Results 151 to 160 of about 6,938,619 (347)

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Optical multilayer thin film structure inverse design: From optimization to deep learning

iScience
Summary: Optical multilayer thin film structures have been widely used in numerous photonic domains and applications. The key component to enable these applications is the inverse design.
Taigao Ma, Mingqian Ma, L. Jay Guo
doaj   +1 more source

[Influences of the Corona pandemic on health-related behaviors and stresses of students]. [PDF]

Pravent Gesundh, 2022
Ehrentreich S, Metzner L, Deraneck S, Blavutskaya Z, Tschupke S, Hasseler M.   +5 more
europepmc   +1 more source

CREATIVE LEARNING METHODS DURING LEARNING THE EDUCATIONAL COMPONENT “FOREIGN LANGUAGE” BY STUDENTS OF THE FIRST (BACHELOR) LEVEL OF HIGHER EDUCATION (EXPERIENCE OF H.S. CKOVORODA NATIONAL UNIVERSITY OF APPLIED SCIENCES)

, 2023
Т. О. Разуменко
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Soft wearable thermo+touch haptic interface for virtual reality

iScience
Summary: Touch is an inherent source of tactile sensation in everyday life, followed by vision and audition. For rich tactile feedback, multimodal haptic feedback is necessary because a single touch simultaneously excites multiple types of tactile ...
Seohu Lee, Seongkwan Jang, Youngsu Cha
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

A data science approach to climate change risk assessment applied to pluvial flood occurrences for the United States and Canada [PDF]

Mathilde Bourget, Mathieu Boudreault, David A. Carozza, Jérémie Boudreault, Sébastien Raymond   +4 more
openalex   +1 more source

Multivariate Analysis Applied to Forestry Agricultural Sciences: The Model-Directed Study [PDF]

, 2018
Angela Helena Silva Mendes Stival, Gilberto de Oliveira, Jéssica Bezerra Bandeira, Josué Luiz Marinho, Larissa da Silva Cintra, Patrícia Cardoso Dias, Debora Portella Biz, Augustus Caeser Franke Portella   +7 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source