Results 91 to 100 of about 54,203 (295)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
A numerical method for the computation of faber polynomials for starlike domains
, 1991 We describe a simple numerical process (based on the Theodorsen method for conformal mapping ) for computing approximations to Faber polynomials for starlike ...
Soares, M J +2 more
core
Approximation of classes of Poisson integrals by rectangular Fejér means
Frontiers in Applied Mathematics and StatisticsThe article is devoted to the problem of approximation of classes of periodic functions by rectangular linear means of Fourier series. Asymptotic equalities are found for upper bounds of deviations in the uniform metric of rectangular Fejér means on ...
Olga Rovenska
doaj +1 more source
The degree of approximation by polynomials on some disjoint intervals in the complex plane
Journal of Approximation Theory, 2007 Let \(f\) be a continuous function defined on the compact set \(K\) consisting of the union of several disjoint intervals in the complex plane. Using the overconvergence technique the author estimates lower bounds of the error \(E_n(f,K)=\inf_{P\in {\mathcal{P}}_n}\| f-P\|\) where inf is taken over all polynomials of degree at most \(n\).
openaire +2 more sources
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
SIMULTANEOUS APPROXIMATION AND INTERPOLATION OF FUNCTIONS ON CONTINUA IN THE COMPLEX PLANE
, 2001 We construct polynomial approximations of Dzjadyk type (in terms of the k-th modulus of continuity, k 1) for analytic functions defined on a continuum E in the complex plane, which simultaneously interpolate at given points of E. Furthermore, the error
Pritsker, I.E. +5 more
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Structured pseudospectra in structural engineering
, 2005 This paper presents a new method for computing the pseudospectra of a matrix that respects a prescribed sparsity structure. The pseudospectrum is defined as the set of points in the complex plane to which an eigenvalue of the matrix can be shifted by a ...
Wagenknecht, T, Agarwal, J
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Approximation of the Functions in Weighted Lebesgue Spaces With Variable Exponent
, 2018 In the present work, we investigate the approximation problems of the functions by Fejér, and Zygmund means of Fourier trigonometric series in weighted Lebesgue spaces with variable exponents and of the functions by Fejér and Abel–Poisson sums of Faber ...
Jafarov, S.Z.
core +1 more source