Results 101 to 110 of about 111,375 (229)
Inhibition of Intrinsic Thrombin Generation
Drug Target Insights, 2006 Background: The contact phase of coagulation is of physiologic/pathophysiologic importance, whenever unphysiologic polynegative substances such as cell fragments (microparticles) get in contact with blood.
Thomas W. Stief
doaj
Pharmacology Research &Perspectives, Volume 13, Issue 3, June 2025.ABSTRACT St John's Wort (SJW), commonly used to treat mild depression, is known to pose a risk of drug–herb interactions through hyperforin‐mediated activation of the pregnane X receptor (PXR). This induces transcription and expression of PXR target genes, including the efflux transporter P‐glycoprotein (Pgp).
Valerio Taggi +3 more
wiley +1 more source
Journal of Food Science, Volume 90, Issue 6, June 2025.ABSTRACT Hydrolyzed egg yolk peptides have been proven to improve bone density in animals of different ages. However, the peptides profile and function of low molecular weight hydrolyzed egg yolk peptides have not been studied, which may have better efficacy, the relationship between these peptides and humoral immunity has not been noticed yet.
Weiying Luan +9 more
wiley +1 more source
The effects of the protease inhibitor, aprotinin, on the course of shock induced by endotoxin in cats [PDF]
, 1985 B. Hughes, J. R. Parratt
openalex +1 more source
Deciphering the Contribution of Circular RNAs to Age‐Related Decline in Sertoli Cell Survivor
Aging Cell, Volume 24, Issue 6, June 2025.Sertoli cell survival is regulated by circAbcb9‐ceRNET. Physiologically, the circAbcb9 sponge activity toward miR‐214‐3p ensures the expression of SOX8 and NOTCH2 targets, both crucial in maintaining SC homeostasis. The aging process negatively affects FUS‐dependent backsplicing activity in Sertoli cells leading to circAbcb9 downregulation, and in turn,
Francesco Manfrevola +11 more
wiley +1 more source
Engineered pulmonary artery tissues for measuring contractility, drug testing and disease modelling
British Journal of Pharmacology, Volume 182, Issue 12, Page 2585-2602, June 2025.Abstract Background and Purpose Vasoreactivity of pulmonary arteries regulates blood flow through the lungs. Excessive constriction of these vessels contributes to pulmonary arterial hypertension (PAH), a progressive and incurable condition, resulting in right heart failure.
Adam L. Fellows +8 more
wiley +1 more source
Journal of Education, Health and Sport, 2016 Lyoshenko I. A., Tarabrin O. A., Holubenko M. Yu., Havrichenko D. H. The use of inhibitors of fibrinolysis in the treatment of obstetric hemorrhage due to placenta detachment. Journal of Education, Health and Sport. 2016;6(1):129-137.
Irina A. Lyoshenko +3 more
doaj
Low‐Glucose Culture Conditions Bias Neuronal Energetics Towards Oxidative Phosphorylation
Journal of Neurochemistry, Volume 169, Issue 6, June 2025.Historically, in vitro primary neuronal cultures include 25 mM glucose, making it artificially hyperglycemic. In this article, Swain, et al., show that relatively pure forebrain neuronal cultures can be grown and maintained in 5 mM glucose media for up to 2 weeks, with negligible effects on morphology or synaptogenesis.
Sarpras Swain +6 more
wiley +1 more source
Pilotstudie zur intraoperativen Aprotinin-Applikation bei Patienten mit Rektumtumoren und ihre Auswirkung auf Transfusionsbedarf und Blutverlust [PDF]
, 2002 Im Rahmen dieser Arbeit wurde eine randomisierte, plazebokontrollierte Doppelblindstudie durchgeführt, in der Patienten mit Rektumkarzinom intraoperativ den Serinprotinasen-Inhibitor Aprotinin erhielten. Hauptziel dieser Studie war es, durch die Gabe von
Heckl, Ute
core
Injured tissues favor cancer cell implantation via fibrin deposits on scar zones
Neoplasia: An International Journal for Oncology Research, 2020 Aim: Evaluation of fibrin role on cancer cells implantation in injured tissues and studying the molecular mechanism of cancer cell interaction with the peritoneal damage.
Iman Al dybiat +8 more
doaj