Results 101 to 110 of about 129,306 (313)

Approximation algorithms for rectangle stabbing and interval stabbing problems. [PDF]

Inthe weighted rectangle stabbing problem we are given a grid in R2 consisting of columns and rows each having a positive integral weight, and a set of closed axis-parallel rectangles each having a positive integral demand.
Kovaleva, S, Spieksma, Frederik
core  

A Spatial Alignment Problem

Algorithms
This work concerns the harmonization of geospatial data to improve linkages between place-based characteristics and health outcomes. Such data are typically available as geographic layers, each representing a distinct attribute (e.g., income or distance ...
Armin R. Mikler, Chetan Tiwari, Murray Patterson   +2 more
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Szász–Beta Operators Linking Frobenius–Euler–Simsek-Type Polynomials

Axioms
This manuscript associates with a study of Frobenius–Euler–Simsek-type Polynomials. In this research work, we construct a new sequence of Szász–Beta type operators via Frobenius–Euler–Simsek-type Polynomials to discuss approximation properties for the ...
Nadeem Rao, Mohammad Farid, Shivani Bansal   +2 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Approximation Algorithms for Correlated Knapsack Orienteering [PDF]

We consider the correlated knapsack orienteering (CorrKO) problem: we are given a travel budget B, processing-time budget W, finite metric space (V,d) with root ρ ∈ V, where each vertex is associated with a job with possibly correlated random size and ...
Swamy, Chaitanya, Alemán Espinosa, David   +1 more
core   +1 more source

Improved Approximation Algorithms for Projection Games [PDF]

, 2013
The projection games (aka Label-Cover) problem is of great importance to the field of approximation algorithms, since most of the NP-hardness of approximation results we know today are reductions from Label-Cover.
Moshkovitz Aaronson, Dana Hadar, Dana Moshkovitz, Pasin Manurangsi, Manurangsi, Pasin   +3 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Better approximation guarantees for job-shop scheduling [PDF]

Job-shop scheduling is a classical NP-hard problem. Shmoys, Stein and Wein presented the first polynomial-time approximation algorithm for this problem that has a good (polylogarithmic) approximation guarantee.
Paterson, Michael S., Srinavasan, Aravind, Goldberg, Leslie Ann, Sweedyk, Elizabeth   +3 more
core