Results 11 to 20 of about 8,326 (241)

The NK-1R Antagonist Aprepitant Prevents LPS-Induced Oxidative Stress and Inflammation in RAW264.7 Macrophages

Drug Design, Development and Therapy, 2020
Xiao-nan Zhao,* Zhen-zi Bai,* Cheng-hua Li, Chuan-lun Sheng, Hong-yan Li Department of Infectious, The Third Hospital of Jilin University, Changchun City, Jilin Province 130033, People’s Republic of China*These authors contributed equally to this ...
Zhao X, Bai Z, Li C, Sheng C, Li H
doaj   +1 more source

Diagnostic and Therapeutic Potential of Substance P/NK1 Receptor in Primary Dysmenorrhea: A Pilot Study. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Primary dysmenorrhea is a prevalent condition that causes significant menstrual pain and discomfort, impacting many women′s daily activities. The Substance P/NK1 receptor (SP/NK1R) pathway has been linked to the pain mechanisms underlying dysmenorrhea, yet its potential as a therapeutic target remains inadequately explored.
Mehboob R, Shahid I, Alzahrani AR, Yousof SM, Adnan H, Ekram SN, Alwazzan A, Nasief H, Khadawardi KA.   +8 more
europepmc   +2 more sources

Aprepitant inhibits the development and metastasis of gallbladder cancer via ROS and MAPK activation

BMC Cancer, 2023
Background Aprepitant, as a neurokinin-1 receptor (NK-1R) antagonist, originally applied for curing chemotherapy-induced nausea and vomiting, has been reported to have significant antitumor effect on several malignant tumors.
Xueyan Cao, Yang Yang, Wei Zhou, Yue Wang, Xue Wang, Xianxiu Ge, Fei Wang, Fangfang Zhou, Xueting Deng, Lin Miao   +9 more
doaj   +1 more source

The use of aprepitant in the first cycle of moderately emetogenic chemotherapy in patients with colorectal cancer: its preventive effect on chemotherapy-induced nausea and vomiting [PDF]

Korean Journal of Clinical Oncology, 2013
Purpose: There have been fever studies about the effectiveness of aprepitant in the first cycle of moderately emetogenic chemotherapy. The aim of this study was to determine whether aprepitant shows the effectiveness for prevention of chemotherapy ...
Jung Won Ryu, Sun Jin Park, Min-Su Park, Jin Seop Kim, Kil Yeon Lee   +4 more
doaj   +1 more source

Targeting tachykinin receptors in neuroblastoma [PDF]

, 2016
Neuroblastoma is the most common extracranial tumor in children. Despite aggressive multimodal treatment, high-risk neuroblastoma remains a clinical challenge with survival rates below 50%.
Althoff, Kristina, Astrahanseff, Kathy, Beckers, Anneleen, Bergmann, Andreas, De Preter, Katleen, Eggert, Angelika, Henssen, Anton G, Odersky, Andrea, Schramm, Alexander, Schulte, Johannes H, Schäfers, Simon, Seiler, Marleen, Speleman, Franki, Struck, Joachim, Szymansky, Annabell   +14 more
core   +7 more sources

Cost-Effectiveness of Aprepitant in Preventing Chemotherapy-Induced Nausea and Vomiting: A Systematic Review of Published Articles

Frontiers in Public Health, 2021
Objectives: The aim of this systematic review is to assess the published cost-effectiveness analyses of aprepitant for patients with chemotherapy-induced nausea and vomiting (CINV).Methods: A systematic literature search was performed on PubMed, EMbase ...
Tingting Qiu, Tingting Qiu, Peng Men, Peng Men, Tong Sun, Suodi Zhai, Suodi Zhai   +6 more
doaj   +1 more source

Design and Characterization of Phosphatidylcholine-Based Solid Dispersions of Aprepitant for Enhanced Solubility and Dissolution

Pharmaceutics, 2020
This study aimed to improve the solubility and dissolution of aprepitant, a drug with poor aqueous solubility, using a phosphatidylcholine (PC)-based solid dispersion system.
Sooho Yeo, Jieun An, Changhee Park, Dohyun Kim, Jaehwi Lee   +4 more
doaj   +1 more source

Influence of aprepitant on the pharmacodynamics and pharmacokinetics of gliclazide in rats and rabbits [PDF]

PeerJ, 2018
Background Concomitant drug administration is a general phenomenon in patients with chronic diseases such as diabetes mellitus. Among the currently available oral antidiabetic drugs, gliclazide is a commonly prescribed drug considering its multiple ...
Raghunandan Reddy Kura, Eswar Kumar Kilari, Mastan Shaik   +2 more
doaj   +2 more sources

Aprepitant Inhibits JNK and p38/MAPK to Attenuate Inflammation and Suppresses Inflammatory Pain

Frontiers in Pharmacology, 2022
Substance P contributes to the pathogenesis of pain by acting on NK-1R, specialized sensory neurons that detect noxious stimuli. Aprepitant, an antagonist of NK-1R, is widely used to treat chemotherapy-induced nausea and vomiting.
Yang Yang, Wei Zhou, Xiuqi Xu, Xianxiu Ge, Fei Wang, Guang-Qin Zhang, Lin Miao, Xueting Deng   +7 more
doaj   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source