Results 131 to 140 of about 15,603,096 (267)

Information Technology Newsletter June 2005

open access: yes, 2005
University of Minnesota: Office of Information Technology. (2005). Information Technology Newsletter June 2005.
University of Minnesota: Office of Information Technology
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Information Technology Newsletter December 2004

open access: yes, 2004
University of Minnesota: Office of Information Technology. (2004). Information Technology Newsletter December 2004.
University of Minnesota: Office of Information Technology
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Information Technology Newsletter April 2005

open access: yes, 2005
University of Minnesota: Office of Information Technology. (2005). Information Technology Newsletter April 2005.
University of Minnesota: Office of Information Technology
core  

Análise da distribuição volumétrica de pontas de pulverização hidráulicas de jato plano Volumetric distribution analysis of flat fan hydraulic spray nozzles

open access: yesRevista de Ciências Agrárias, 2008
O padrão de deposição volumétrica é um parâmetro muito importante para a seleção da ponta de pulverização adequada para cada aplicação de agrotóxico. Assim, este trabalho teve como objetivo analisar a distribuição volumétrica de pontas de pulverização ...
João Paulo Arantes Rodrigues da Cunha
doaj  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Information Technology Newsletter September 2005

open access: yes, 2005
University of Minnesota: Office of Information Technology. (2005). Information Technology Newsletter September 2005.
University of Minnesota: Office of Information Technology
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Information Technology Newsletter November 2005

open access: yes, 2005
University of Minnesota: Office of Information Technology. (2005). Information Technology Newsletter November 2005.
University of Minnesota: Office of Information Technology
core  

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