Results 61 to 70 of about 3,054,349 (257)

Algorithms for Scheduling Problems with Rejection

Tsinghua Science and Technology
We study scheduling problems with rejection on parallel-machine. Each job consists of a processing time, a rejection cost, and a release date. The goal is to minimize the makespan of the jobs accepted when the total rejection cost is not larger than a ...
Quanchang Zheng, Fanyu Kong, Jianfeng Ren, Yuzhong Zhang   +3 more
doaj   +1 more source

Approximation for Batching via Priorities [PDF]

Scientific Annals of Computer Science, 2007
We consider here the one-machine serial batching problem under weighted average completion. This problem is known to be $cal Ncal P$-hard and no good approximation algorithms are known. Batching has wide application in manufacturing, decision management,
W. Bein, J. Noga, J. Wiegley
doaj  

Detect Key Gene Information in Classification of Microarray Data

EURASIP Journal on Advances in Signal Processing, 2008
We detect key information of high-dimensional microarray profiles based on wavelet analysis and genetic algorithm. Firstly, wavelet transform is employed to extract approximation coefficients at 2nd level, which remove noise and reduce dimensionality ...
Yihui Liu
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

An improved Alpha approximation algorithm for time-series surface soil moisture inversion from Sentinel-1 SAR data

International Journal of Applied Earth Observations and Geoinformation
Accurate measurement of soil moisture content has significant scientific value and social benefits for studying global or regional water cycle mechanisms, developing climate and hydrological models, and advancing sustainable agricultural development. The
Leilei Dong, Tao Che, Xin Huang, Xingze Li, Haining Wei, Feinan Xu, Weizhen Wang   +6 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Trajectory Planning for Reconnaissance Mission Based on Fair-Energy UAVs Cooperation

IEEE Access, 2019
Unmanned aerial vehicles (UAVs) have recently received growing popularity in reconnaissance missions due to their many advantages, such as high mobility, flexible deployment, and low operational costs.
Zhen Qin, Chao Dong, Aijing Li, Haipeng Dai, Qihui Wu, Ai Xu   +5 more
doaj   +1 more source