Results 61 to 70 of about 164,476 (314)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Lagrange approximation in Banach spaces [PDF]
Czechoslovak Mathematical Journal, 2015 Using an integral representation formula for holomorphic functions on Banach spaces combined with Lagrange interpolation of the exponential function \(e^z\) in the complex plane, the authors define Lagrange interpolating polynomials for representable functions defined on a Banach space \(E\).
Nilsson, Lisa +2 more
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Approximate property of a functional equation with a general involution
Demonstratio Mathematica, 2018 In this paper, we prove the Hyers-Ulam stability of the functional equation f(x + y, z + w) + f(x + σ(y),z + τ(w)) = 2f(x, z) + 2f(y, w), where σ, τ are involutions.
Park Won-Gil, Bae Jae-Hyeong
doaj +1 more source
Zeitschrift für Analysis und ihre Anwendungen, 1989 The paper deals with characterizations of spaces F^s_{pq} and B^s_{pq} on \mathbb R^n, \mathbb R^n_+
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LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Approximation in trigonometric Lipschitz spaces
, 2021 The approximation by generalized trigonometric polynomials for Lipschitz defined functions in certain groups depends on some properties of the group defined metric. Metrics which allow this approximation are called Lipschitz compatible. In this work we give for certain class of groups, conditions under which Lipschitz compatible metrics are boundedly ...
Bernabé Loranca, María Beatriz +3 more
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Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Topological Structure of Generalized Rough Graphs
Ibn Al-Haitham Journal for Pure and Applied Sciences, 2020 The main purpose of this paper, is to introduce a topological space , which is induced by reflexive graph and tolerance graph , such that may be infinite.
Samah Sarmad, Yousif Yaqoub Yousif
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Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source