Results 111 to 120 of about 5,560 (153)

Aprepitant ameliorates vancomycin-induced kidney injury: Role of GPX4/system Xc- and oxidative damage.

Food and Chemical Toxicology
Vancomycin, a glycopeptide antibiotic, is used in cases of drug-resistant bacterial infections, but unfortunately is associated with acute kidney injury (AKI).
Maha H. Sharawy, Ahmed M. Abdel-Rahman, Noha Abdel-Rahman   +2 more
semanticscholar   +1 more source

Cannabinoid Hyperemesis Syndrome in Adolescents: The Role of Aprepitant as a New Treatment Option for Rapid Symptom Relief.

Journal of Adolescent Health
Cannabinoid hyperemesis syndrome (CHS) is a growing clinical concern among adolescents, which is marked by recurrent episodes of nausea, vomiting, and abdominal pain related to chronic cannabis use.
Anat Sigal, Gabrielle Padilla, Taryn Carroll, Susan G. Mautone   +3 more
semanticscholar   +1 more source

Aprepitant boasted a protective effect against olanzapine-induced metabolic syndrome and its subsequent hepatic, renal, and ovarian dysfunction; Role of IGF1/p-AKT/FOXO1 and NFκB/IL-1β/TNF-α signaling pathways in female Wistar albino rats.

Biochemical Pharmacology
Olanzapine-induced metabolic syndrome (MS) is a primary risk factor for insulin resistance, hepatorenal damage, and polycystic ovarian syndrome. The objective of the current study was to assess the protective effects of aprepitant (AP) against MS caused ...
Reham H. Mohyeldin, W. Abdelzaher, Ehab E. Sharata, H. M. Mohamed, M. Ahmed, Josef Zekry Attia, Medhat Atta, R. K. Saleh, Elshimaa A Ghallab, Heba Marey, M. Elrehany, R. Rofaeil   +11 more
semanticscholar   +1 more source

Neurokinin‐1 receptor antagonist aprepitant regulates autophagy and apoptosis via ROS/JNK in intrahepatic cholangiocarcinoma

Liver international (Print)
Intrahepatic cholangiocarcinoma (iCCA) has a poor prognosis and limited treatment options. Aprepitant, a selective NK‐1R antagonist, can inhibit the growth of various tumours in vitro and in vivo.
Yang Yang, Xueyan Cao, Yuting Wang, Xinyu Wu, Ping Zhou, Lin Miao, Xueting Deng   +6 more
semanticscholar   +1 more source

Aprepitant

Reactions Weekly, 2021
  +5 more sources

Aprepitant exerts anti-fibrotic effect via inhibition of TGF-β/Smad3 pathway in Bleomycin-induced pulmonary fibrosis in rats.

Environmental Toxicology and Pharmacology, 2022
Bleomycin is a well-recognized antineoplastic drug. However, pulmonary fibrosis (PF) is considered to be the principal drawback that greatly limits its use.
Mervat Z. Mohamed, Mohamed F Abed El Baky, Merhan E. Ali, H. Hafez   +3 more
semanticscholar   +1 more source

Combination Therapy of Chemotherapy or Radiotherapy and the Neurokinin-1 Receptor Antagonist Aprepitant: A New Antitumor Strategy?

Current Medicinal Chemistry, 2022
BACKGROUND Although chemotherapy is predominantly used for cancer treatment, it can be ineffective, and can induce serious side effects and lead to chemoresistance.
P. Robinson, R. Coveñas, M. Muñoz
semanticscholar   +1 more source

Health-Related Quality of Life And Economic Analysis of Olanzapine Versus Aprepitant in Preventing Chemotherapy-Induced Nausea and Vomiting in Patients Receiving Highly Emetogenic Chemotherapy in Malaysia.

Value in Health Regional Issues
OBJECTIVES Olanzapine has been shown to be effective in preventing chemotherapy-induced nausea and vomiting (CINV) after highly emetogenic chemotherapy (HEC); however, there is limited work on the impact of CINV on health-related quality of life (HRQoL ...
Nurul Suhaida Badarudin, N. Mohamed Shah, N. A. Mohd Tahir, Azmi Nor Mohd Farez Ahmat, Fuad Ismail, F. Islahudin, S. Yusak, Syahir Muhammad, Kamarun Neasa Begam Mohd Kassim   +8 more
semanticscholar   +1 more source

Aprepitant mitigates paclitaxel-induced neuropathic pain in rats via suppressing inflammatory pathways in dorsal root ganglia

Drug and chemical toxicology (New York, N.Y. 1978)
Neuropathic pain is the crucial dose-limiting side effect of paclitaxel in chemotherapy patients that negatively impacts the quality of life and survival. Currently, no effective treatment option is available.
Mina Khalilzadeh, Moein Ghasemi, Hedyeh Faghir‐Ghanesefat, Mahnoosh Ghafouri Esfahani, Ahmad-Reza Dehpour, Hamed Shafaroodi   +5 more
semanticscholar   +1 more source

Repurposing Aprepitant: Can it protect against doxorubicin-induced Chemobrain beyond its antiemetic role?

Life Science
The substance P (SP) and neurokinin-1 receptor (NK-1R) axis is crucial in numerous pathological processes, including inflammation, stress responses, pain perception, and vomiting.
Asmaa A Gomaa, D. Abdallah, H. El-Abhar, Bassant M. El-Mokadem   +3 more
semanticscholar   +1 more source