Results 221 to 230 of about 53,726 (303)

<i>In vivo</i> selection of anti-glioblastoma DNA aptamer-drug conjugates in an orthotopic patient-derived xenograft model. [PDF]

NAR Cancer
Doherty CD, Jain S, Ott LL, Bakken KK, Wilbanks BA, Burgenske DM, Pearson KS, Griffith JI, Tian Z, Meridew JA, Yerneni SS, Elmquist WF, Sarkaria JN, Maher Iii LJ.   +13 more
europepmc   +1 more source

Reverse‐Engineered Lipid Nanoparticles Harness Protein Corona Formation for Cytokine Sequestration and Combination Immunomodulatory Therapy

Small, EarlyView.
Bioinspired triglyceride‐ceramide lipid nanoparticles were reverse‐engineered from cytokine‐sequestering plant‐derived nanoparticles to capture pathological inflammatory mediators through protein corona formation. Dexamethasone‐loaded TCNPs combine extracellular cytokine sequestration with intracellular immunomodulation, reducing IL‐6, TNF‐α, and NF‐κΒ
Junsik J. Sung, Gargi Yogesh Digholkar, Ryan M. Pearson   +2 more
wiley   +1 more source

In silico design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutralizing antibodies. [PDF]

Elife
Yang Y, Qiao L, Jiang Y, Wang Z, Zhang D, Buratto D, Huang L, Zhou R.   +7 more
europepmc   +1 more source

Identification and Discrimination of Sulfated and Unsulfated Gut‐Hormone Biomarkers in Human Serum by Nanopore

Small, EarlyView.
This study discriminates between sulfated and unsulfated cholecystokinin‐8 gut‐hormone forms at single‐molecule‐level resolution. Using an aerolysin nanopore embedded in a hybrid lipid‐polymer membrane, the system produces distinct electrical signatures enabling highly sensitive detection, even in 20% human serum.
Luca Iesu, Laurent Bacri, Juan Pelta, Benjamin Cressiot   +3 more
wiley   +1 more source

Mechanism underlying the high regulatory performance of the doxycycline riboswitch G12. [PDF]

Nat Commun
Hoetzel J, Walbrun A, Schäfer M, Wang T, Jørgensen AG, Becker O, Stamatakis K, Gunawan V, Reichardt L, Boettger L, Bruckhoff RW, Kjems J, Wachtveitl J, Rief M, Suess B.   +14 more
europepmc   +1 more source

Hoberman‐Inspired Reconfigurable DNA Origami Ring for Nanoscale Capture

Small, EarlyView.
A Hoberman‐inspired DNA origami ring with coupled scissor‐like motion is designed and assembled. Reversible reconfiguration produces different conformations for organization of gold nanoparticles and capture of DNA nanostructures with varied sizes and geometries. ABSTRACT Dynamic DNA origami systems have enabled programmable nanoscale motion and target‐
Henry Wisniewski, Minu Saji, Moisés Reyes, Qi Yang, Fei Zhang   +4 more
wiley   +1 more source

Upconversion nanoplatform unlocks the theranostic potential of Lu-177 radiotherapy via c-MET axis targeting in head and neck squamous cell carcinoma. [PDF]

Mater Today Bio
Lin KH, Wu CY, Chang YC, Chan MH.
europepmc   +1 more source

Mechanism‐Guided Engineering of Upconversion Nanoparticles for Antibacterial Phototherapy: From Photonic Principles to Translational Nanosystems

Small, EarlyView.
This review provides a systematic overview of the field of antibacterial PhotoDynamic Therapy (aPDT) triggered by upconversion nanoparticles (UCNPs), focusing on the mechanisms and the key factors that define their efficacy for generating bactericidal species upon NIR‐light activation.
Zhe Li, Calum Johnston, Barbara Lonetti, Clément Roux   +3 more
wiley   +1 more source

Targeting Adaptive and Innate Immune Responses with Covalent Aptamers. [PDF]

J Am Chem Soc
Albright S, Parikh A, Cacace M, Rosenblum C, Dorogan M, Lohmueller J, Deiters A.   +6 more
europepmc   +1 more source

Competitive SELEX Strategy for High‐Affinity Aptamer Isolation and Enhanced Biosensing

Small, EarlyView.
A novel competitive SELEX strategy was developed to isolate high‐affinity aptamers by using a lower‐affinity competitor during the selection process. This approach enabled the identification of an aptamer with exceptional binding affinity, significantly improving target detection sensitivity.
Jiuxing Li, Jiaxuan Xiao, Jimmy Gu, Zhen Zhang, Yingfu Li   +4 more
wiley   +1 more source