Results 91 to 100 of about 1,005,063 (328)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Personalized Tour Itinerary Recommendation Algorithm Based on Tourist Comprehensive Satisfaction

Applied Sciences
Personalized travel itinerary recommendation algorithms are the focus of research in smart tourism and tourism GIS. Aiming to address issues present in travel itinerary recommendations for the increasingly popular “self-drive tour” mode, this study ...
Dingming Liu, Lizheng Wang, Yanling Zhong, Yi Dong, Jinling Kong   +4 more
doaj   +1 more source

An efficient 3-approximation algorithm for the Steiner tree problem with the minimum number of Steiner points and bounded edge length. [PDF]

PLoS One, 2023
Shin D, Choi S.
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

A Novel Method of Offset Approximation along the Normal Direction with High Precision

Mathematical and Computational Applications, 2017
A new algorithm is proposed for polynomial or rational approximation of the planar offset curve. The best rational Chebyshev approximation could be regarded as a kind of geometric approximation along the fixed direction.
Hongyan Zhao, Lian Zhou
doaj   +1 more source

A duality based 2-approximation algorithm for maximum agreement forest. [PDF]

Math Program, 2023
Olver N, Schalekamp F, van der Ster S, Stougie L, van Zuylen A.   +4 more
europepmc   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

A new 1.375-approximation algorithm for sorting by transpositions. [PDF]

Algorithms Mol Biol, 2022
Silva LAG, Kowada LAB, Rocco NR, Walter MEMT.   +3 more
europepmc   +1 more source

Approximating some network problems with scenarios

, 2018
In this paper the shortest path and the minimum spanning tree problems in a graph with $n$ nodes and $K$ cost scenarios (objectives) are discussed. In order to choose a solution the min-max criterion is applied.
Kasperski, Adam, Zielinski, Pawel
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source