Results 71 to 80 of about 9,849,612 (295)

The approximation order of polysplines [PDF]

Proceedings of the American Mathematical Society, 2003
We show that the scaling spaces defined by the polysplines of order p p provide approximation order
Kounchev, Ognyan, Render, Hermann
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Wavelet-Based High-Order Adaptive Modeling of Lossy Interconnects [PDF]

, 2001
—This paper presents a numerical-modeling strategy for simulation of fast transients in lossy electrical interconnects. The proposed algorithm makes use of wavelet representations of voltages and currents along the structure, with the aim of reducing the
S. Grivet-talocia, F. Canavero, Grivet-Talocia, S., GRIVET TALOCIA, STEFANO, Canavero, Flavio   +4 more
core   +1 more source

A logarithmic approximation of linearly ordered colourings

CoRR
A linearly ordered (LO) $k$-colouring of a hypergraph assigns to each vertex a colour from the set $\{0,1,\ldots,k-1\}$ in such a way that each hyperedge has a unique maximum element. Barto, Batistelli, and Berg conjectured that it is NP-hard to find an LO $k$-colouring of an LO 2-colourable 3-uniform hypergraph for any constant $k\geq 2$ [STACS'21 ...
Håstad, J, Martinsson, B, Nakajima, T-V, Zivny, S   +3 more
openaire   +7 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Rational approximation of arbitrary order operators-Strange scaling equations

四川大学学报. 自然科学版, 2020
Two new types of irregular scaling equations-strange scaling equations are obtained by the continuous expansion method and scale expansion theory. This paper explores the differences and advantages of the rational function sequences of strange scaling ...
GUO ZhaoRu, HE QiuYan, YUAN Xiao, PU YiFei   +3 more
doaj  

Approximate Solutions to Games of Ordered Preference

2025 IEEE 28th International Conference on Intelligent Transportation Systems (ITSC)
Autonomous vehicles must balance ranked objectives, such as minimizing travel time, ensuring safety, and coordinating with traffic. Games of ordered preference effectively model these interactions but become computationally intractable as the time horizon, number of players, or number of preference levels increase.
Pau de las Heras Molins, Eric Roy-Almonacid, Dong Ho Lee, Lasse Peters, David Fridovich-Keil, Georgios Bakirtzis   +5 more
openaire   +4 more sources

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source