Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
Approximation hardness of optimization problems in intersection graphs of d-dimensional boxes [PDF]
, 2005 The Maximum Independent Set problem in d-box graphs, i.e., in the intersection graphs of axis-parallel rectangles in R d , is a challenge open problem. For any fixed d ≥ 2 the problem is NP-hard and no approximation algorithm with ratio o(log d−1 n) is ...
Chlebikova, Janka +5 more
core
Approximation Algorithms for Node-Weighted Prize-Collecting Steiner Tree Problems on Planar Graphs [PDF]
, 2016 We study the prize-collecting version of the node-weighted Steiner tree problem (NWPCST) restricted to planar graphs. We give a new primal-dual Lagrangian-multiplier-preserving (LMP) 3-approximation algorithm for planar NWPCST.
Moldenhauer, Carsten +2 more
core +1 more source
A duality based 2-approximation algorithm for maximum agreement forest. [PDF]
Math Program, 2023 Olver N +4 more
europepmc +1 more source
The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Molecular Oncology, EarlyView.Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source
A new 1.375-approximation algorithm for sorting by transpositions. [PDF]
Algorithms Mol Biol, 2022 Silva LAG +3 more
europepmc +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Approximation algorithms for a sequencing problem with a biased bipartite structure
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2016 Given a family of m + 1 sets of n vertices in a metric space, a bi-level optimization problem to be considered in this paper asks to find a minimum cost repetitive walk with a prescribed terminal vertex.
Aleksandar SHURBEVSKI +2 more
doaj +1 more source
Approximation algorithm for rearrangement distances considering repeated genes and intergenic regions. [PDF]
Algorithms Mol Biol, 2021 Siqueira G +3 more
europepmc +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source