Results 111 to 120 of about 103,741 (231)

4‐(5‐Chloro‐3‐(3,4,5‐trimethoxybenzoyl)‐1H‐indol‐1‐yl)benzenesulfonamide: A Novel Polypharmacology Agent to Target Carbonic Anhydrase IX and XII With Improved Selectivity, Wnt/β‐Catenin Signaling Pathway, and P‐Glycoprotein

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
Polypharmacology is expected to produce higher therapeutic efficacy and lower cytotoxic and side effects. Compound 15 exhibited strong inhibition of the human carbonic anhydrase isoforms IX and XII and selectivity toward the adverse isoforms I and II.
Michela Puxeddu, Rosa Bordone, Claudia Colla, Gabriele Rotili, Antonio Coluccia, Pietro Sciò, Petra Cuřínová, Alessio Nocentini, Claudiu T. Supuran, Serena Filiberti, Marta Turati, Roberto Ronca, Joanna Kopecka, Chiara Riganti, Lucia Jimenez, Wolfgang Link, Chiara Bigogno, Giulio Dondio, Martina Barba, Gianluca Canettieri, Romano Silvestri, Giuseppe La Regina   +21 more
wiley   +1 more source

Pilotstudie zur intraoperativen Aprotinin-Applikation bei Patienten mit Rektumtumoren und ihre Auswirkung auf Transfusionsbedarf und Blutverlust [PDF]

, 2002
Im Rahmen dieser Arbeit wurde eine randomisierte, plazebokontrollierte Doppelblindstudie durchgeführt, in der Patienten mit Rektumkarzinom intraoperativ den Serinprotinasen-Inhibitor Aprotinin erhielten. Hauptziel dieser Studie war es, durch die Gabe von
Heckl, Ute
core  

Biochemistry and applications of Aprotimin, the kallikrein inhibitor from bovine organs. [PDF]

, 1985
Fritz, Hans, Wunderer, G.
core   +1 more source

Fibrin gel as a three dimensional matrix in cardiovascular tissue engineering [PDF]

, 2017
Objective: In tissue engineering, three-dimensional biodegradable scaffolds are generally used as a basic structure for cell anchorage, cell proliferation and cell differentiation.
Benedikt, Peter, Hoerstrup, Simon P., Hubbell, Jeffrey A., Jockenhoevel, Stefan, Sakyama, Shelly, Turina, Marko, Ye, Qing, Zünd, Gregor   +7 more
core  

Comparison of three dose regimens of aprotinin in infants undergoing the arterial switch operation

Annals of Cardiac Anaesthesia, 2010
To determine the most effective dose regimen of aprotinin for infants undergoing arterial switch operation for transposition of the great arteries in reducing blood loss and postoperative packed red blood cell (PRBC) requirements.
Verma Yashwant, Chauhan Sandeep, Bisoi Akshay, Gharde Parag, Kiran Usha, Das Sambhu   +5 more
doaj  

Investigation on the mechanisms of action of aprotinin in cardiac surgery [PDF]

, 1991
Baranky, A., Dietrich, W., Friedel, N., Hetzer, P., Jochum, Marianne, Richter, J. A., Royston, D., Spannagl, Michael, Wendt, P.   +8 more
core   +1 more source

Proteinaceous receptors for the import of mitochondrial precursor proteins [PDF]

, 1984
Mild trypsin treatment of isolated Neurospora mitochondria strongly inhibits their ability to bind and import the precursors of several mitochondrial proteins.
Neupert, Walter, Schleyer, Manfred, Zwizinski, Craig   +2 more
core  

Kallikrein inhibitors [PDF]

, 1979
Fink, Edwin, Fritz, Hans, Truscheit, Ernst   +2 more
core   +1 more source

Solving the Structure of eIF2 Bound to eIF2B Using Cryogenic Electron Microscopy [PDF]

, 2019
Translation begins when initiation factor-2 (eIF2) delivers methionyl initiator tRNA (Met-tRNAi) to the ribosome. The exchange of GDP bound to eIF2 for GTP is a prerequisite to binding Met-tRNAi and is mediated by a second initiation factor, eIF2B ...
Kenner, Lillian
core  

Role of leukocytes in hemostasis during orthotopic liver transplantation [PDF]

, 1993
Bechstein, W. O., Himmelreich, G., Huhn, D., Jochum, Marianne, Machleidt, W., Muser, M., Neuhaus, P., Riess, H., Roissaint, R.   +8 more
core   +1 more source