Results 191 to 200 of about 41,081 (281)

Epstein–Barr Virus, Lower Vitamin D, Low Sun Exposure, and HLA‐DRB1*1501 Risk Variant Share Common Epigenetic Pathways Leading to Multiple Sclerosis Onset

Annals of Neurology, Volume 99, Issue 2, Page 341-355, February 2026.
[Color figure can be viewed at www.annalsofneurology.org] Objectives Multiple sclerosis (MS) onset risk factors include Epstein–Barr virus (EBV) indices (including host response), lower serum 25‐vitamin D (25(OH)D) levels, low sun exposure, and HLA‐DRB1*1501. The underlying molecular mechanisms are unclear.
Steve Simpson‐Yap, Ellen Morwitch, Samuel A. Tanner, Sarah M. Thomson, Alex Eisner, Rod A. Lea, Trevor J. Kilpatrick, Jeannette Lechner‐Scott, Rodney J. Scott, Alexandre Xavier, Vicki E. Maltby, Robyn M. Lucas, Bruce V. Taylor, Brett A. Lidbury, Simon A. Broadley, Ingrid van der Mei, Mehari Woldemariam Merid, Boris Novakovic, Richard Saffery, Anna Karin Hedström, Pernilla Stridh, Tomas Olsson, Maja Jagodic, Lars Alfredsson, Anne‐Louise Ponsonby, for the Ausimmune Investigator Group, Caron Chapman, Alan Coulthard, Keith Dear, Terry Dwyer, Trevor Kilpatrick, Robyn Lucas, Tony McMichael, Anne‐Louise Ponsonby, Bruce Taylor, Patricia Valery, Ingrid van der Mei, David Williams   +37 more
wiley   +1 more source

Exact Expressions for Kullback-Leibler Divergence for Multivariate and Matrix-Variate Distributions. [PDF]

Entropy (Basel)
Nawa V, Nadarajah S.
europepmc   +1 more source

Identification of Glioma Phenotypic Subtypes From Multimodal MRI Data Using Hierarchical Multi‐Kernel Learning

Cancer Medicine, Volume 15, Issue 2, February 2026.
Our study identified glioma phenotypic subtypes based on T1CE and T2FLAIR radiomic features, along with associated pathway activities, providing real‐time insights into tumor dynamics to guide preoperative clinical decision‐making and improve patient management.
Junyu Yan, Min Hao, Tong Wang, Qi Yang, Congcong Jia, Wenju Niu, Yan Tan, Hui Zhang, Hongyan Cao, Guoqiang Yang   +9 more
wiley   +1 more source

DENetwork unveils non-differentially expressed genes with functional relevance across conditions through information flow perturbation. [PDF]

Nucleic Acids Res
Zhao B, Su TY, Wang J, Islam QS, Song K, Huang SK, Allez M, Fonseca GJ, Baglole CJ, Ding J.   +9 more
europepmc   +1 more source

Single‐cell analysis reveals cytotoxic and memory CD8+ T cells associated with prolonged survival in relapsed/refractory leukaemia patients after haplo+cord haematopoietic stem cell transplantation

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
1. Haplo+cord HSCT yields superior survival compared with single cord HSCT in patients with R/R leukaemia. 2. Single‐cell RNA‐seq revealed a functionally critical CD8⁺ T cell population, with cytotoxic and memory phenotypes, which expands after haplo+cord HSCT and tracks with prolonged survival. 3. Multi‐omics profiling at single‐cell resolution showed
Hua Li, Zheyang Zhang, Ming Zhu, Xiaofan Li, Jinxian Dai, Ping Chen, Fei Chen, Xianling Chen, Yiding Yang, Xiaohong Yuan, Ronghan Tang, Zhijuan Zhu, Hongli Lin, Ting Lin, Mengsha Tong, Tao Chen, Yuanzhong Chen, Jialiang Huang, Nainong Li   +18 more
wiley   +1 more source

An unbiased whole-genome open reading frame overexpression screen identifies B3GALT2, a novel inducer of cellular ASO activity. [PDF]

Mol Ther Nucleic Acids
Hesselmann J, Hager C, Malong L, Fortin JP, Schmucki R, Lau T, Martin S, Costa M, Modrusan Z, Haley B, Roudnicky F.   +10 more
europepmc   +1 more source

High‐throughput single‐cell DNA methylation and chromatin accessibility co‐profiling with SpliCOOL‐seq

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
SpliCOOL‐seq achieves high‐throughput single‐cell co‐profiling of DNA methylation and chromatin accessibility. DNMT inhibitors caused cancer cell demethylation with divergent patterns. SpliCOOL‐seq enables the discovery of genes related to LUAD tumorigenesis. Ageing and LUAD tumorigenesis may share similar epigenetic alterations.
Qingmei Shen, Enze Deng, Ling Luo, Jingna Zhang, Qifeng Yang, Dan Su, Xiaoying Fan   +6 more
wiley   +1 more source

The AGM of Gauss, Ramanujan's corresponding theory, and spectral bounds of self-adjoint operators. [PDF]

Mon Hefte Math
Faulhuber M, Gumber A, Shafkulovska I.
europepmc   +1 more source

Molecular and Transcriptional Signatures of Gray Matter Volume Alterations Associated With Depressive Symptoms in Mild Cognitive Impairment

Human Brain Mapping, Volume 47, Issue 2, February 1, 2026.
Morphological alterations related to depressive symptoms in mild cognitive impairment were primarily involved in emotion and affective processing, showing strong correspondence with serotonergic, dopaminergic, and GABAergic systems and enrichment of genes associated with synaptic function and excitatory neurons.
Hu Xu, Yang Li, Chensi Li, Fenglin Xu, Yun Liu, Kehan Yan, Shiyi Chen, Wenxiu Song, Yifeng Luo, Yuefeng Li   +9 more
wiley   +1 more source

Periodic structures of solitons and shock wave solutions in the fractional nonlinear Shynaray-IIA equation via a generalized analytical method. [PDF]

Sci Rep
Iqbal M, Khan MI, Alrashdi HD, Algethamie R, Alomari FAH, Aljohani A, Mohammad N, Aljawi S.   +7 more
europepmc   +1 more source