Results 51 to 60 of about 44,465 (273)

Aprotinin in high-risk isolated coronary artery bypass graft patients: a 3-year propensity matched study

Journal of Cardiothoracic Surgery
Background Aprotinin, a serine protease inhibitor, has been used variably in cardiac surgery amidst ongoing debates about its safety following several previous studies.
Rishab Makam, Ayush Balaji, Marwan Al Munaer, Shantanu Bajaj, Nabil Hussein, Mahmoud Loubani   +5 more
doaj   +1 more source

Uso da aprotinina na operação da aorta torácica associada à hipotermia profunda e parada circulatória: metanálise Use of aprotinin in thoracic aortic operations associated with deep hypothermic circulatory arrest: a meta-analysis

Brazilian Journal of Cardiovascular Surgery, 2006
OBJETIVO: Avaliar as complicações decorrentes do uso da aprotinina em pacientes submetidos à cirurgia de aneurisma ou dissecção da aorta torácica, que utilizaram hipotermia profunda e parada circulatória.
Rafael Fagionato Locali, Enio Buffolo, José Honório Palma   +2 more
doaj   +1 more source

Biologically‐Inspired Melt Electrowriting for the Generation of Highly Biomimetic Functional Myocardium

Advanced Functional Materials, EarlyView.
In this work, melt electrowriting is used to fabricate a 3D printed scaffold design that generates engineered cardiac tissues with in‐plane contraction, mimicking natural myocardium. It is shown that these tissues display advanced maturation and functionality.
Olalla Iglesias‐García, María Flandes‐Iparraguirre, Pilar Montero‐Calle, Ricardo M. Rosales, Asier Ullate‐Agote, Andrea Sánchez‐Bueno, Eduardo Larequi, Ilazki Anaut‐Lusar, Nicolás Laita, Aida Oliván‐Viguera, Elena Iglesias, Gloria Abizanda, Patxi San Martín‐Úriz, Paula Aguirre‐Ruiz, Xabier L. Aranguren, Manuel García de Yébenes, Juan José Gavira, Miguel Ángel Martínez, Estefanía Peña, Manuel Doblaré, Elena M. de‐Juan‐Pardo, Esther Pueyo, Felipe Prosper, Manuel M. Mazo Vega   +23 more
wiley   +1 more source

Replacement of aprotinin by ε-aminocaproic acid in infants undergoing cardiac surgery: consequences for blood loss and outcome.

British Journal of Anaesthesia, 2013
BACKGROUND Once aprotinin was no longer available for clinical use, ε-aminocaproic acid (EACA) and tranexamic acid became the only two options for antifibrinolytic therapy.
K. Martin, R. Gertler, M. Macguill, N. Mayr, Alexander Hapfelmeier, J. Hörer, M. Vogt, P. Tassani, G. Wiesner   +8 more
semanticscholar   +1 more source

Optimizing Angiopep‐2 Density on Polymeric Nanoparticles for Enhanced Blood–Brain Barrier Penetration and Glioblastoma Targeting: Insights From In Vitro and In Vivo Experiments

Advanced Functional Materials, EarlyView.
The Angiopep‐2 peptide density on polymeric nanoparticles significantly impacts blood–brain barrier (BBB) penetration. This study explores this nuanced relationship using various in vitro models and in vivo assays, revealing that dynamic models better predict BBB penetration.
Weisen Zhang, Ahmed Refaat, Haoqin Li, Douer Zhu, Ziqiu Tong, Joseph Anthony Nicolazzo, Bo Peng, Hua Bai, Lars Esser, Nicolas Hans Voelcker   +9 more
wiley   +1 more source

Aprotinin and major orthopedic surgery [PDF]

Transfusion Alternatives in Transfusion Medicine, 2004
SUMMARYAprotinin is a potent pharmacological agent which reduces bleeding and limits blood transfusion in current surgical practice. Many studies have been conducted in orthopedic surgery. Several trials have been performed in total hip replacement and total knee replacement patients, and aprotinin only moderately decreased blood loss requirements in ...
openaire   +4 more sources

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

Different aprotinin applications influencing hemostatic chances in orthotopic liver transplantation [PDF]

, 1992
The effect of different aprotinin applications on hemmtatic changes and blood product requirements in orthotopic liver transplantation was investigated in a prospective, open, and randomized study.
Bechstein, W. O., Himmelreich, G., Jochum, Marianne, Muser, M., Neuhaus, P., Riess, H., Slama, K.-J.   +6 more
core  

Flow‐Induced Vascular Remodeling on‐Chip: Implications for Anti‐VEGF Therapy

Advanced Functional Materials, EarlyView.
Flow‐induced vascular remodeling plays a critical role in network stabilization and function. Using a vasculature‐on‐chip system, this study reveals how physiological VEGF levels and flow affect vascular remodeling and provides insights into tumor vessel normalization.
Fatemeh Mirzapour‐Shafiyi, Elias Huber, Leonie Karr, Johnny Tong, Andreas Richard Bausch, Friedrich Christian Simmel, Karen Alim   +6 more
wiley   +1 more source

Pathogenetic treatment of influenza patients with aerosolized form of aprotinin, a protease inhibitor

Биопрепараты: Профилактика, диагностика, лечение, 2018
Therapeutic and antiviral efficacies of inhalations of aerosolized aprotinin, a protease inhibitor, which blocks a stage of influenza virus proteolytic activation, were studied.
O. P. Zhirnov, N. O. Bokova, E. I. Isaeva, I. V. Vorobieva, N. A. Malyshev   +4 more
doaj