Results 111 to 120 of about 54,203 (295)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Analysis of a reaction-diffusion system of ƛ -w type [PDF]

, 2003
The author studies two coupled reaction-diffusion equations of 'ƛ - w' type, on an open, bounded, convex domain Ω C R(^d) (d ≤ 3), with a boundary of class C(^2), and homogeneous Neumann boundary conditions.
Garvie, Marcus Roland
core  

Comparison of different approaches to the numerical calculation of the LMJ focal

EPJ Web of Conferences, 2013
The beam smoothing in the focal plane of high power lasers is of particular importance to laser-plasma interaction studies in order to minimize plasma parametric and hydrodynamic instabilities on the target.
Bourgeade A., Coïc H., Goossens J.-P.
doaj   +1 more source

Simultaneous rational approximation of a function and its derivatives in the complex plane

Journal of Approximation Theory, 1985
Some aspects of simultaneous rational approximation of a function f(z) and its derivatives on the unit circle are investigated. The function f(z) is assumed to be analytic in some annulus containing the unit circle, and given a nonnegative integer \(\ell\), \(\| f\| =\max \{\| f^{(j)}\|_{p,1}:0\leq j\leq \ell \},\) where \(\| \cdot \|_{p,1}\) is the ...
Levin, A.L, Lubinsky, D.S
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The treatment of corner and pole-type singularities in numerical conformal mapping techniques

, 1984
This paper is a report of recent developments concerning the nature and the treatment of singularities that affect certain numerical conformal mapping techniques.
Warby, MK, Hough, DM, Papamichael, N
core  

FindSources3D - Source Localization Using Rational Approximation on Plane Sections [PDF]

, 2014
International audienceFindSource3D is a new method for EEG source localization based on rational approximation techniques in the complex plane. The method is used in the context of a nested sphere head model, in combination with a cortical mapping ...
Papadopoulo, Théodore, Clerc, Maureen, Waelkens, Andre, Marmorat, Jean-Paul, Leblond, Juliette, Jordanov, Todor   +5 more
core   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

On the Combination of the Laplace Transform and Integral Equation Method to Solve the 3D Parabolic Initial Boundary Value Problem

Axioms
We consider a two-step numerical approach for solving parabolic initial boundary value problems in 3D simply connected smooth regions. The method uses the Laplace transform in time, reducing the problem to a set of independent stationary boundary value ...
Roman Chapko, Svyatoslav Lavryk
doaj   +1 more source