Results 61 to 70 of about 54,702 (261)
MathematicsThe incidence of edges on vertices is a cornerstone of graph theory, with profound implications for various graph properties and applications. Understanding degree distributions and their implications is crucial for analyzing and modeling real-world ...
A. R. Nagalakshmi +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Topology Index of a Zero Divisor Graph on a Ring of Integers Modulo Prime Power Order
Contemporary Mathematics and Applications (ConMathA)In chemistry, graph theory has been widely utilized to address molecular problems, with numerous applications in graph theory and ring theory within this field.
Didit Satriawan +4 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Graph-Theoretic Problems and Their New Applications
Mathematics, 2020 Graph theory is an important area of Applied Mathematics with a broad spectrum of applications in many fields [...]
Frank Werner
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Graph theory and their application
A framework is offered here after reviewing many works based on graph theory. Part one of this chapter surveys the relevant literature on the subject of communication networks and graph theory, while part two offers’ instances to demonstrate the connection between the two.
Gunamma Prasadarao, Dr. Manish KR Singh
openaire +2 more sources
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Applications of graph theory to the analysis of fNIRS data in hyperscanning paradigms. [PDF]
Front Comput Neurosci, 2022 Oku AYA +5 more
europepmc +1 more source