Results 91 to 100 of about 74,076 (196)

Engineered aprotinin for improved stability of fibrin biomaterials

, 2011
Fibrin has been long used clinically for hemostasis and sealing, yet extension of use in other applications has been limited due to its relatively rapid resorption in vivo, even with addition of aprotinin or other protease inhibitors.
Hubbell, J.A., Lorentz, Kristen Marie, Jeffrey A. Hubbell, Hubbell, Jeffrey Alan, Kristen M. Lorentz, Stephan Kontos, Frey, Peter, Lorentz, K.M., Peter Frey, Kontos, S., Frey, P., Kontos, Stephan   +11 more
core   +1 more source

Mechanisms underlying local Ca2+ signalling differences between right and left atrial myocytes at normal and increased frequencies

The Journal of Physiology, EarlyView.
Abstract figure legend Left atrial myocytes have TAT‐associated faster Ca2+ release but are more prone to maladaptation at higher frequencies due to weaker peripheral SR Ca2+ uptake and smaller trigger Ca2+ current. Abstract Changes in heart rate affect Ca2+ signalling and contractility in ventricular muscle, but the effects on atrial Ca2+ signalling ...
Joon‐Chul Kim, Hieu Trong Huynh, Phuong Kim Luong, Tran Nguyet Trinh, Yixuan Wu, Eleonora Grandi, Sun‐Hee Woo   +6 more
wiley   +1 more source

Skeletal muscle proteomics links mitochondrial abundance with peak fat oxidation in physically active young males

The Journal of Physiology, EarlyView.
Abstract figure legend This study used a non‐targeted proteomic approach to explore the skeletal muscle determinants of peak fat oxidation (PFO) and the exercise intensity at which this occurs (Fatmax). Comprehensive physiological phenotyping was completed in young, lean, physically active males, including blood and skeletal muscle sampling.
Eloise K. Tarry, Shaun Mason, Ghazanfar Abbas Khan, Sofie G. Vestergaard, Emilie A. Petersen, Mike C. Olsen, Maria Hansen, Arthur Ingersen, Kirsten F. Howlett, Steen Larsen, Christopher S. Shaw, Jørn W. Helge   +11 more
wiley   +1 more source

The role of fibrinolysis inhibition in engineered vascular networks derived from endothelial cells and adipose-derived stem cells

Stem Cell Research & Therapy, 2018
Background Co-cultures of endothelial cells with mesenchymal stem cells currently represent one of the most promising approaches in providing oxygen and nutrient supply for microvascular tissue engineering.
Severin Mühleder, Karoline Pill, Mira Schaupper, Krystyna Labuda, Eleni Priglinger, Pablo Hofbauer, Verena Charwat, Uwe Marx, Heinz Redl, Wolfgang Holnthoner   +9 more
doaj   +1 more source

Voltage‐gated potassium channels mediate thyroid hormone control of skeletal muscle excitability

The Journal of Physiology, EarlyView.
Abstract figure legend Thyroid hormone (TH)‐dependent remodelling of potassium (K+) channel networks regulates skeletal muscle (SkM) excitability. Triiodothyronine (T3), locally generated from thyroxine (T4) by type 2 deiodinase (D2), binds thyroid hormone receptors (TRα/β) and modulates transcription via thyroid response elements (TREs).
Annarita Nappi, Caterina Miro, Annunziata Gaetana Cicatiello, Ilaria Piccialli, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Rosa Sirica, Melania Murolo, Emery Di Cicco, Daniela Terracciano, Anna Pannaccione, Monica Dentice   +12 more
wiley   +1 more source

Pressure‐Dependent Aromatic Ring Flips Reveal Variable Transition‐State Volume and Compressibility Among Structural Regions of BPTI

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Pressure‐dependent NMR studies of ring flip dynamics reveal an inverse relationship between the activation energy and the activation volume, as well as the isothermal compressibility of the transition state. The results show how side‐chain packing density in the ground and transition states might affect protein dynamics.
Matthias Dreydoppel, Mikael Akke, Ulrich Weininger   +2 more
wiley   +1 more source

Analyses of coronary graft patency after aprotinin use: Results from the international multicenter aprotinin graft patency experience (IMAGE) trial

, 1998
Objective: We examined the effects of aprotinin on graft patency, prevalence of myocardial infarction, and blood loss in patients undergoing primary coronary surgery with cardiopulmonary bypass.
Nili, Moshe, Griepp, R. B., Hantler, Charles B., Schaff, Hartzell, Nadel, Andrea, Pettersson, Gosta, Chaitman, Bernard, Uretzky, G., Pettersson, G., Bidstrup, B., Westaby, S., Alderman, E. L., Levy, Jerrold H., Rich, J. B., Rich, Jeffrey B., Uretzky, Gideon, Hantler, C. B., Nadel, A., Vidne, B., Thiis, Jens J., Thiis, J. J., Alderman, Edwin L., Vidne, Bernardo, Chaitman, B., Nili, M., Schaff, H., Levy, J. H.   +26 more
core   +1 more source

The use of fibrinolysis inhibitors in cardiac surgery with cardiopulmonary bypass (literature review)

Вестник анестезиологии и реаниматологии
In cardiac surgery with cardiopulmonary bypass (CPB) is a common complication. The incidence of this complication in cardiac surgery patients is estimated at about 10%.
V. Yu. Medvedeva, K. N. Khrapov, A. A. Khryapa, K. Yu. Kankova   +3 more
doaj   +1 more source

Divergent Inhibitor Susceptibility among Airway Lumen-Accessible Tryptic Proteases.

PLoS ONE, 2015
Tryptic serine proteases of bronchial epithelium regulate ion flux, barrier integrity, and allergic inflammation. Inhibition of some of these proteases is a strategy to improve mucociliary function in cystic fibrosis and asthmatic inflammation.
Shilpa Nimishakavi, Wilfred W Raymond, Dieter C Gruenert, George H Caughey   +3 more
doaj   +1 more source

Radiolabeled Angiopep‐2 Peptide Vector as a Preclinical Platform for Blood–Brain Barrier Targeting: Synthesis, Radiolabeling, and Preliminary In Vivo Biodistribution in Mice

Journal of Peptide Science, Volume 32, Issue 7, July 2026.
The developed DOTA‐Angiopep‐2 conjugate was well tolerated in glioma cells and enabled high‐yield radiolabeling with 177Lu and 161Tb. The 161Tb conjugate showed brain delivery with predominantly renal clearance, supporting a stable radiotheranostic platform for BBB‐targeted glioma therapy and SPECT imaging.
Evgenia Fotou, Adamantia Apostolopoulou, Christina‐Georgia Bika, Maria Giannakopoulou, Danai‐Efraimia Bajwa, Vassilios Moussis, Vassilios Tsikaris, Ioannis P. Gerothanassis, George A. Alexiou, Penelope Bouziotis, Andreas G. Tzakos   +10 more
wiley   +1 more source