Results 181 to 190 of about 41,081 (281)

EIF5A Couples Translational Control With Transcriptional Reprogramming Through Chromocenter Reorganization During Spermiogenesis

Advanced Science, Volume 13, Issue 9, 13 February 2026.
The translation factor Eukaryotic translation initiation factor 5A (eIF5A) is essential for male fertility in mice. It supports the translation of proteins crucial for heterochromatin organization and acrosome formation. eIF5A deficiency disrupts chromocenter integrity, increases chromatin accessibility, and causes transcriptional dysregulation ...
Yuling Cai, Tongtong Li, Qian Fang, Ziyou Bao, Feng Kong, Huitao Qi, Hanzhen Li, Mingyu Zhang, Wei Wang, Yongxia Guan, Wenbo Liu, Xiangfeng Chen, Zi‐Jiang Chen, Xiaohua Jiang, Xin Wang, Hongbin Liu   +15 more
wiley   +1 more source

Exact Expressions for Kullback-Leibler Divergence for Univariate Distributions. [PDF]

Entropy (Basel)
Nawa V, Nadarajah S.
europepmc   +1 more source

Inferring Gene Regulatory Networks From Single‐Cell RNA Sequencing Data by Dual‐Role Graph Contrastive Learning

Advanced Science, Volume 13, Issue 9, 13 February 2026.
RegGAIN is a novel and powerful deep learning framework for inferring gene regulatory networks (GRNs) from single‐cell RNA sequencing data. By integrating self‐supervised contrastive learning with dual‐role gene representations, it consistently outperforms existing methods in both accuracy and robustness.
Qiyuan Guan, Jiating Yu, Jieyi Pan, Fan Yuan, Jiadong Ji, Rusong Zhao, Zhi‐Ping Liu, Bingqiang Liu, Ling‐Yun Wu, Duanchen Sun   +9 more
wiley   +1 more source

CooccurrenceAffinity: An R package for computing a novel metric of affinity in co-occurrence data that corrects for pervasive errors in traditional indices. [PDF]

PLoS One
Mainali KP, Slud E.
europepmc   +1 more source

Transcriptome Differentiation of Wild and Hatchery‐Reared Gibelion catla Fish in Bangladesh

Aquaculture, Fish and Fisheries, Volume 6, Issue 1, February 2026.
ABSTRACT Transcriptome differences between wild and hatchery‐reared Gibelion catla collected from Halda (HL) and Padma River (PD) as wild and a hatchery (HR) population in Bangladesh were identified in this study. A total of 6780 differentially expressed genes (DEGs) in HL compared to HR indicated significant variations in gene expression consistent ...
Shumaya Shafrin, Md. Alamgir Kabir, Md. Golam Rabbane   +2 more
wiley   +1 more source

Whole-genome profiling of age- and sex-associated DNA methylation signatures in human plasma cell-free DNA. [PDF]

Commun Med (Lond)
Chen W, Xu J, Zeng G, Ou R, Yang C, Xu C, Wang Y, Wang X, Li Q, Zhao C, Zhou W, Lin Y, Pang W, Zhang H, Yin J, Zhang Y, Jin X.   +16 more
europepmc   +1 more source

Multiomic single nuclei profiling the mouse hippocampus reveals that ACSS2 confers neuronal resilience to tauopathy

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Epigenomic dysregulation contributes to Alzheimer's disease (AD) and related tauopathies. Acetyl‐CoA synthetase 2 (ACSS2), a nuclear‐localized metabolic enzyme in neurons, supports histone acetylation and learning‐related gene expression.
Gabor Egervari, Desi C. Alexander, Hua Huang, Greg Donahue, Connor Hogan, Mariel Mendoza, Hong Xu, Virginia Lee, Ben Garcia, Nancy Bonini, Shelley Berger   +10 more
wiley   +1 more source

Generation of 12 <i>major-terms</i> for interpretating human cellular processes. [PDF]

Comput Struct Biotechnol J
Liu Y, Liu R, Hu J, Wang Y, Zhang J.
europepmc   +1 more source

Single‐cell analysis reveals neuroprotective histone deacetylase inhibitor pathways

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) involves β‐amyloid (Aβ) accumulation, tau pathology, and neuroinflammation, driving cognitive decline. Despite extensive research, disease‐modifying therapies remain elusive. We integrated single‐cell RNA sequencing (scRNA‐seq), spatial transcriptomics, and in vitro validation to identify repurposable ...
Madeline Peyton, Nur Jury‐Garfe, Jiahui Liu, Caleb Beimfohr, Chitra Sunil, Steven Brooks, Pengyue Zhang, Sean D. McCabe, Timothy I. Richardson, Kun Huang, Cristian A. Lasagna‐Reeves, Jie Zhang, Travis S. Johnson   +12 more
wiley   +1 more source

Better understanding the phenotypic effects of drugs through shared targets in genetic disease networks. [PDF]

Front Pharmacol
Díaz-Santiago E, Moya-García AA, Pérez-García J, Yahyaoui R, Orengo C, Pazos F, Perkins JR, Ranea JAG.   +7 more
europepmc   +1 more source