Results 91 to 100 of about 6,470,544 (298)

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

FEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti, Sebastian Obermaier, Dirk J. Slotboom, Bert Poolman   +3 more
wiley   +1 more source

Targeting rapid TKI‐induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia

Molecular Oncology, EarlyView.
Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale, Li Li, J. Kyle Bruner, Melody Chou, Bao Nguyen, Jaesung Seo, Ruiqi Zhu, Mark J. Levis, Christine A. Pratilas, Donald Small   +9 more
wiley   +1 more source

Elliptic mirror finite element analysis of double drive compensated bending

He jishu, 2022
BackgroundIn order to meet the technical requirements of synchrotron radiation beamlines for related optical components, a double-drive four-point roller bending mechanism is designed.PurposeThis study aims to implement an unequal moment elliptical ...
MA Tianyu, LU Qipeng, WANG Dazhuang, PENG Zhongqi, GONG Xuepeng, SONG Yuan   +5 more
doaj   +1 more source

The PTTG1/VASP axis promotes oral squamous cell carcinoma metastasis by modulating focal adhesion and actin filaments

Molecular Oncology, EarlyView.
VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park, Sang Shin Lee, Shihyun Kim, Yeonjun Lee, Gyeonwon Park, Jung Oh Kim, Jongho Choi   +6 more
wiley   +1 more source

Optical combs and optical vortices combined for spatiotemporal manipulation of light and matter [PDF]

arXiv, 2020
In this study, we demonstrate the concept of combining optical combs with optical vortices for the first time. By combining the advantages of the both light sources, we realize an optical vortex comb technology for arbitrary spatiotemporal phase manipulation.
arxiv  

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

Molecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran, Clarence Yapp, Gregory J. Baker, Johanna Beyer, Young Hwan Chang, Allison L. Creason, Robert Krueger, Jeremy Muhlich, Nathan Heath Patterson, Kevin Sidak, Damir Sudar, Adam J. Taylor, Luke Ternes, Jakob Troidl, Xie Yubin, Artem Sokolov, Darren R. Tyson   +16 more
wiley   +1 more source

Optimization of Thermal Control Design for Aerial Reflective Opto-Mechanical Structure

Sensors
To improve the adaptability of aerial reflective opto-mechanical structures (mainly including the primary mirror and secondary mirror) to low-temperature environments, typically below −40 °C, an optimized thermal control design, which includes passive ...
Huilin Wang, Yun Zhou, Xiaocun Jiang, Xiaozhou Zuo, Ming Chen   +4 more
doaj   +1 more source

A Global Decoupling Control Algorithm for LC-DM Adaptive Optics System

IEEE Access, 2021
The liquid crystal (LC) and deformable mirror (DM) cascaded adaptive optics (AO) system can be used to effectively extend the imaging waveband of a large aperture telescope from the infrared to the visible waveband. However, to maintain the effectiveness
Yukun Wang, Xingyun Zhang, Dayu Li, Quanquan Mu, Li Xuan   +4 more
doaj   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Effect of fill-factor on the Talbot effect of diffraction gratings [PDF]

Journal of the European Optical Society-Rapid Publications, 2011
We analyze the effect of the fill factor of binary diffraction gratings on the Talbot effect under a scalar approach. We show that the location of the best-visibility planes changes with the configuration parameters of the grating, that is, the amplitude
Salgado-Remacha Francisco Javier, Sanchez-Brea Luis Miguel, Bernabeu Eusebio   +2 more
doaj   +1 more source