Results 181 to 190 of about 41,148 (275)

Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma

Advanced Science, Volume 13, Issue 25, 4 May 2026.
This study identifies mutation‐intolerant genes (MIGs), which are mutationally constrained in tumors despite normal‐tissue variability. Using miDriver, the authors pinpoint MIGs essential for tumor‐intrinsic fitness and immune evasion. Focusing on CHEK1, they show it drives tumor fitness and sculpts an immunosuppressive niche via the MIF–CD74 axis ...
Tao Wang, Hongyu Zhao, Xiaojie Sun, Yuqi Ding, Zhipeng Zhu, Xiaotong Yu, Rongyi Zhu, Dan Wang, Kailong Li, Yang Liu, Li‐Bin Wang, Xiaolu Zhao, Baojun Suo, Hongsen Bi, Peipei Zhang, Tong Liu, Fengbiao Mao   +16 more
wiley   +1 more source

A quadratic transformation for a special confluent Heun function. [PDF]

Heliyon
Ishkhanyan AM.
europepmc   +1 more source

Single‐cell transcriptomic analysis reveals APOE genotype‐dependent sex differences in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) is the most common form of dementia, with approximately two‐thirds of AD patients being female. Basic and clinical research studies provide strong evidence that sex‐specific differences contribute to AD complexity.
Gefei Yu, Abigail Thorpe, Qi Zeng, Erming Wang, Alison Goate, Dongming Cai, Minghui Wang, Bin Zhang   +7 more
wiley   +1 more source

Insights into glandular trichome biology from analysis of organ-specific gene expression programmes in cannabis, hop and tomato. [PDF]

Plant J
Tamiru-Oli M, Hurgobin B, Berkowitz O, Yin L, Jost R, Gvaramiya S, Welling M, Doblin MS, Bacic A, Whelan J, Lewsey MG.   +10 more
europepmc   +1 more source

Full‐Length Transcriptome Profiles Reveal the Molecular Function of Oncogene HNRNPA2B1 in Triple‐Negative Breast Cancer

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Triple negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer with the worst prognosis. Heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), a member of the RNA‐binding protein (RBP) hnRNPs family, is aberrantly expressed in various human cancers, serving as a marker of poor prognosis and acting as an oncogene ...
Lina Yi, Yongtao Li, Jianghua Ou
wiley   +1 more source

Some new applications of the fractional integral and four-parameter Mittag-Leffler function. [PDF]

PLoS One
Abubaker AA, Matarneh K, B Al-Shaikh S, Khan MF.   +3 more
europepmc   +1 more source

Safety and Feasibility of a CT‐Based Pathway for Left Atrial Appendage Assessment Prior to Inpatient Cardioversion: A Single‐Center Experience

Clinical Cardiology, Volume 49, Issue 5, May 2026.
An alternative for TEE? Cardiac CT is a practical alternative for ruling out LA/LAA thrombi in hospitalized patients who need cardioversion. ABSTRACT Background Transesophageal echocardiography (TEE) for left atrial appendage (LAA) thrombus exclusion before cardioversion faces logistical barriers including limited availability, patient intolerance, and
Ariel Furer, Maxim Perelman, Yafim Brodov, Orly Goitein, Sagit Ben Zikri, Rafael Kuperstein, Edward Itelman, Elad Maor, Eyal Nof, Roy Beinart, Shlomi Matetzky, Roy Beigel   +11 more
wiley   +1 more source

Proteomic mapping of Rosa damascena nanovesicles reveals plastid mitochondrial metabolic convergence and antimicrobial peptides. [PDF]

Plant Signal Behav
Brahadeeswaran S, Tamizhselvi R.
europepmc   +1 more source

Oncogenic driver and therapeutic target: Prolactin signalling axis in retroperitoneal sarcoma

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
Retroperitoneal sarcoma cells can secrete prolactin into the bloodstream, inducing hyperprolactinaemia, which subsequently triggers metabolic reprogramming, such as glucose metabolism. SOX4 can function as a transcription factor that facilitates PRL transcription.
Fu'an Xie, Lingwei Gu, Kunrong Yang, Shuai Wang, Mengmeng Xiao, Guangting Yan, Quan Zhang, Rubing Liang, Aobo Zhuang, Zhe Xi, Yujia Niu, Yanhua Chen, Xiaogang Xia, Linlin Qu, Bin Zhao, Weibing Li, Ting Wu, Chundong Yu, Chenghua Luo, Houzhao Wang, Lanlan Lian, Wengang Li   +21 more
wiley   +1 more source

Exact analytical solutions of the Bloch equation for the hyperbolic-secant and chirp pulses. [PDF]

Magn Reson Med
Smith RHB, Garwood D, Garwood M.
europepmc   +1 more source