Results 81 to 90 of about 237,682 (300)

Nanocardboard as a nanoscale analog of hollow sandwich plates

Nature Communications, 2018
Sandwich structures such as corrugated cardboard offer low weight and high bending stiffness, but they are difficult to produce at the nanoscale. Here, the authors combine webbing and perforation to produce alumina ‘nanocardboard’ with ultralow areal ...
Chen Lin, Samuel M. Nicaise, Drew E. Lilley, Joan Cortes, Pengcheng Jiao, Jaspreet Singh, Mohsen Azadi, Gerald G. Lopez, Meredith Metzler, Prashant K. Purohit, Igor Bargatin   +10 more
doaj   +1 more source

On the use of reduced integration in combination with discontinuous Galerkin discretization: application to volumetric and shear locking problems

Advanced Modeling and Simulation in Engineering Sciences, 2018
In the present work, the discontinuous Galerkin (DG) method is applied to linear elasticity for two-dimensional and three-dimensional settings. A locking-free element formulation based on reduced integration and physically-based hourglass stabilization ...
Hamid Reza Bayat, Stephan Wulfinghoff, Steffen Kastian, Stefanie Reese   +3 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Friction coefficient and error test via micro-rotation mechanics model

, 2012
An air pressure-loading mode incorporated into the friction apparatus is firstly applied to coatings tribology involving large load, automation, stepless and continuous loading processes.
陈支通, 李光, 夏原
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

SDRE APPLIED TO POSITION AND VIBRATION CONTROL OF A ROBOT MANIPULATOR WITH A FLEXIBLE LINK

, 2016
This paper presents position and vibration control of a flexible robot composed of two rigid and one flexible links. Position is controlled by the current applied to the DC motor armature.
Nascimento, Claudinor Bitencourt, Lima, Jeferson Jose de, Balthazar, Jose Manoel [UNESP], Tusset, Angelo Marcelo, Janzen, Frederic Conrad, Rebello da Fonseca Brasil, Reyolando Manoel Lopes, Piccirillo, Vincius   +6 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Magneto-electro-mechanical coupling phenomena across multiple length scales : variational framework and stability analysis [PDF]

, 2019
With the rapid advances in micro-electronics and data-processing, multiscale material models can be incorporated in the development process of innovative functional materials.
Vallicotti, Daniel
core   +1 more source

Interpolation of final geometry and result fields in process parameter space

MATEC Web of Conferences, 2016
Different routes to produce a product in a bulk forming process can be described by a limited set of process parameters. The parameters determine the final geometry as well as the distribution of state variables in the final shape.
Misiun Grzegorz, Wang Chao, Geijselaers Hubert, van den Boogaard Ton   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source