Results 61 to 70 of about 110,212 (273)
British Journal of Pharmacology, EarlyView.Background and Purpose Human adenovirus (HAdV) causes respiratory or gastrointestinal tract infections depending on the virus subtype. While HAdV infections are generally self‐limiting in immunocompetent people, they can result in significant morbidity and mortality in immunocompromised adults and children.
Mohamed Zamzamy +16 more
wiley +1 more source
Diabetes, Obesity and Metabolism, EarlyView.Abstract Aims Mixed evidence exists on whether metformin adds to or attenuates the insulin‐sensitising effects of exercise. To date, no studies have tested whether metformin differentially impacts exercise training intensity–mediated insulin sensitivity.
Steven K. Malin +7 more
wiley +1 more source
E3 ligase Praja1 mediates ubiquitination and degradation of microtubule‐associated protein tau
The FEBS Journal, EarlyView.E3 ligase Praja1, but not its paralogue Praja2, recognizes and ubiquitinates tau protein for proteasomal degradation. This newly identified function of Praja1‐mediated tau degradation suggests its role in protein quality control, which may provide insights into the pathogenesis of tauopathies.
Shiho Aoki +8 more
wiley +1 more source
Memorias do Instituto Oswaldo Cruz, 1999 Streptomyces alboniger ATCC 12461 grown in brain heart infusion (BHI) medium produced two extracellular serine-proteinases, denoted SP I and SP II, which were purified by ammonium sulfate precipitation and aprotinin-agarose affinity chromatography.
Lopes Andréa +4 more
doaj
The FEBS Journal, EarlyView.NOTCH signalling is indispensable for tissue homeostasis and, consequently, corruption of its normal function promotes numerous diseases, including cancer. However, the development of targeted therapies has been hampered by inefficacy and overt toxicity. Here, we show that NOTCH receptor dimerization is necessary for receptor transactivation, which has
Xinxin Liu +9 more
wiley +1 more source
Injured tissues favor cancer cell implantation via fibrin deposits on scar zones
Neoplasia: An International Journal for Oncology Research, 2020 Aim: Evaluation of fibrin role on cancer cells implantation in injured tissues and studying the molecular mechanism of cancer cell interaction with the peritoneal damage.
Iman Al dybiat +8 more
doaj +1 more source
The FEBS Journal, EarlyView.Moderate overexpression of wild‐type Met in hepatocytes (Alb‐R26Met mouse model) boosts a strong antioxidant response dependent on the glutathione system while impairing TGF‐β signaling in the liver. This leads to improved liver regeneration and protects against DDC‐induced injury, a model for cholestatic disease sharing features with primary ...
Carlos González‐Corralejo +16 more
wiley +1 more source
Low dose aprotinin increases mortality and morbidity in coronary artery bypass surgery
Journal of Research in Medical Sciences, 2012 Background: The low dose aprotinin consistently reduces blood and transfusion requirement in adults during cardiac surgical procedures but its effectiveness in some ethnical groups were debated and controversy about its effect on mor-tality and morbidity
Feridoun Sabzi +4 more
doaj
CHOICE OF THE TECHNIQUE FOR BLOOD LOSS REDUCTION IN THE RECONSTRUCTIVE ORAL SURGERY
Вестник анестезиологии и реаниматологии, 2018 Goal of the study: to define the most optimal technique for blood loss reduction during reconstructive surgeries in maxillofacilal area. Materials and methods.
A. Yu. Zaitsev +2 more
doaj +1 more source