Results 61 to 70 of about 74,076 (196)

Aprotinin revisited

, 2012
In 2008, we saw the withdrawal of aprotinin from the US markets after preliminary results from a large, randomized clinical trial in Canada. This drug, a potent antifibrinolytic, was used primarily in complex and/or redo cardiac surgery as an adjunct to ...
Spiess, Bruce D., DeAnda, Abe
core   +1 more source

Aprotinin and Hemostasis Monitoring Concerns During Cardiac Surgery

, 2023
Aprotinin (Trasylol) is a serine protease inhibitor, isolated from bovine lung that initially was marketed for the treatment of pancreatitis. In the mid 1980s, reports of its ability to decrease hemorrhaging after cardiopulmonary bypass surgery ...
Gregory W. Fink, Bruce Searles, Michael F. Swartz   +2 more
core   +1 more source

Extracellular serine-proteinases isolated from Streptomyces alboniger: Partial characterization and effect of aprotinin on cellular structure

Memorias do Instituto Oswaldo Cruz, 1999
Streptomyces alboniger ATCC 12461 grown in brain heart infusion (BHI) medium produced two extracellular serine-proteinases, denoted SP I and SP II, which were purified by ammonium sulfate precipitation and aprotinin-agarose affinity chromatography.
Lopes Andréa, Coelho Rosalie RR, Meirelles Maria Nazareth L, Branquinha Marta Helena, Vermelho Alane Beatriz   +4 more
doaj  

Aerobic Exercise Training Increases Circulating sRAGE in Adults With Type 2 Diabetes: Associations With Sheddase Regulation

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Objective Soluble receptor for advanced glycation end‐products (sRAGE) and soluble Toll‐like receptor 4 (sTLR4) are circulating pattern recognition receptor isoforms implicated in inflammatory regulation in type 2 diabetes mellitus (T2DM). This study examined the effects of supervised aerobic exercise training (AET) on circulating sRAGE, sTLR4,
Ryan K. Perkins, Corey E. Mazo, James Shadiow, Pallavi Varshney, Edwin R. Miranda, Victoria R. Miranda, Maggie Eisenberg, Jane E. Nakamura, Elif A. Oral, Jacob M. Haus   +9 more
wiley   +1 more source

Low dose aprotinin increases mortality and morbidity in coronary artery bypass surgery

Journal of Research in Medical Sciences, 2012
Background: The low dose aprotinin consistently reduces blood and transfusion requirement in adults during cardiac surgical procedures but its effectiveness in some ethnical groups were debated and controversy about its effect on mor-tality and morbidity
Feridoun Sabzi, Gholam Reza Moradi, Heidar Dadkhah, Alireza Poormotaabed, Samsam Dabiri   +4 more
doaj  

CHOICE OF THE TECHNIQUE FOR BLOOD LOSS REDUCTION IN THE RECONSTRUCTIVE ORAL SURGERY

Вестник анестезиологии и реаниматологии, 2018
Goal of the study: to define the most optimal technique for blood loss reduction during reconstructive surgeries in maxillofacilal area. Materials and methods.
A. Yu. Zaitsev, K. V. Dubrovin, V. A. Svetlov   +2 more
doaj   +1 more source

Injured tissues favor cancer cell implantation via fibrin deposits on scar zones

Neoplasia: An International Journal for Oncology Research, 2020
Aim: Evaluation of fibrin role on cancer cells implantation in injured tissues and studying the molecular mechanism of cancer cell interaction with the peritoneal damage.
Iman Al dybiat, Shahsoltan Mirshahi, Meriem Belalou, Djedjiga Abdelhamid, Shahid Shah, Matti Ullah, Jeannette Soria, Marc Pocard, Massoud Mirshahi   +8 more
doaj   +1 more source

ALOX15 mediates thrombin‐induced myristoylation, trafficking, and interaction of protease‐activated receptors, leading to platelet activation and hemostasis

The FEBS Journal, EarlyView.
The role of PARs in platelet function is fairly known; however, the underlying mechanisms are not fully understood. We report that thrombin myristoylates PAR4 in mouse platelets and PAR1 and PAR4 in human platelets, facilitating their membrane transport and interaction, leading to PAR3/4 heterodimers in mice and PAR1/4 heterodimers in humans.
Suresh Govatati, Chandra Sekhar Yadavalli, Md Monirul Hoque, Swapna Thota, Gadiparthi N. Rao   +4 more
wiley   +1 more source

Protective effects of the antioxidant Ginkgo biloba extract and the protease inhibitor aprotinin against Leiurus quinquestriatus venom-induced tissue damage in rats

Journal of Venomous Animals and Toxins including Tropical Diseases, 2006
Oxidative stress and proteases have been implicated in several diseases and extensive evidence indicates that antioxidants and protease inhibitors help prevent organ functional damage. Leiurus quinquestriatus (LQQ) scorpion venom causes cellular injuries
A. J. Fatani, H. A. Al-Zuhair, H. I. Yaquob, A. A. Abdel-Fattah, M. I. El-Sayed, F. A. El-Sayed   +5 more
doaj   +1 more source

Optimal Hypoxia Mimetic Small Molecules for Enhancing Angiogenic Properties of Stem Cells From Human Exfoliated Deciduous Teeth

International Endodontic Journal, EarlyView.
ABSTRACT Aim Hypoxic preconditioning of cells holds promise for regenerative therapies, yet identifying effective and safe methods for clinical application remains challenging. We aimed to determine optimal hypoxia‐mimetic small molecules (SMs) that stabilize hypoxia‐inducible factor‐1α (HIF‐1α) and their dosages for hypoxic preconditioning in stem ...
Hong Wang, Jiawei Liu, Xintao Yang, Mohamad Koohi‐Moghadam, Shuting Gao, Yuanyuan Han, Dineshi Sewvandi Thalakiriyawa, James Kit Hon Tsoi, Yanqi Yang, Waruna Lakmal Dissanayaka   +9 more
wiley   +1 more source