Results 111 to 120 of about 44,465 (273)

The role of fibrinolysis inhibition in engineered vascular networks derived from endothelial cells and adipose-derived stem cells

Stem Cell Research & Therapy, 2018
Background Co-cultures of endothelial cells with mesenchymal stem cells currently represent one of the most promising approaches in providing oxygen and nutrient supply for microvascular tissue engineering.
Severin Mühleder, Karoline Pill, Mira Schaupper, Krystyna Labuda, Eleni Priglinger, Pablo Hofbauer, Verena Charwat, Uwe Marx, Heinz Redl, Wolfgang Holnthoner   +9 more
doaj   +1 more source

Inhibitory effects of aprotinin on kallikrein and kininases in dog's blood [PDF]

, 1971
Stefan M Pojda, John R. Vane
openalex   +1 more source

High‐throughput screen identifies MAS9 as a novel inhibitor of the C‐type lectin receptor‐2 (CLEC‐2)–podoplanin interaction

British Journal of Pharmacology, Volume 182, Issue 16, Page 3838-3851, August 2025.
Abstract Background and Purpose The C‐type lectin‐like receptor‐2 (CLEC‐2) is a platelet receptor for the endogenous ligand podoplanin. This interaction contributes to several (patho)physiological processes, such as lymphangiogenesis, preservation of blood and lymphatic vessel integrity organ development, and tumour metastasis.
Marcin A. Sowa, Yan Wu, Jan van Groningen, Ying Di, Helma van den Hurk, Johannes A. Eble, Jonathan M. Gibbins, Ángel García, Alice Y. Pollitt   +8 more
wiley   +1 more source

ER/K linked GPCR-G protein fusions systematically modulate second messenger response in cells. [PDF]

, 2017
FRET and BRET approaches are well established for detecting ligand induced GPCR-G protein interactions in cells. Currently, FRET/BRET assays rely on co-expression of GPCR and G protein, and hence depend on the stoichiometry and expression levels of the ...
Dysthe, Matthew, Malik, Rabia U, Ritt, Michael, Sivaramakrishnan, Sivaraj, Sunahara, Roger K   +4 more
core   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, Volume 15, Issue 7, Page 1054-1067, July 2025.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source

Inhibition of Intrinsic Thrombin Generation

Drug Target Insights, 2006
Background: The contact phase of coagulation is of physiologic/pathophysiologic importance, whenever unphysiologic polynegative substances such as cell fragments (microparticles) get in contact with blood.
Thomas W. Stief
doaj  

Efficacy and safety of antifibrinolytic agents in spinal surgery: a network meta-analysis

Chinese Medical Journal, 2019
. Background:. Significant blood loss is still one of the most frequent complications in spinal surgery, which often necessitates blood transfusion. Massive perioperative blood loss and blood transfusion can create additional risks. Aprotinin, tranexamic
Lei Yuan, Yan Zeng, Zhong-Qiang Chen, Xin-Ling Zhang, Shuo Mai, Pan Song, Li-Yuan Tao, Qiang Shi   +7 more
doaj   +1 more source

Descending aortic calcification increases renal dysfunction and in-hospital mortality in cardiac surgery patients with intraaortic balloon pump counterpulsation placed perioperatively : a case control study [PDF]

, 2012
Introduction: Acute kidney injury (AKI) after cardiac surgery increases length of hospital stay and in-hospital mortality. A significant number of patients undergoing cardiac surgical procedures require perioperative intra-aortic balloon pump (IABP ...
Bingold, Tobias Michael, Eltzschig, Holger K., Lawlor, Garrett, Mitani, Aya, Nowak-Machen, Martina, Rawn, James D., Rosenberger, Peter, Shekar, Prem S., Shernan, Stanton K., Tuli, Sagun   +9 more
core   +2 more sources

Trypstatin as a Novel TMPRSS2 Inhibitor with Broad‐Spectrum Efficacy against Corona and Influenza Viruses

Advanced Science, Volume 12, Issue 25, July 3, 2025.
Trypstatin, a 61‐amino acid Kunitz‐type protease inhibitor derived from human Bikunin, potently inhibits TMPRSS2 and related proteases. It blocks spike‐ and hemagglutinin‐mediated entry of multiple respiratory viruses in vitro reduces SARS‐CoV‐2 replication in human airway cultures, and lowers viral load and symptoms in infected hamsters, demonstrating
Jan Lawrenz, Lukas Wettstein, Armando Rodríguez Alfonso, Rayhane Nchioua, Pascal von Maltitz, Dan Pascal Jean Albers, Fabian Zech, Julie Vandeput, Lieve Naesens, Giorgio Fois, Veronika Neubauer, Nico Preising, Emilia Schmierer, Yasser Almeida‐Hernandez, Moritz Petersen, Ludger Ständker, Sebastian Wiese, Peter Braubach, Manfred Frick, Eberhard Barth, Daniel Sauter, Frank Kirchhoff, Elsa Sanchez‐Garcia, Annelies Stevaert, Jan Münch   +24 more
wiley   +1 more source

Chrysoeriol Chemosensitized Renal Cell Carcinoma (RCC) Cell Lines to Trigger TRAIL Induced Apoptosis In Vitro by Up‐Regulating Pro‐Apoptotic and Down‐Regulating Anti‐Apoptotic Genetic Factors

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
Recently, a synergistic approach has emerged in clinical settings to sensitize cancer cells towards TRAIL treatment by combining it with some natural antioxidants and anti‐inflammatory compounds for providing chemo‐sensitizing effects. Hence, this study has used the chemo‐sensitizing effect of chrysoeriol for the very first time to sensitize renal ...
Zahra Batool, Qihang Wu, Mohammad Amjad Kamal, Guobin Weng, Bairong Shen   +4 more
wiley   +1 more source