Results 61 to 70 of about 170,997 (257)

Tribological behaviors of stator rubber with hexagonal micro-texture and enclosed groove of bionic honeycomb structure

iScience
Summary: The model of hydrodynamic lubrication in the flow field was developed by coupling of hexagonal micro-texture and enclosed groove with a bionic honeycomb structure.
Xin-Fu Liu, Chun-Hua Liu, Guang-Xin Hou, Jiang-Yan Guo, Zhong-Xian Hao, Xiang-Zhi Shi   +5 more
doaj   +1 more source

Predictive maintenance and safety operation by device integration on the QUEST large experimental device

Heliyon, 2020
As technology has improved in recent years, it has become possible to create new valuable functions by combining various devices and sensors in a network.
Makoto Hasegawa, Kazuaki Hanada, Hiroshi Idei, Shoji Kawasaki, Takahiro Nagata, Ryuya Ikezoe, Takumi Onchi, Kengoh Kuroda, Aki Higashijima   +8 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Immunofluorescence can assess the efficacy of mTOR pathway therapeutic agent Everolimus in breast cancer models

Scientific Reports, 2019
When breast cancer patients start to exhibit resistance to hormonal therapy or chemotherapy, the mTOR inhibitor everolimus can be considered as an alternative therapeutic agent.
Chun-Ting Kuo, Chen-Lin Chen, Chih-Chi Li, Guan-Syuan Huang, Wei-Yuan Ma, Wei-Fan Hsu, Ching-Hung Lin, Yen-Shen Lu, Andrew M. Wo   +8 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Nanocardboard as a nanoscale analog of hollow sandwich plates

Nature Communications, 2018
Sandwich structures such as corrugated cardboard offer low weight and high bending stiffness, but they are difficult to produce at the nanoscale. Here, the authors combine webbing and perforation to produce alumina ‘nanocardboard’ with ultralow areal ...
Chen Lin, Samuel M. Nicaise, Drew E. Lilley, Joan Cortes, Pengcheng Jiao, Jaspreet Singh, Mohsen Azadi, Gerald G. Lopez, Meredith Metzler, Prashant K. Purohit, Igor Bargatin   +10 more
doaj   +1 more source

On the use of reduced integration in combination with discontinuous Galerkin discretization: application to volumetric and shear locking problems

Advanced Modeling and Simulation in Engineering Sciences, 2018
In the present work, the discontinuous Galerkin (DG) method is applied to linear elasticity for two-dimensional and three-dimensional settings. A locking-free element formulation based on reduced integration and physically-based hourglass stabilization ...
Hamid Reza Bayat, Stephan Wulfinghoff, Steffen Kastian, Stefanie Reese   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source