Results 61 to 70 of about 584,758 (318)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Deviations from early--time quasilinear behaviour for the quantum kicked rotor near the classical limit

, 2004
We present experimental measurements of the mean energy for the atom optics kicked rotor after just two kicks. The energy is found to deviate from the quasi--linear value for small kicking periods.
A. J. Lichtenberg, Mark Sadgrove, Rainer Leonhardt, Scott Parkins, Terry Mullins   +4 more
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Noise and resolution in IO interferometric sensing [PDF]

, 2007
The paper presents a general theory for sensing devices, relating noise and device parameters to resolution of modal index changes. The theory is applied to optimise the length of a few integrated optics sensing devices, being a Mac-Zehnder ...
Hoekstra, H.J.W.M., Koster, T.M., Lambeck, P.V., Uranus, H.P.   +3 more
core   +1 more source

Multiplexing of encrypted data using fractal masks

, 2012
This paper was published in OPTICS LETTERS and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: http://dx.doi.org/10.1364/OL.37.002895.
Barrera, Barrera, Dafne Amaya, Henao, Hwang, John F. Barrera, Juan A. Monsoriu, Liu, Matoba, Matoba, Monsoriu, Mosso, Myrian Tebaldi, Nomura, Néstor Bolognini, Refregier, Roberto Torroba, Situ, Tebaldi, Unnikrishnan, Walter D. Furlan   +20 more
core   +1 more source

Light Scattering of optical Components and their Imperfections: Measurement, Modelling, and System Analysis [PDF]

EPJ Web of Conferences
Light scattering in optical systems is caused by various imperfections such as surface roughness, bulk inhomogeneity, contamination, and ghost light beam paths.
Herffurth Tobias, Mühlig Christian, Munser Anne-Sophie, Schröder Sven   +3 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Self-consistent characterization of light statistics

, 2008
We demonstrate the possibility of a self-consistent characterization of the photon-number statistics of a light field by using photoemissive detectors with internal gain simply endowed with linear input/output responses. The method can be applied to both
Agliati A, Alessandra Andreoni, Alessia Allevi, Andrea Agliati, Mandel L, Maria Bondani, Raymer M   +6 more
core   +1 more source

Physical Optics Applied to Parallel-Plate Lens Antennas

IEEE Open Journal of Antennas and Propagation
The Physical Optics (PO) method is used to derive simplified expressions to compute the radiation electric fields of planar graded-index and geodesic lenses based on a parallel-plate waveguide (PPW) implementation.
Francisco Mesa, Mingzheng Chen, Pilar Castillo-Tapia, Oscar Quevedo-Teruel   +3 more
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source