Results 101 to 110 of about 103,741 (231)
Journal of Cellular Physiology, Volume 241, Issue 3, March 2026.ABSTRACT Platelets, as anucleate blood cells, play a pivotal role in the pathogenesis of cardiovascular diseases (CVDs), making antiplatelet therapy essential for preventing thrombotic events such as myocardial infarction. Thromboxane A₂ (TXA₂) is a key pro‐aggregatory mediator that drives platelet activation.
Joen‐Rong Sheu +6 more
wiley +1 more source
Protein Science, Volume 35, Issue 3, March 2026.Abstract Cysteine biosynthesis in bacteria proceeds primarily via the de novo pathway, involving serine acetyltransferase (CysE) and O‐acetylserine sulfhydrylase (OASS). This pathway is absent in humans, and its inhibition impairs microbial fitness, virulence, and antibiotic resistance, making its enzymes attractive antimicrobial targets. Most bacteria
Noemi Massa +10 more
wiley +1 more source
Inhibition of Intrinsic Thrombin Generation
Drug Target Insights, 2006 Background: The contact phase of coagulation is of physiologic/pathophysiologic importance, whenever unphysiologic polynegative substances such as cell fragments (microparticles) get in contact with blood.
Thomas W. Stief
doaj
Aging Triggers an Intestinal Energy Crisis and HDL3 Deficiency Disrupting Gut–Liver Axis Homeostasis
Aging Cell, Volume 25, Issue 3, March 2026.The age‐related mitochondrial energy crisis and the consequent disruption of intestinal HDL3 biosynthesis converge to disrupt the gut–liver HDL3‐LPS/TLR4 axis, compromising hepatic anti‐inflammatory function and driving liver injury, an effect reversible upon NMN administration.
Yumeng Li +7 more
wiley +1 more source
Experimental Physiology, Volume 111, Issue 3, Page 798-808, 1 March 2026.Abstract Trimethylamine N‐oxide (TMAO) is linked to arterial stiffness and atherosclerosis. Cardiovascular disease (CVD) risk increases following menopause in women. Whether menopause influences plasma TMAO metabolism to mediate CVD risk is unknown.
Daniel J. Battillo, Steven K. Malin
wiley +1 more source
Downregulation of microRNA‐494 drives mitochondrial biogenesis and function in trained muscle
Experimental Physiology, Volume 111, Issue 3, Page 1093-1108, 1 March 2026.Abstract MicroRNAs (miRNAs) are key regulators of cellular processes, including mitochondrial function and energy metabolism. This study explores the regulation of miR‐494 in skeletal muscle and circulation, investigating its response to exercise training and an acute exercise bout, its association with metabolic disorders, and the effects of ...
Natália Pálešová +10 more
wiley +1 more source
Runx2 Regulated Airway Homeostasis Is Disrupted in Asthma
The FASEB Journal, Volume 40, Issue 4, 28 February 2026.Runt‐related transcription factor‐2 (RUNX2) expression and regulation of airway remodeling factors were examined in asthmatic and nonasthmatic airway smooth muscle (ASM) cells. Regulation by transforming growth factor‐β of active RUNX2 isoform translocation to the nucleus was absent in asthmatic ASM, while RUNX2 overexpression suppressed markers of ...
Junfei Wang +13 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 4, 28 February 2026.Growth hormone (GH) activates GHR at the primary cilium and stimulates centrosomal JAK2. JAK2 centrosomal localization requires both its SH2 domain and kinase activity. Cells expressing JAK2 variants deficient in centrosomal targeting show impaired control of cilia length, reduced proliferation, and cell migration compared with parental and JAK2 WT ...
Gaurab Karki +7 more
wiley +1 more source
Journal of Education, Health and Sport, 2016 Lyoshenko I. A., Tarabrin O. A., Holubenko M. Yu., Havrichenko D. H. The use of inhibitors of fibrinolysis in the treatment of obstetric hemorrhage due to placenta detachment. Journal of Education, Health and Sport. 2016;6(1):129-137.
Irina A. Lyoshenko +3 more
doaj