Results 151 to 160 of about 3,086,260 (319)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Multiple Importance Sampling ELBO and Deep Ensembles of Variational Approximations [PDF]

open access: green, 2022
Oskar Kviman   +4 more
openalex   +1 more source

Approximate Weights

open access: yesThe Annals of Mathematical Statistics, 1948
The greatest fractional increase in variance when a weighted mean is calculated with approximate weights is, quite closely, the square of the largest fractional error in an individual weight. The average increase will be about one-half this amount. The use of weights accurate to two significant figures, or even to the nearest number of the form: 10, 11,
openaire   +2 more sources

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

On coupled non-linear Schrödinger systems with singular source term

open access: yesAIMS Mathematics
This work studies a coupled non-linear Schrödinger system with a singular source term. First, we investigate the question of the local existence of solutions.
Saleh Almuthaybiri, Tarek Saanouni
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

КОМБИНИРОВАННЫЕ АППРОКСИМАЦИОННЫЕ МЕТОДЫ РЕШЕНИЯ ЗАДАЧ ГРАВИРАЗВЕДКИ И МАГНИТОРАЗВЕДКИ

open access: yesГеология и геофизика Юга России, 2018
В статье исследуется взаимосвязь различных вариантов метода линейных интегральных представлений. Комбинированные аппроксимации рельефа и геопотенциальных полей позволяют осуществить более тонкую «настройку» метода при решении обратных задач геофизики и ...
И.А. Керимов   +2 more
doaj  

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

open access: yesMolecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad   +35 more
wiley   +1 more source

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