Results 61 to 70 of about 878,093 (282)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Fault-Tolerant Partition Resolvability of Cyclic Networks
Journal of Mathematics, 2021 Graph invariants provide an amazing tool to analyze the abstract structures of networks. The interaction and interconnection between devices, sensors, and service providers have opened the door for an eruption of mobile over the web applications ...
Kamran Azhar +3 more
doaj +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
An Application of Graph Theory to Additive Number Theory
European Journal of Combinatorics, 1985 It is proved that, if \({\mathfrak A ...
Alon, Noga, Erdös, P.
openaire +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
The development of e-learning applications solving problems from graph theory
Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2013 Authors are in long term developing e-learning supports for some parts of Operation Research course. The original purpose was to prepare e-learning supports for students of FBE Mendelu, mainly for part-time form students, who have subscribed Economic ...
Pavel Kolman, Petr Zach, Josef Holoubek
doaj +1 more source
On applications of bipartite graph associated with algebraic structures
Open Mathematics, 2020 The latest developments in algebra and graph theory allow us to ask a natural question, what is the application in real world of this graph associated with some mathematical system? Groups can be used to construct new non-associative algebraic structures,
Zhang Xiujun +3 more
doaj +1 more source
A visual representation of part-whole relationships in BFO-conformant ontologies [PDF]
, 2017 In the visual representation of ontologies, in particular of part-whole relationships, it is customary to use graph theory as the representational background.
de Oliveira, Jose M. Parente +1 more
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Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source