Results 91 to 100 of about 6,450,253 (299)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Adding Edges for Maximizing Weighted Reachability

Algorithms, 2020
In this paper, we consider the problem of improving the reachability of a graph. We approach the problem from a graph augmentation perspective, in which a limited set size of edges is added to the graph to increase the overall number of reachable nodes ...
Federico Corò, Gianlorenzo D'Angelo, Cristina M. Pinotti   +2 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Pade Method for Construction of Numerical Algorithms for Fractional Initial Value Problem

Journal of Mathematics, 2020
In this paper, we propose an efficient method for constructing numerical algorithms for solving the fractional initial value problem by using the Pade approximation of fractional derivative operators. We regard the Grunwald–Letnikov fractional derivative
Feng Gao, Chunmei Chi
doaj   +1 more source

Two-Agent Pareto-Scheduling of Minimizing Total Weighted Completion Time and Total Weighted Late Work

Mathematics, 2020
We investigate the Pareto-scheduling problem with two competing agents on a single machine to minimize the total weighted completion time of agent A’s jobs and the total weighted late work of agent B’s jobs, the B-jobs having a common due date.
Yuan Zhang, Zhichao Geng, Jinjiang Yuan
doaj   +1 more source

On Pseudodeterministic Approximation Algorithms.

, 2018
We investigate the notion of pseudodeterminstic approximation algorithms. A randomized approximation algorithm A for a function f is pseudodeterministic if for every input x there is a unique value v so that A(x) outputs v with high probability, and v is a good approximation of f(x).
Peter Dixon 0002, Aduri Pavan, N. V. Vinodchandran   +2 more
openaire   +3 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Approximation algorithms for spreading points

Journal of Algorithms, 2005
We consider the problem of placing n points, each one inside its own, prespecified disk, with the objective of maximizing the distance between the closest pair of them. The disks can overlap and have different sizes. The problem is NP-hard and does not admit a PTAS. In the L∞ metric, we give a 2-approximation algorithm running in $O(n{\sqrt n}log^{2}n)$
openaire   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source