Results 91 to 100 of about 75,167 (214)

Aprotinina não influencia troponina I, NTproBNP e função renal em crianças operadas com circulação extracorpórea High-dose aprotinin does not affect troponin I, N-Terminal pro-B-type natriuretic peptid and renal function in children submitted to surgical correction with extracorporeal circulation

Brazilian Journal of Cardiovascular Surgery, 2009
OBJETIVO: Avaliar se o uso de aprotinina em altas doses hemostáticas pode influenciar as funções miocárdicas, renais e metabólicas em crianças operadas com circulação extracorpórea (CEC). MÉTODOS: Estudo prospectivo randomizado em crianças de 30 dias a 4
Cesar Augusto Ferreira, Walter Villela de Andrade Vicente, Paulo Roberto Barbosa Évora, Alfredo José Rodrigues, Jyrson Guilherme Klamt, Ana Paula de Carvalho Panzeri Carlotti, Fábio Carmona, Paulo Henrique Manso   +7 more
doaj   +1 more source

Short‐Term Unacylated Ghrelin Administration Improves Pyruvate Tolerance Without Chronically Altering Skeletal Muscle, Liver, or Adipose Tissue Insulin Response in Healthy Rats

The FASEB Journal, Volume 40, Issue 21, 15 November 2026.
Unacylated ghrelin (unAG) has been previously shown to acutely increase fatty acid oxidation (FAO) in skeletal muscle. 5 days of unAG administration to healthy male rats improved pyruvate tolerance, however this was not associated with changes in hepatic glucose‐production associated proteins.
Nicole M. Notaro, Sofia F. Prizio, Brielle R. Caruso, David J. Dyck   +3 more
wiley   +1 more source

Inhibition of trypsin-like enzymes on cells with rhodamine-aprotinin

, 1989
Aprotinin, a polypeptide inhibitor of trypsin-like enzymes, has been labelled with rhodamine. Rhodamine-aprotinin inhibits trypsin in free solution in an identical manner to aprotinin.
Freemont, A. J.; id_orcid, Weidauer, H., Griffin, M. M., Maier, H., Steven, F. S., Williams, L. A.   +5 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, Volume 20, Issue 11, Page 2918-2935, November 2026.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, Volume 20, Issue 11, Page 2674-2698, November 2026.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Aprotinin in cardiac surgery: a different point of view

, 2008
Aprotinin is widely used in cardiac surgery to reduce postoperative bleeding and the need for blood transfusion. Controversy exists regarding the influence of aprotinin on renal function and its effect on the incidence of perioperative myocardial ...
Carrel, Thierry P, Thierry P. Carrel, Stalder, Mario, Lars Englberger, Mario Stalder, Erich Gygax, Englberger, Lars, Gygax, Erich, Jent, Philipp, Immer, Franz F, Philipp Jent, Hendrik T. Tevaearai, Franz F. Immer, Tevaearai, Hendrik T, Tevaearai, Hendrik, Englberger L, Stalder M, Tevaearai HT, Immer FF, Carrel, Thierry, Jent P, Immer, Franz Ferdinand, Carrel TP, Gygax E   +23 more
core   +1 more source

LOW-DOSE APROTININ IN INTERNAL MAMMARY ARTERY BYPASS OPERATIONS CONTRIBUTES TO IMPORTANT BLOOD SAVING

, 1992
The effect on postoperative blood loss and blood use of blood-saving treatment with or without 280 mg of low-dose aprotinin (2 million kallikrein inactivator units) was studied in 200 consecutive patients undergoing either unilateral or bilateral ...
EVERTS, PAM, BREDEE, JJ, SCHONBERGER, JPAM, WILDEVUUR, CRM, BAVINCK, JH, BERREKLOUW, E, ERCAN, H   +6 more
core   +2 more sources

MKP‐2 Genetic Depletion Modulates Adipose Lipid Composition, Cellular Senescence, and Aging in Mice

Aging Cell, Volume 25, Issue 11, November 2026.
Excess white adipose tissue (WAT) accumulation promotes aging by increasing the risk of insulin resistance and chronic diseases and reduced lifespan. MKP‐2 deficiency protects against premature senescence in cells and WAT and is associated with adipose lipid remodeling, improved metabolic health, and longer lifespan.
Morgan Welch, Nabin Ghimire, Shauri Smith, Cassandra Secunda, Alexis Fink, Alissar Sleiman, Laura Chambliss, Christopher Pinckard, Chloe Reyes, Priya Katta, Anna Ai, Benjamin R. Harrison, Ahmed Lawan   +12 more
wiley   +1 more source

Dysregulated TIE‐2 expression is associated with blood‐brain barrier leakiness and Alzheimer's disease‐related neuropathology

Brain Pathology, Volume 36, Issue 6, November 2026.
Ince et al., have analysed TIE‐1 and ‐2 expression in human brain tissue, including microvessel‐enriched fractions (MVF) and covering a spectrum of AD‐associated pathology, and in CSF from independent cohorts spanning a clinical spectrum from normal cognition to AD.
Selvi Ince, Carol Van Hulle, Gwendlyn Kollmorgen, Clara Quijano‐Rubio, Carey Gleason, Barbara B. Bendlin, Ozioma Okonkwo, Sanjay Asthana, Kaj Blennow, Henrik Zetterberg, Sterling C. Johnson, Seth Love, J. Scott Miners   +12 more
wiley   +1 more source

Aprotinin and nafamostat mesilate in liver surgery:Effect on blood loss

, 2007
The origin of blood loss during liver surgery is multifactorial. Surgical skill, technique, anesthesiological care, but also hyperfibrinolysis have been shown to play a role in the origin of bleeding during partial hepatectomy and liver transplantation ...
de Boer, Marieke T., de Boer, Marieke T.; id_orcid, Pereboom, Ilona T. A., Molenaar, I. Quintus, Porte, Robert J.   +4 more
core   +1 more source