [PDF]
, 2010 Ontology-based modelling of multi-formatted software application content is a challenging area in content management. When the number of software content unit is huge and in continuous process of change, content change management is important.
Abgaz, Yalemisew +2 more
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
SAND ML: Software para el diagnóstico y control de información de máquinas eléctricas rotatorias
Revista Científica de Ingeniería Energética, 2011 SAND ML es un software de aplicación que automatiza los procesos asociados a: inventarios yprocesamiento de la información según lo establecido en las normas y procedimientos para el diagnósticode máquinas elé ...
Santiago A Dorrbercker Drake +3 more
doaj
A Community Detection Algorithm for Heterogeneous Information Networks
IEEE Access, 2020 With the fast development of Internet, many fields have accumulated great amount of data. And plenty of them are organized in heterogeneous information network (HIN), so analyzing HIN efficiently is very necessary.
Dongjiang Liu, Leixiao Li, Zhiqiang Ma
doaj +1 more source