Results 131 to 140 of about 5,230 (250)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
, 2013 This article explores the use of applied drama as a learning medium for trainee teachers who had not previously experienced the use of drama as a pedagogic approach, in an effort to develop professional relational skills, including conflict management. A
Morrison, Morag +2 more
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Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Passion, Partnership, Power and Persistence: The Rise and Fall of a Transnational Drama Programme
, 2016 本文以一個跨國戲劇課程為個案，討論把應用劇場與戲劇教育首個 學位課程引入香港的經驗。作者檢視課程從開始至結束的十年間所 經歷的發展和考驗，討論兩所學院在協作中如何處理教與學的跨文 化議題，分析課程在香港和澳洲帶來的影響，思考這類課程之可持續 發展。通過分析本個案，作者引申更闊的思考，提出在應用劇場╱ 戲劇教育的實踐中，「跨文化議題」、「評估影響」、「可持續發 展」同樣是三個重要題目，深入探索這些題目，有助思考應用劇場 與戲劇教育在香港與其他地方的未來發展 In this article, the ...
Dunn, Julie, Chan, Phoebe Yuk-lan
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Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Dialect, drama and translation : a socio-cultural investigation into the factors influencing the choice of strategies in German-speaking Europe [PDF]
This thesis examines the translation of dialect in drama in German-speaking Europe, exploring the complex influences on the choice of strategies by practitioners.
Rissmann, Jeannette
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
This thesis explores the change that occurs through the experience of Applied Theatre and participatory drama with specific participant groups: adults with learning disabilities, and those recovering from mental illness.
Higgins, Rebecca
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source