Results 41 to 50 of about 5,560 (153)

Preparation and Characterization of Aprepitant Solid Dispersion with HPMCAS-LF

ACS Omega, 2022
This study focused on improving the physicochemical characteristics of aprepitant with poor water solubility by preparing solid dispersion (SD). To prepare the SD with HPMCAS-LF, the solvent evaporation method was applied.
Jinwen Liu, Yongji Li, Wuliji Ao, Ying Xiao, Meirong Bai, Shuyan Li   +5 more
semanticscholar   +1 more source

A phase 1 study of berzosertib (M6620, VX‐970) in combination with cisplatin and radiation in patients with locally advanced head and neck squamous cell carcinoma (ETCTN 9950)

Cancer, Volume 132, Issue 6, 15 March 2026.
ABSTRACT Background Ataxia telangiectasia Rad3‐related (ATR) protein kinase regulates DNA damage response and is essential for tumor cell survival. Preclinically, ATR inhibition can sensitize tumor cells to radiation and chemotherapy. The authors conducted a phase 1 trial of berzosertib, a selective ATR inhibitor, in combination with definitive ...
Aarti Bhatia, Zhengjia Chen, Yuji Zhang, Justine Yang Bruce, Susanne Arnold, Varinder Kaur, Jonathan W. Riess, Moon Fenton, Barbara Burtness, Nabil F. Saba, Harold Tara, Conor E. Steuer, Dong M. Shin, Garrett Wasp, Thomas H. Davis, Malini Patel, John C. Schmitz, Priyanka Bhateja, Virginia Diavolitsis, Dan P. Zandberg, Darrion L. Mitchell, Brian F. Kiesel, Charles Kunos, Steven D. Gore, Michael Carducci, Jan H. Beumer, Taofeek K. Owonikoko   +26 more
wiley   +1 more source

PVP/aprepitant microcapsules produced by supercritical antisolvent process

Scientific Reports
The supercritical antisolvent (SAS) process was a green alternative to improve the low bioavailability of insoluble drugs. However, it is difficult for SAS process to industrialize with limited production capacity.
Zhuo Zhang, Guizhou Hao, Xuemei Sun, Feibo Wang, Dengbo Zhang, Dedong Hu   +5 more
semanticscholar   +1 more source

Progress in Gastroparesis Management: From Pharmacotherapy to Interventional Treatments

JGH Open, Volume 10, Issue 3, March 2026.
ABSTRACT Gastroparesis is a sensorimotor condition characterized by delayed gastric emptying without any obvious mechanical obstruction. Common symptoms include early satiety, nausea, vomiting, belching, and bloating. The most frequent causes of gastroparesis are diabetes, idiopathic factors, and post‐surgical complications.
Ganesh Kumar, Yash Shah, Ume Rooman, Ravi Patel, Shireen Asifa, Qais M. Salah, Dushyant Singh Dahiya, Arkadeep Dhali, Camelia Arsene, Meer Ali   +9 more
wiley   +1 more source

Impact of grinding balls on the size reduction of Aprepitant in wet ball milling procedure

Pharmaceutical development and technology (Print)
One of the widely used approaches for improving the dissolution of poorly water-soluble drugs is particle size reduction. Ball milling is a mechanical, top-down technique used to reduce particle size.
Dourna Memarvar, Shadi Yaqoubi, Hamed Hamishehkar, Matthew Lam, A. Nokhodchi   +4 more
semanticscholar   +1 more source

Society for Maternal‐Fetal Medicine Consult Series #76: Cancer in pregnancy

Pregnancy, Volume 2, Issue 2, March 2026.
Abstract Approximately one in 1000 pregnancies is complicated by the diagnosis of cancer each year, and the incidence of cancer among reproductive‐age individuals is increasing. Management of a pregnant person with cancer can be complex and warrants a multidisciplinary approach to care.
Society for Maternal‐Fetal Medicine (SMFM), Moti Gulersen, Clarissa Bonanno, Justin S. Brandt, Stephanie Pierce, Elyce H. Cardonick, SMFM Publications Committee   +6 more
wiley   +1 more source

Aprepitant Restores Corneal Sensitivity and Reduces Pain in DED

Translational Vision Science & Technology
Purpose This study aims to assess the efficacy of two aprepitant formulations (X1 and X2), in a preclinical model of dry eye disease (DED) induced by benzalkonium chloride (BAK).
Filippo Bonelli, Fabiola Campestre, R. L. Lasagni Vitar, Ibrahim Demirsoy, P. Fonteyne, Giulio Ferrari   +5 more
semanticscholar   +1 more source

A Blood‐Brain Barrier‐Penetrant Ag(III) Corrole Compound Rescues Alzheimer's Disease Pathology by Targeting Aβ42‐Induced Oxidative Stress

Advanced Science, Volume 13, Issue 8, 9 February 2026.
The newly designed metallo‐corrole (Mor‐Cor)Ag(III) with a morpholino group exhibited promising therapeutic potential for Alzheimer's disease. It significantly reduces reactive oxygen species (ROS), decreases GFAP expression, increases neurite length, and decreases cell death compared to other similar metallo‐corroles. Abstract Alzheimer's disease (AD)
Arup Tarai, Tuhina Mitra, Tanmoy Pain, Jyotiprakash Mallick, Rwiddhi Chakraborty, Kallam Tejaswi, Swagata Ghatak, Sanjib Kar   +7 more
wiley   +1 more source

Safety and Efficacy of Concomitant Administration of Nanoliposomal Irinotecan + 5‐Fluorouracil/Levo‐Leucovorin for Pancreatic Cancer

Cancer Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background Nanoliposomal irinotecan (nal‐IRI) plus 5‐fluorouracil (5‐FU)/levo‐leucovorin (Levo‐LV) therapy is recommended as the standard of care for unresectable locally advanced (UR‐LA) and metastatic pancreatic cancer after failure of gemcitabine‐containing regimens.
Akane Wakabayashi, Rei Tanaka, Yurie Fukumuro, Keita Mori, Junya Sato, Hiroshi Ishikawa, Michihiro Shino, Takeshi Kawakami   +7 more
wiley   +1 more source

Anticancer Molecular Mechanisms of Curcuminoids: An Updated Review of Clinical Trials

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Curcuminoids remain one of the most studied dietary polyphenols as a cancer prevention and treatment agent. Inflammation and tumor progression are related to the NF‐κB signaling pathway, which is also suppressed by curcuminoids. Curcuminoids prevent the activation of a variety of signaling pathways, including the MAPK, PI3K/Akt, and NF‐kB pathways ...
Ushna Momal, Muhammad Shahbaz, Asfa Perween, Muhammad Hammad ul Hassan, Hammad Naeem, Zubda Shahid, Muzzamal Hussain, Muhammad Imran, Suliman A. Alsagaby, Waleed Al Abdulmonem, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Tadesse FentaYehuala, Samy Selim, Ehab M. Mostafa   +14 more
wiley   +1 more source