Journal of Integrative Plant Biology, EarlyView.Clade A protein phosphatases of type 2C PP2Cs dephosphorylate B3 RAF kinases at a conserved serine residue critical for ATP binding, thereby maintaining their basal activity. Under stress, RAFs rapidly autophosphorylate this residue for autoinhibition.
Chen Zhu +8 more
wiley +1 more source
Treatment of Ligament Constructs with Exercise-conditioned Serum: A Translational Tissue Engineering Model. [PDF]
, 2017 In vitro experiments are essential to understand biological mechanisms; however, the gap between monolayer tissue culture and human physiology is large, and translation of findings is often poor.
Baar, Keith +2 more
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Journal of Anatomy, EarlyView.Anatomical morphometrics have been used to design and manufacture models of the flexor digitorum profundus tendon to bone insertion in vitro. This innovative approach can be used to design models of other enthesis regions with anatomical and clinical applicability.
Jeremy W. Mortimer +2 more
wiley +1 more source
Stem Cell Research & Therapy, 2018 Background Co-cultures of endothelial cells with mesenchymal stem cells currently represent one of the most promising approaches in providing oxygen and nutrient supply for microvascular tissue engineering.
Severin Mühleder +9 more
doaj +1 more source
Inhibitory effects of aprotinin on kallikrein and kininases in dog's blood [PDF]
, 1971 Stefan M Pojda, John R. Vane
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Effect of human myoblasts on tenogenic progression in 2D and 3D culture models
Journal of Anatomy, EarlyView.We investigated whether factors released from muscle derived myogenic cells enhance tenogenic progressions of human tendon derived cells using two‐dimensional (2D) culture model and a three‐dimensional (3D)‐engineered tendon construct culture model.
Yoshifumi Tsuchiya +3 more
wiley +1 more source
Efficacy and safety of antifibrinolytic agents in spinal surgery: a network meta-analysis
Chinese Medical Journal, 2019 . Background:. Significant blood loss is still one of the most frequent complications in spinal surgery, which often necessitates blood transfusion. Massive perioperative blood loss and blood transfusion can create additional risks. Aprotinin, tranexamic
Lei Yuan +7 more
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Oxytocin at physiological concentrations evokes adrenocorticotropin (ACTH) release from corticotrophs by increasing intracellular free calcium mobilized mainly from intracellular stores. Oxytocin displays synergistic or additive effects on ACTH-releasing factor or arginine vasopressin-induced ACTH secretion, respectively [PDF]
, 1992 The potency of oxytocin (OT) in evoking ACTH secretion by isolated, superfused rat adenohypophyseal corticotrophs and its enhancement by CRF and arginine vasopressin (AVP) were analyzed.
Dayanithi, G. +3 more
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Tissue Perfusion and Biomarkers Assessment Following Root Coverage Procedures
Journal of Periodontal Research, EarlyView.Gingival recessions treated with a collagen matrix loaded with rhPDGF showed significantly greater early tissue perfusion compared to sites treated without the growth factor. Early tissue perfusion outcomes were correlated to the amount of root coverage and gingival thickness gain at 6 months.
Lorenzo Tavelli +5 more
wiley +1 more source
Homeostatic Influence of Fig4 Outside of the Fab1‐Vac14‐Fig4 Complex in Saccharomyces cerevisiae
Molecular Microbiology, EarlyView.Disease‐related Fig4 mutants displaying impaired association with the Fab1‐Vac14‐Fig4 complex confer rapamycin tolerance in Saccharomyces cerevisiae independent of Vac14 and Fig4 catalytic function. Fig4 may thus modulate homeostasis through uncharacterized molecular interactions that lead to altered function when not bound to Vac14. ABSTRACT The lipid
Hannah E. Reeves +13 more
wiley +1 more source