Results 121 to 130 of about 148,991,006 (286)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

On the Combination of the Laplace Transform and Integral Equation Method to Solve the 3D Parabolic Initial Boundary Value Problem

Axioms
We consider a two-step numerical approach for solving parabolic initial boundary value problems in 3D simply connected smooth regions. The method uses the Laplace transform in time, reducing the problem to a set of independent stationary boundary value ...
Roman Chapko, Svyatoslav Lavryk
doaj   +1 more source

Greedy Thiele continued-fraction approximation on continuum domains in the complex plane

CoRR
We describe an adaptive greedy algorithm for Thiele continued-fraction approximation of a function defined on a continuum domain in the complex plane. The algorithm iteratively selects interpolation nodes from an adaptively refined set of sample points on the domain boundary.
Tobin A. Driscoll, Yuxing Zhou
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Stability of Plane Wave Solutions in Complex Ginzburg--Landau Equation with Delayed Feedback

, 2014
We perform bifurcation analysis of plane wave solutions in a one-dimensional complex cubic-quintic Ginzburg--Landau equation with delayed feedback.
Vladimirov, Andrei G., Puzyrev, Dmitry, Gurevich, Svetlana V., Yanchuk, Serhiy   +3 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Complex methods in approximation theory

, 1997
Centro de Informacion y Documentacion Cientifica (CINDOC). C/Joaquin Costa, 22. 28002 Madrid.
Moreno Balcazar, J.J. (eds.), Marcellan EspaNol, F., Almeria Univ. (Spain), Martinez Finkelshtein, A.   +3 more
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

SIMULTANEOUS APPROXIMATION AND INTERPOLATION OF FUNCTIONS ON CONTINUA IN THE COMPLEX PLANE

, 2001
We construct polynomial approximations of Dzjadyk type (in terms of the k-th modulus of continuity, k 1) for analytic functions defined on a continuum E in the complex plane, which simultaneously interpolate at given points of E. Furthermore, the error
Pritsker, I.E., Andrievskii, V.V., Vladimir V. Andrievskii, Richard S. Varga, Varga, R.S., Igor E. Pritsker   +5 more
core