Results 61 to 70 of about 791,635 (286)

Approximate inference techniques with expectation constraints [PDF]

open access: yesJournal of Statistical Mechanics: Theory and Experiment, 2005
This paper discusses inference problems in probabilistic graphical models that often occur in a machine learning setting. In particular it presents a unified view of several recently proposed approximation schemes. Expectation consistent approximations and expectation propagation are both shown to be related to Bethe free energies with weak consistency
Heskes, T.M.   +4 more
openaire   +4 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Transport user benefits calculation with the “Rule of a Half” for travel demand models with constraints [PDF]

open access: yes, 2013
The importance of user benefits in transport projects assessments is well-known by transport planners and economists. Generally they have the greatest impact on the result of costbenefit analysis.
Winkler, Christian
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Study of the Boundary Value Problems for Nonlinear Wave Equations on Domains with a Complex Structure of the Boundary and Prehistory

open access: yesMathematics, 2021
We study a boundary value problem for nonlinear partial differential equations of the hyperbolic type on the plain in a domain with a complex boundary.
Vasyl Marynets   +2 more
doaj   +1 more source

Approximation with interpolatory constraints

open access: yesJournal of Mathematical Analysis and Applications, 1978
AbstractBest approximation with interpolatory constraints is considered. A sufficient condition for an approximating function to be a unique best approximation is presented. A necessary condition is deduced if uniqueness holds.
openaire   +3 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

Approximation algorithms for channel assignment with constraints

open access: yesTheoretical Computer Science, 1999
Cellular networks are generally modeled as node-weighted graphs, where the nodes represent cells and the edges represent the possibility of radio interference. An algorithm for the channel assignment problem must assign as many channels as the weight indicates to every node, such that any two channels assigned to the same node satisfy the co-site ...
Janssen, Jeannette, Narayanan, Lata
openaire   +2 more sources

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