Results 111 to 120 of about 6,779,987 (295)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Drama and the culture of challenge

open access: yes, 2019
Rachel Jacobs shares her study on student engagement within the Drama classroom and their ability to deal with challenges. She provides insight about the challenges faced by Drama students, while drawing upon the various cultural frames that feed into ...
Jacobs, Rachael (R18862)
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Challenges of drama performance assessment

open access: yes, 2016
As with any subject area, Drama’s inclusion in the secondary curriculum must conform to curriculum policies and procedures, including those related to assessment and certification. In Drama, students’ creative work is assessed formatively and summatively
Jacobs, Rachael (R18862)
core  

Dramatic Encounters Artistry, Community and Scholarship in Drama Teaching

open access: yes, 2020
This book provides examples of outstanding quality drama teaching and community engagement. Each chapter describes and shares work that is characterized by artistry, with creativity and the aesthetic of the art form of drama as paramount.
Stinson, Madonna
core  

Sexism: an examination of the role of the teacher in drama in education [PDF]

open access: yes, 1988
This study examines three elements: sexism, drama in education and the role of the teacher, towards increasing understanding of how sexism is reinforced.
Tate, Margaret E.
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Performance footprints across Australia : assessment in senior secondary drama

open access: yes, 2010
Australia’s state and territory systems of education inevitably lead to varying interpretations of drama education and assessment. This paper examines the various models of senior secondary Drama performance assessment across Australian states and ...
Jacobs, Rachael (R18862)
core  

Negotiating the Spaces: Relational Pedagogy and Power in Drama Teaching [PDF]

open access: yes, 2007
While there is a growing body of literature on relational pedagogy as a concept, less attention is given to the details of just how relational pedagogy manifests in classroom practice.
Aitken, Vivienne Jane   +2 more
core  

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