Results 71 to 80 of about 15,813,200 (328)

Application of artificial neural networks for the prediction of interface mechanics: a study on grain boundary constitutive behavior

Advanced Modeling and Simulation in Engineering Sciences, 2020
The present work aims at the identification of the effective constitutive behavior of $$\Sigma 5$$ Σ5 aluminum grain boundaries (GB) for proportional loading by using machine learning (ML) techniques.
Mauricio Fernández, Shahed Rezaei, Jaber Rezaei Mianroodi, Felix Fritzen, Stefanie Reese   +4 more
doaj   +1 more source

Comparative study of cell mechanics methods

Nature Methods, 2018
The mechanical properties of cells influence their cellular and subcellular functions, including cell adhesion, migration, polarization, and differentiation, as well as organelle organization and trafficking inside the cytoplasm.
Pei-Hsun Wu, D. R. Aroush, A. Asnacios, Wei-Chiang Chen, M. Dokukin, Bryant L. Doss, P. Durand-Smet, A. Ekpenyong, J. Guck, N. Guz, P. Janmey, J. Lee, N. M. Moore, A. Ott, Y. Poh, R. Ros, M. Sander, I. Sokolov, Jack R. Staunton, Ning Wang, G. Whyte, D. Wirtz   +21 more
semanticscholar   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Multiscale studies on the nonlinear vibration of delaminated composite laminates–global vibration mode with micro buckles on the interfaces

Scientific Reports, 2017
This paper presents a multiscale approach to study the nonlinear vibration of fiber reinforced composite laminates containing an embedded, through-width delamination dividing the laminate into four sub-laminates.
Jianghong Xue, Fei Xia, Jun Ye, Jianwen Zhang, Shuhua Chen, Ying Xiong, Zuyuan Tan, Renhuai Liu, Hong Yuan   +8 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Reports in Applied Mechanics 2025

This is the fourth volume of the concurring series of Reports in Applied Mechanics, which is based on the outcome of the advanced project course TMPM10 in Applied Mechanics at Link¨oping University during the autumn of 2025. The course lay-up is based on
Andersson, Magnus,, Leidermark, Daniel,
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

A Formulation of Structural Design Optimization Problems for Quantum Annealing

Mathematics
We present a novel formulation of structural design optimization problems specifically tailored to be solved by qa. Structural design optimization aims to find the best, i.e., material-efficient yet high-performance, configuration of a structure. To this
Fabian Key, Lukas Freinberger
doaj   +1 more source